Thermoseal Repair
Thermoseal Repair Uses, Dosage, Side Effects, Food Interaction and all others data.
Thermoseal Repair (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession . This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead . Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world .
As an active ingredient in a toothpaste formulation, strontium chloride and the rest of the toothpaste product that it is incorporated into is designed to come into contact with and topically coat the teeth that are being brushed and is not supposed to be swallowed. The regular use of the toothpaste maintains protection that strontium chloride provides against tooth sensitivity despite the normal everyday wear, tear, and cleaning of teeth.
| Trade Name | Thermoseal Repair |
| Generic | Strontium chloride |
| Strontium chloride Other Names | strontium dichloride |
| Weight | 10% |
| Type | Toothpaste |
| Formula | Cl2Sr |
| Weight | Average: 158.52 Monoisotopic: 157.843318 |
| Protein binding | A protein binding of 30-40% has been documented for strontium chloride . |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Icpa Health Products Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Thermoseal Repair is a medication used to treat bone pain in skeletal metastases.
When employed as an ingredient in toothpaste formulations, strontium chloride is predominantly indicated for treating teeth hypersensitivity .
Thermoseal Repair is also used to associated treatment for these conditions: Bone pain
How Thermoseal Repair works
For dental hypersensitivity, strontium ions in strontium chloride toothpaste formulations appear to relieve pain and sensitivity by blocking fluid flow in dentinal tubules, which are essentially microscopic canals in the dentin . Regular use of such toothpastes maintains the strontium chloride barricading of the tubules despite normal everyday wear, tear, and washing of teeth.
Toxicity
Overdosage with strontium chloride toothpaste formulations has not been reported.
Food Interaction
No interactions found.Volume of Distribution
The distribution of absorbed strontium in the human body is similar to that of calcium, with about 99% of total amount in the body being distributed in the skeleton .
Elimination Route
About 30 percent of ingested strontium is absorbed into the blood through the gut . The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life . Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat . About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year .
Half Life
Readily accessible information about the half-life of strontium calcium used in toothpastes is not available.
Clearance
Despite being the major route of excretion of absorbed strontium, urinary excretion of absorbed strontium is observed to be slow .
Elimination Route
Once strontium is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat .
Innovators Monograph
You find simplified version here Thermoseal Repair
