Thallium(I) Chloride
Thallium(I) Chloride Uses, Dosage, Side Effects, Food Interaction and all others data.
Thallous chloride (also known as Thallium(I) chloride) is a colourless solid intermediate in the isolation of thallium from its ores. It is created from the treatment of thallium(I) sulfate with hydrochloric acid. This solid crystallizes in the caesium chloride motif. It is used as a diagnostic radiopharmaceutical. It is used for diagnosis of heart and parathyroid problems. The following are among the possible side effects: Blurred vision, chest pain or discomfort, chills, confusion, cough, difficulty with breathing, difficulty with swallowing, and dizziness.
Data not found.
| Trade Name | Thallium(I) Chloride |
| Generic | Thallous Chloride |
| Thallous Chloride Other Names | Thallium chloride, thallium monochloride, Thallium(I) chloride, Thallous Chloride Tl-201 |
| Type | |
| Formula | ClTl |
| Weight | Average: 239.836 Monoisotopic: 239.943264977 |
| Protein binding | Data not found. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Thallium(I) Chloride is a diagnostic radiopharmaceutical for myocardial perfusion testing and tests of parathyroid function.
For use as a diagnostic radiopharmaceutical. It is indicated to help diagnose heart disease (eg, coronary artery disease, heart attack). It is also used for the diagnosis of parathyroid problems.
Thallium(I) Chloride is also used to associated treatment for these conditions: Ischemic Heart Disease, Myocardial Infarction, Myocardial Ischemia
How Thallium(I) Chloride works
Thallium(I) Chloride TI201 without carrier, accumulates in the heart (myocardium) in a similar way to that of potassium. Thallium(I) Chloride Tl 201 images have been found to visualize areas of infarction as “cold” or nonlabeled regions which are confirmed by electrocardiographic and enzyme changes. Regions of transient myocardial ischemia corresponding to areas perfused by coronary arteries with partial stenoses have been visualized when Thallium(I) Chloride Tl 201 was administered in conjunction with an exercise stress test. Anatomic configurations may interfere with visualization of the right coronary artery.
Toxicity
LD50 (mouse): 24 mg/kg. Minimum lethal dose (Human): 8 mg/kg. Thallium inhibits enzymes, but nothing is really known of a biochemical lesion. In fatal cases, there usually is extensive peripheral paralysis and cardiovascular involvement. The immediate cause of death may be peripheral respiratory failure of cardiac arrest.
Food Interaction
No interactions found.Volume of Distribution
3–10 L/kg
Elimination Route
After IV administration, thallous chloride clears rapidly from the blood, with maximum concentration in the myocardium after about 10 min. Only 5-8% of injected activity remained in the blood, following 5 minutes of intravenous administration.
Half Life
91% of the blood radioactivity has a t1/2 of 5 min. 9% has t1/2 of 40 hours.
Clearance
Approximately 4-8% of the injected dose was excreted in the urine in the first 24 hours. The whole body disappearance half-time was 9.8 ± 2.5 days. Kidney concentration was found to be about 3 percent of the injected activity and the testicular content was 0.15 percent. Net thyroid activity was determined to be only 0.2 percent of the injected dose, and the activity disappeared in 24 hours. From anterior and posterior whole-body scans, it was determined that about 45 percent of the injected dose was in the large intestines and contiguous structures (liver, kidneys, abdominal musculature).
Elimination Route
Thallium(I) Chloride Tl 201 is excreted slowly and to an equal extent in both feces and urine.
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