Ticarcilline

Ticarcilline Uses, Dosage, Side Effects, Food Interaction and all others data.

An antibiotic derived from penicillin similar to carbenicillin in action.

Ticarcilline is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcilline is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.

Ticarcilline
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ticarcilline
Availability	Discontinued
Generic	Ticarcillin
Ticarcillin Other Names	Ticarcilina, Ticarcillin, Ticarcilline, Ticarcillinum
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Type
Formula	C₁₅H₁₆N₂O₆S₂
Weight	Average: 384.427 Monoisotopic: 384.044977634
Protein binding	45%
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ticarcilline is a beta lactam antibiotic used to treat a variety of infections in the body.

For the treatment of bacterial infections.

Ticarcilline is also used to associated treatment for these conditions: Infection

How Ticarcilline works

Ticarcilline's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.

Toxicity

As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.

Ticarcilline Hypertension interaction

[Moderate] Parenteral ticarcillin disodium contains approximately 120 to 150 mg (5.2 to 6.5 mEq) of sodium per each gram of ticarcillin activity.

The combination, ticarcillin-clavulanate, contains approximately 109 mg (4.75 mEq) of sodium per gram of total drug.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

In addition, hypokalemia has been reported rarely during therapy with ticarcillin and other extended-spectrum penicillin antibiotics, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance.

Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.