Thiosulfil Forte

Thiosulfil Forte Uses, Dosage, Side Effects, Food Interaction and all others data.

A sulfathiazole antibacterial agent.

Thiosulfil Forte is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name Thiosulfil Forte
Availability Discontinued
Generic Sulfamethizole
Sulfamethizole Other Names Sulfamethizol, Sulfaméthizol, Sulfamethizole, Sulfamethizolum, Sulfamethylthiadiazole, Sulfametizol
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin
Type
Formula C9H10N4O2S2
Weight Average: 270.331
Monoisotopic: 270.024516964
Protein binding

98-99%

Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Thiosulfil Forte
Thiosulfil Forte

Uses

Thiosulfil Forte is a sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections.

For the treatment of urinary tract infection

Thiosulfil Forte is also used to associated treatment for these conditions: Cystitis, Genital tract inflammation, Gonorrhea, Nephritis, Prostatitis, Urinary Tract Infection, Urinary tract inflammation, Vaginal Inflammation

How Thiosulfil Forte works

Thiosulfil Forte is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Food Interaction

  • Take separate from meals. Take Urobiotic at least 1 hour before or 2 hours after eating.

Thiosulfil Forte Disease Interaction

Major: hematologic toxicity

Elimination Route

Rapidly absorbed.

Half Life

3-8 hours

Innovators Monograph

You find simplified version here Thiosulfil Forte

*** Taking medicines without doctor's advice can cause long-term problems.
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