Thioridazine Thiomethyl Sulfoxide

Thioridazine Thiomethyl Sulfoxide Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine antipsychotic with effects similar to chlorpromazine.

Thioridazine Thiomethyl Sulfoxide, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.

Table Of contents

• Thioridazine Thiomethyl Sulfoxide
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Thioridazine Thiomethyl Sulfoxide
Availability	Discontinued
Generic	Mesoridazine
Mesoridazine Other Names	Mesoridazina, Mesoridazine, Mesoridazinum, Thioridazine 2-sulfoxide, Thioridazine thiomethyl sulfoxide
Related Drugs	quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone
Type
Formula	C21H26N2OS2
Weight	Average: 386.574 Monoisotopic: 386.148654844
Protein binding	4%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Thioridazine Thiomethyl Sulfoxide is a phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses.

Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.

How Thioridazine Thiomethyl Sulfoxide works

Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action.

Toxicity

Oral LD₅₀ is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.

Food Interaction

• Take with food. Food reduces irritation.

Thioridazine Thiomethyl Sulfoxide Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.

Patients should be advised to avoid alcohol during phenothiazine therapy.

Thioridazine Thiomethyl Sulfoxide Drug Interaction

Major: clomipramine, clomipramine, bupropion, bupropion, citalopram, citalopramModerate: aripiprazole, aripiprazole, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, zolpidem, zolpidem, zolpidem, zolpidem, chlordiazepoxide, chlordiazepoxideUnknown: disulfiram, disulfiram

Thioridazine Thiomethyl Sulfoxide Disease Interaction

Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia

Elimination Route

Well absorbed from the gastrointestinal tract.

Half Life

24 to 48 hours

Innovators Monograph

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