Tit
Tit Uses, Dosage, Side Effects, Food Interaction and all others data.
Tit is structurally and pharmacologically related to vitamin A. Current evidence suggests that topical Tit decreases cohesiveness of follicular epithelial cells with decreased microcomedone formation. Additionally, Tit stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones
Tit, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tit also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
| Trade Name | Tit |
| Availability | Prescription only |
| Generic | Tretinoin |
| Tretinoin Other Names | Acide retinoique, all trans Retinoic acid, all trans-Retinoic acid, all-(E)-Retinoic acid, all-trans-Retinoic acid, all-trans-Tretinoin, all-trans-Vitamin A acid, all-trans-Vitamin A1 acid, ATRA, beta-Retinoic acid, Retinoic acid, Retionic acid, trans-Retinoic acid, Tretin M, Tretinoin, Tretinoina, Trétinoïne, Tretinoinum, Vitamin A acid |
| Related Drugs | arsenic trioxide, Trisenox, Vesanoid |
| Type | Cream |
| Formula | C20H28O2 |
| Weight | Average: 300.442 Monoisotopic: 300.208930142 |
| Protein binding | > 95% |
| Groups | Approved, Investigational, Nutraceutical |
| Therapeutic Class | Topical retinoid and related preparations |
| Manufacturer | Satyam Health Care Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
- For the treatment of acne vulgaris in which comedones, papules and pustules predominate.
- For the treatment of hyperpigmentation, roughness and fine wrinkling of photodamaged skin due to chronic sun exposure.
- For the treatment of Acute promyelocytic leukaemia
Tit is also used to associated treatment for these conditions: Acne Vulgaris, Alopecia, Cornification and dystrophic skin disorders, FAB classification M3 Acute promyelocytic leukemia, Skin hyperpigmentation, Solar Lentigines, Facial fine wrinkling, Keratinization disorders of the feet, Keratinization disorders of the hand, Moderate Melasma, Mottled hyperpigmentation, Severe Melasma, Severe, recalcitrant Cystic acne, Tactile roughness of facial skin
How Tit works
Tit binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tit promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tit is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tit is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.
Dosage
Tit dosage
Tit cream: Tit cream should be applied sparingly to the whole affected area once or twice daily. The skin should be thoroughly cleaned and dried before application. Patient should be advised that 6 to 8 weeks of treatment may be required before a therapeutic effect is observed. Moisturisers and cosmetics may be used during treatment with Cosmotrin cream but should not be applied to the skin at the same time. Astringent toiletries should be avoided.
Tit gel: Tit gel should be applied once or twice a day, before retiring, to the skin where lesions appear, using enough to cover the entire affected area lightly. The frequency of application can be adjusted to obtain maximum clinical efficacy with minimal erythema and scaling.
If Tit gel is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Should this occur accidentally or through over-enthusiastic use, application should be discontinued for few days.
Patience is needed in this treatment, since the therapeutic effects will not usually be observed until after 6-8 weeks of treatment. During the early weeks of treatment, an apparent exacerbation of inflammatory lesions may occur. This is due to the action of the medication on deep, previously unseen comedones and papules. Once the acne lesions have responded satisfactorily, it should be possible to maintain the improvement with less frequent applications.
Moisturizers and cosmetics may be used during treatment with Tit gel but should not be applied to the skin at the same time. The skin should be thoroughly washed before application of Tit gel. Astringent toiletries should be avoided.
Capsule: The recommended dose is 45 mg/m2/day administered as two evenly divided doses until complete remission is documented. Therapy should be discontinued 30 days after achievement of complete remission or after 90 days of treatment, whichever occurs first.
If after initiation of treatment of Tit the presence of the translocation is not confirmed by cytogenetics and/or by polymerase chain reaction studies and the patient has not responded to Tit, alternative therapy appropriate for acute myelogenous leukemia should be considered.
Side Effects
True allergic contact dermatitis is rare but a primary irritant dermatitis, manifesting itself as irritation, erythema, peeling and sensation of warmth, is common. Slight stinging is common as a mild reaction in many people but usually settles with continuous use and/or reduction in the frequency of application of the drug.
Interaction
Particular caution should be exercised in using preparations containing peeling agents (i.e. sulfur, resorcinol, benzoyl peroxide or salicylic acid). Use of topical preparations with high concentrations of alcohol, menthol, spices or lime- such as shaving lotions, astringents and perfume- should be avoided, especially during initial therapy.
Food Interaction
- Take with food. Tit absorption may be increased by co-administration with food.
Tit Cholesterol interaction
[Moderate] A reversible elevation of cholesterol and Venous thrombosis and myocardial infarction have occurred in patients at low risk for such complications. Therapy with tretinoin should be administered cautiously in patients with or predisposed to hypercholesterolemia and Clinical monitoring of lipid profile is recommended.
