Tetrofosmin
Tetrofosmin Uses, Dosage, Side Effects, Food Interaction and all others data.
Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.
Refer to Technetium Tc-99m tetrofosmin
Trade Name | Tetrofosmin |
Availability | Prescription only |
Generic | Tetrofosmin |
Tetrofosmin Other Names | Tetrofosmin, Tetrofosmina |
Related Drugs | glucagon, mannitol, Tubersol, arginine, inulin |
Type | |
Formula | C18H40O4P2 |
Weight | Average: 382.462 Monoisotopic: 382.240183764 |
Protein binding | Refer to Technetium Tc-99m tetrofosmin |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tetrofosmin is a diphosphine complexed with technetium 99 used for imaging to determine myocardial ischemia, infarcted myocardium, and assessment of left ventricular function.
Tetrofosmin is indicated to be used as a complex with technetium Tc-99m for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It helps in the delineation of regions of reversible myocardial ischemia in absence of infarcted myocardium.
This complex is also used for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease.
This complex is indicated for the assessment of left ventricular function in patients evaluated for heart disease.
Tetrofosmin is also used to associated treatment for these conditions: Breast Cancer, Hypoperfusion, Myocardial Infarction
How Tetrofosmin works
Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.
Toxicity
The toxicity of tetrofosmin as an individual agent has not been studied.
Food Interaction
- Take with food. Some studies have found that this improves imaging.
Tetrofosmin Drug Interaction
Moderate: metoprololUnknown: lactobacillus acidophilus, ibuprofen, fexofenadine, aspirin, diphenhydramine, loratadine, ubiquinone, copper gluconate, cilgavimab / tixagevimab, omega-3 polyunsaturated fatty acids, nirmatrelvir / ritonavir, bioflavonoids, urea, pyridoxine, ascorbic acid, cholecalciferol, zinc sulfate
Volume of Distribution
This pharmacokinetic property has not been fully studied.
Elimination Route
After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.
Half Life
Refer to Technetium Tc-99m tetrofosmin
Clearance
Refer to Technetium Tc-99m tetrofosmin
Elimination Route
Refer to Technetium Tc-99m tetrofosmin
Innovators Monograph
You find simplified version here Tetrofosmin