Thiosulfil Forte

Thiosulfil Forte Uses, Dosage, Side Effects, Food Interaction and all others data.

A sulfathiazole antibacterial agent.

Thiosulfil Forte is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Thiosulfil Forte
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Thiosulfil Forte
Availability	Discontinued
Generic	Sulfamethizole
Sulfamethizole Other Names	Sulfamethizol, Sulfaméthizol, Sulfamethizole, Sulfamethizolum, Sulfamethylthiadiazole, Sulfametizol
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin
Type
Formula	C₉H₁₀N₄O₂S₂
Weight	Average: 270.331 Monoisotopic: 270.024516964
Protein binding	98-99%
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Thiosulfil Forte is a sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections.

For the treatment of urinary tract infection

Thiosulfil Forte is also used to associated treatment for these conditions: Cystitis, Genital tract inflammation, Gonorrhea, Nephritis, Prostatitis, Urinary Tract Infection, Urinary tract inflammation, Vaginal Inflammation

How Thiosulfil Forte works

Thiosulfil Forte is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.