Tiorfan Nourrisson
Tiorfan Nourrisson Uses, Dosage, Side Effects, Food Interaction and all others data.
Tiorfan Nourrisson increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. The enkephalins in turn mediate their effect through δ receptor ( delta opioid receptor) activation that induces a selective increase in Cl absorption by inhibiting adenylate cyclase.
Onset: 30 min (plasma enkephalinase inhibition).
| Trade Name | Tiorfan Nourrisson |
| Generic | Racecadotril |
| Racecadotril Other Names | Racecadotril, Racecadotrilo |
| Type | |
| Formula | C21H23NO4S |
| Weight | Average: 385.48 Monoisotopic: 385.134779399 |
| Groups | Investigational |
| Therapeutic Class | Anti-diarrhoeal |
| Manufacturer | |
| Available Country | France |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tiorfan Nourrisson is used for the symptomatic treatment of acute diarrhea.
Tiorfan Nourrisson is a pure intestinal antisecretory active substance. It decreases the intestinal hypersecretion of water and electrolytes induced by cholera toxin or inflammation and does not have effects on basal secretory activity.
Following oral administration, Tiorfan Nourrisson is rapidly absorbed and then hydrolysed to thiorphan, which is an inhibitor of enkephalinase, a cell membrane peptidase located in various tissues, notably the epithelium of the small intestine. This enzyme contributes both to the hydrolysis of exogenous peptides and to the breakdown of endogenous peptides such as enkephalins. Tiorfan Nourrisson protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing hypersecretion. Tiorfan Nourrisson exerts rapid antidiarrhoeal action, without modifying the duration of intestinal transit.
Tiorfan Nourrisson is also used to associated treatment for these conditions: Acute Diarrhoea, Diarrhoea
Dosage
Tiorfan Nourrisson dosage
Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals.
Children (from 3 months of age): Tiorfan Nourrisson granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily.
- Infants less than 9 kg: one 10 mg sachet 3 times daily.
- Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily.
- Children from 13 kg to 27 kg: one 30mg sachet 3 times daily.
- Children of more than 27 kg: two 30mg sachets 3 times daily.
Side Effects
Headache, erythema multiforme, urticaria, angioedema may be seen.
Precaution
The administration of Tiorfan Nourrisson does not modify the usual rehydration regimens. The presence of bloody stools and fever may indicate the presence of invasive bacteria as a reason for diarrhea or the presence of other severe disease. Tiorfan Nourrisson has not been tested in antibiotic-associated diarrhea and should therefore not be administered under these conditions. Caution should be taken in patients with renal or liver impairment.
Interaction
No drug interactions found. Joint treatment with Tiorfan Nourrisson and Loperamide or Nifuroxazide does not modify the kinetics of Tiorfan Nourrisson.
Pregnancy & Breastfeeding use
Due to a lack of clinical data, Tiorfan Nourrisson should not be administered to pregnant or breastfeeding women.
Contraindication
Hypersensitivity to Tiorfan Nourrisson, or to any of the excipients.
Acute Overdose
No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.
Innovators Monograph
You find simplified version here Tiorfan Nourrisson
Tiorfan Nourrisson contains Racecadotril see full prescribing information from innovator Tiorfan Nourrisson Monograph, Tiorfan Nourrisson MSDS, Tiorfan Nourrisson FDA label
FAQ
When should I take Tiorfan Nourrisson?
Tiorfan Nourrisson should be taken for acute diarrhoea exactly as your doctor tells you to. It is taken three times daily at regular intervals until the diarrhoea stops (but for no longer than seven days in total). You should give the first dose as soon as possible.
How long does Tiorfan Nourrisson take to work?
Tiorfan Nourrisson is administered by the oral route, is well absorbed from the intestinal tract and is rapidly converted to its active metabolite thiorphan. Peak plasma levels are attained in about an hour and half life of the drug is three hours.
Is Tiorfan Nourrisson antibiotic?
Tiorfan Nourrisson has an anti-secretory effect. It reduces the secretion of water and electrolytes from the intestine. This helps to reduce the amount of fluid loss from the body in diarrhoea.
What are the side effects of Tiorfan Nourrisson?
The most common adverse effect is headache, which occurs in 1–2% of patients. Rashes occur in fewer than 1% of patients. Other described skin reactions include itching, urticaria, angioedema, erythema multiforme, and erythema nodosum.
You should stop giving Tiorfan Nourrisson to your child and see your doctor immediately if your child experiences symptoms of angioedema, such as:
- swollen face, tongue or pharynx
- difficulty to swallow
- hives and difficulties to breath
How do you use Tiorfan Nourrisson?
The Tiorfan Nourrisson should be added to food or mixed with water in a glass or baby bottle. Mix well and give immediately to your child. The recommended daily dose depends on your child's weight: 1.5 mg/kg per dose (corresponding to 1 to 2 sachets), three times daily at regular intervals.
Is Tiorfan Nourrisson safe for breastfeeding?
Apple pectin and activated (medical) charcoal may be taken during breastfeeding. Oral tannin or ethacridine also do not harm the breastfed baby. Loperamide may be prescribed temporarily during breastfeeding if dietary measures are insufficient. Tiorfan Nourrisson should not be used as its safety has not yet been established.
Is Tiorfan Nourrisson safe for Pregnancy?
Use of Tiorfan Nourrisson is not recommended in case of pregnancy and breast feeding.
Ask your doctor or pharmacist for advice before taking this medicine.
