Tetrofosmin

Tetrofosmin Uses, Dosage, Side Effects, Food Interaction and all others data.

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.

Refer to Technetium Tc-99m tetrofosmin

Trade Name Tetrofosmin
Availability Prescription only
Generic Tetrofosmin
Tetrofosmin Other Names Tetrofosmin, Tetrofosmina
Related Drugs glucagon, mannitol, Tubersol, arginine, inulin
Type
Formula C18H40O4P2
Weight Average: 382.462
Monoisotopic: 382.240183764
Protein binding

Refer to Technetium Tc-99m tetrofosmin

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tetrofosmin
Tetrofosmin

Uses

Tetrofosmin is a diphosphine complexed with technetium 99 used for imaging to determine myocardial ischemia, infarcted myocardium, and assessment of left ventricular function.

Tetrofosmin is indicated to be used as a complex with technetium Tc-99m for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It helps in the delineation of regions of reversible myocardial ischemia in absence of infarcted myocardium.

This complex is also used for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease.

This complex is indicated for the assessment of left ventricular function in patients evaluated for heart disease.

Tetrofosmin is also used to associated treatment for these conditions: Breast Cancer, Hypoperfusion, Myocardial Infarction

How Tetrofosmin works

Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.

Toxicity

The toxicity of tetrofosmin as an individual agent has not been studied.

Food Interaction

  • Take with food. Some studies have found that this improves imaging.

Volume of Distribution

This pharmacokinetic property has not been fully studied.

Elimination Route

After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.

Half Life

Refer to Technetium Tc-99m tetrofosmin

Clearance

Refer to Technetium Tc-99m tetrofosmin

Elimination Route

Refer to Technetium Tc-99m tetrofosmin

Innovators Monograph

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