Thiophosphamide liofilised for injections

Thiophosphamide liofilised for injections Uses, Dosage, Side Effects, Food Interaction and all others data.

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.

The unstable nitrogen-carbon groups alkylate with DNA causing irrepairable DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically.

Trade Name Thiophosphamide liofilised for injections
Availability Prescription only
Generic Thiotepa
Thiotepa Other Names Thiotepa
Related Drugs prednisone, methotrexate, dexamethasone, Arimidex, carboplatin, fluorouracil, doxorubicin, cisplatin, paclitaxel, cyclophosphamide
Type
Formula C6H12N3PS
Weight Average: 189.218
Monoisotopic: 189.048954601
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Russia
Last Updated: September 19, 2023 at 7:00 am
Thiophosphamide liofilised for injections
Thiophosphamide liofilised for injections

Uses

Thiophosphamide liofilised for injections is an alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.

ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.

Thiophosphamide liofilised for injections is also used to associated treatment for these conditions: Adenocarcinoma of the Ovaries, Breast Adenocarcinoma, Papillary transitional cell carcinoma of bladder, Malignant effusion

How Thiophosphamide liofilised for injections works

The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically.

Food Interaction

  • Exercise caution with grapefruit products. Grapefruit inhibits the CYP3A4 metabolism of thiotepa, which may increase its serum concentration.
  • Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism and may reduce serum levels of thiotepa.

Thiophosphamide liofilised for injections Disease Interaction

Major: infections, hepatic dysfunction, myelosuppression, renal dysfunction

Half Life

1.5 to 4.1 hours

Clearance

  • 446 +/- 63 mL/min [female patients (45 to 84 years) with advanced stage ovarian cancer receiving 60 mg and 80 mg thiotepa by intravenous infusion on subsequent courses given at 4-week intervals]

Elimination Route

Urinary excretion of 14C-labeled thiotepa and metabolites in a 34-year old patient with metastatic carcinoma of the cecum who received a dose of 0.3 mg/kg intravenously was 63%.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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