Tit Drug Interaction
Unknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, zolpidem, loratadine, sulfamethoxazole / trimethoprim, ubiquinone, duloxetine, meperidine, venlafaxine, omega-3 polyunsaturated fatty acids, cyclobenzaprine, escitalopram, bifidobacterium infantis / lactobacillus acidophilus, tiotropium, levothyroxine, cyanocobalamin, ascorbic acid, cholecalciferol, lisdexamfetamine
Tit Disease Interaction
Elimination Route
1-31% (topical)
Half Life
0.5-2 hours
Pregnancy & Breastfeeding use
Tit is contraindicated in pregnancy or suspected pregnancy. The drug should be avoided by breast feeding mothers.
Contraindication
Tit is contraindicated in patients who are allergic to this drug. It is contraindicated in pregnancy or suspected pregnancy. It is also contraindicated in personal or familial history of cutaneous epithelioma.
Local irritation: The presence of cutaneous irritative signs (e.g. erythema, peeling, pruritus, sunburn, etc.) should prohibit initiation or recommencement of treatment with Tit until the symptoms resolve. Tit has been reported to cause severe irritation on eczematous skin and should be used with caution in patients with this condition.
Exposure to sunlight: Exposure to sunlight, including ultraviolet sun-lamps, should be avoided or minimised during the use of Tit.
General precaution: Before application of Tit, areas to be treated should be cleansed thoroughly. Abstain from washing the treated area frequently; twice daily is sufficient. Use of mild soap is recommended. Dry the skin without rubbing.
Avoid contact with eyes, eyelids, nostrils, mouth and mucous membranes. If contact in these areas occurs, careful washing with water is recommended.
Storage Condition
Store in a cool and dry place, away from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Tit
Tit contains Tretinoin see full prescribing information from innovator Tit Monograph, Tit MSDS, Tit FDA label
FAQ
What is Tit used for?
Tit used to treat acne and sun-damaged skin. It can't erase deep wrinkles, but it can help improve the appearance of surface wrinkles, fine lines, and darks spots.
How safe is Tit?
Tit is a safe and effective medication. However, some users experience side effects ranging from minor skin irritation that goes away with long-term use to more severe adverse effects.
What are the common side effects of Tit?
Common side effects of Tit are include:
- Burning, itching, stinging, scaling, or redness of the skin.
- chapping or slight peeling of the skin (mild)
- darkening of the skin.
- lightening of normal skin color.
- lightening of treated areas of dark skin.
- redness of skin (mild)
- unusual dryness of skin (mild)
- unusually warm skin (mild)
Is Tit safe during pregnancy?
Because many individuals have used tretinoin during pregnancy and have not had babies with a birth defect, the chance for birth defects is probably low. However, it is generally recommended not to use tretinoin in pregnancy.
Is Tit safe during breastfeeding?
Tit is generally considered compatible with breastfeeding. absorption of Tit via topical sources is reported to be minimal, and breastmilk concentrations would likely be minimal to none.
Can I drink alcohol with Tit?
Topical retinoid drugs do not have interactions with alcoholic beverages.
Can I drive after taking Tit?
You should know that Tit may cause dizziness or severe headache.Do not drive a car or operate machinery until you know how this medication affects you.
What should I not use after tretinoin?
Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as Tit: Any other topical acne product or skin product containing a peeling agent.
When should I not use Tit?
Most of the time, Tit cream is safe even if you have sensitive skin. However, if you experience a severe skin reaction, an uncomfortable or painful skin rash, or a severe breakout that doesn't heal within one month, you should contact your doctor for assistance.
Where should I not use Tit?
Do not apply this medicine to windburned or sunburned skin or on open wounds. Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once.
Does Tit lighten skin?
It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun.
Can I leave Tit on overnight?
Usually Tit is applied at night so that it does not cause a problem with any other topical products that you might use during the day.
Does Tit affect fertility?
Tit must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that tretinoin will cause the baby to be born with birth defects.
Does Tit increase facial hair?
Tit was shown to stimulate some hair regrowth in approximately of the subjects studied.
Can Tit cause liver damage?
Liver damage which may cause yellowing of eyes and skin enlarged liver and spleen.
Does Tit heal scars?
Tit in several forms has been tested successfully as an effective way to treat acne scars.Tit is also sometimes used to prep skin for chemical peel treatments that target scarring.
What happens if I stop using Tit?
If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time.
Will I breakout if I stop using Tit?
Most people can expect to see results within four to six weeks and will continue to see results for as long as they use it. While it's possible for tretinoin to eliminate some dark spots and discolorations, it's also possible for acne to come back once discontinuing Tit.
Can I use Tit forever?
Studies also show that it's safe to use Tit over the long term, with some studies examining the effects of Tit for as long as four years.
What happens if I use too much Tit?
excessive amounts of Tit onto the skin to make acne go away faster will not work. This can make the skin worse by causing extreme dryness, peeling, or redness. It may take up to six weeks of Tit treatment to see results.
Is Tit bad for my skin?
Like all retinoids Tit can thin your skin, making it more prone to sun damage and sunburn.
