Tiagabine
Tiagabine Uses, Dosage, Side Effects, Food Interaction and all others data.
Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Tiagabine is used primarily as an anticonvulsant for the adjunctive treatment of epilepsy. The precise mechanism by which Tiagabine exerts its antiseizure effect is unknown, although it is believed to be related to its ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Tiagabine binds to recognition sites associated with the GABA uptake carrier. It is thought that, by this action, Tiagabine blocks GABA uptake into presynaptic neurons, permitting more GABA to be available for receptor binding on the surfaces of post-synaptic cells.
| Trade Name | Tiagabine |
| Availability | Prescription only |
| Generic | Tiagabine |
| Tiagabine Other Names | Tiagabina, Tiagabine, Tiagabinum |
| Related Drugs | gabapentin, clonazepam, lamotrigine, diazepam, pregabalin, Lyrica, topiramate, levetiracetam, Keppra, Topamax |
| Weight | 12mg, 16mg, 2mg, 20mg, 4mg, |
| Type | Oral Tablet, Tablet, Film Coated |
| Formula | C20H25NO2S2 |
| Weight | Average: 375.548 Monoisotopic: 375.132670429 |
| Protein binding | 96% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tiagabine is an antiepileptic used to treat partial seizures.
For the treatment of partial seizures
Tiagabine is also used to associated treatment for these conditions: Partial-Onset Seizures
How Tiagabine works
Though the exact mechanism by which Tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Toxicity
mptoms most often accompanying tiagabine overdose, alone or in combination with other drugs, have included: seizures including status epilepticus in patients with and without underlying seizure disorders, nonconvulsive status epilepticus, coma, ataxia, confusion, somnolence, drowsiness, impaired speech, agitation, lethargy, myoclonus, spike wave stupor, tremors, disorientation, vomiting, hostility, and temporary paralysis. Respiratory depression was seen in a number of patients, including children, in the context of seizures.
Food Interaction
- Avoid alcohol. Ingesting alcohol may increase drowsiness and dizziness.
- Take with food.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Tiagabine Drug Interaction
Moderate: aripiprazole, zolpidem, diphenhydramine, duloxetine, pregabalin, pramipexole, gabapentin, fluoxetine, vortioxetine, diazepam, sertralineUnknown: fexofenadine, aspirin, celecoxib, fluticasone nasal, levetiracetam, lamotrigine, cyanocobalamin, cholecalciferol, bupropion
Tiagabine Disease Interaction
Elimination Route
Tiagabine is nearly completely absorbed (>95%).
Half Life
7-9 hours
Clearance
- 109 mL/min [Healthy subjects]
Elimination Route
Approximately 2% of an oral dose of tiagabine is excreted unchanged, with 25% and 63% of the remaining dose excreted into the urine and feces, respectively, primarily as metabolites.
Innovators Monograph
You find simplified version here Tiagabine
