Tiotixene

Tiotixene Uses, Dosage, Side Effects, Food Interaction and all others data.

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

Tiotixene is an antipsychotic of the thioxanthene series. Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.

Trade Name Tiotixene
Availability Prescription only
Generic Thiothixene
Thiothixene Other Names cis-thiothixene, Thiothixene, Tiotixene, Tiotixeno, Tiotixenum
Related Drugs quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine
Type
Formula C23H29N3O2S2
Weight Average: 443.625
Monoisotopic: 443.170118567
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tiotixene
Tiotixene

Uses

Tiotixene is an antipsychotic indicated for the management of schizophrenia.

For the management of schizophrenia.

Tiotixene is also used to associated treatment for these conditions: Schizophrenia

How Tiotixene works

Tiotixene acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).

Toxicity

Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.

Food Interaction

  • Avoid alcohol.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Half Life

10-20 hours

Innovators Monograph

You find simplified version here Tiotixene

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0003412
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http://classyfire.wishartlab.com/tax_nodes/C0000199
http://classyfire.wishartlab.com/tax_nodes/C0003864
http://classyfire.wishartlab.com/tax_nodes/C0003358
http://classyfire.wishartlab.com/tax_nodes/C0001585
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0003137
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://www.hmdb.ca/metabolites/HMDB0015560
http://www.genome.jp/dbget-bin/www_bget?drug:D00374
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=941651
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505564
https://www.chemspider.com/Chemical-Structure.819430.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=78576
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10510
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=9571
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201
https://zinc.docking.org/substances/ZINC000030690433
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000318
http://www.pharmgkb.org/drug/PA451669
http://www.rxlist.com/cgi/generic/thiothix.htm
https://www.drugs.com/cdi/thiothixene.html
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/nav1285.shtml
https://en.wikipedia.org/wiki/Thiothixene
*** Taking medicines without doctor's advice can cause long-term problems.
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