Tofe Ci

Tofe Ci Uses, Dosage, Side Effects, Food Interaction and all others data.

Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin.

Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.

Trade Name Tofe Ci
Generic Carbonyl Iron + Folic Acid
Type Capsule
Therapeutic Class Iron & Vitamin Combined preparations
Manufacturer Alkem Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Tofe Ci
Tofe Ci

Uses

Dietary supplements, Iron deficiency, Iron deficiency anemia, Pregnancy, Pregnancy and lactation

Tofe Ci is also used to associated treatment for these conditions: Anaemia folate deficiency, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Latent Iron Deficiency, Neural Tube Defects (NTDs), Vitamin Deficiency, Methotrexate toxicity, Nutritional supplementation

How Tofe Ci works

Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Dosage

Tofe Ci dosage

One capsule daily. In more severe cases, 2 capsules a day may be required or as directed by the physician.

May be taken with or without food.

Side Effects

Iron: Constipation, Diarrhea, Nausea, Epigastric pain, Dark stools, Vomiting Frequency Not Defined Hemosiderosis (during long-term administration of large amounts),Urine discoloration,Dental stain by some formulations,Heartburn

Folic acid: Bronchospasm, Erythema, Malaise, Pruritus, Rash, Slight flushing

Toxicity

IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg

Precaution

Care should be taken in patients who may develop iron overload, such as those with haemochromatosis, haemolytic anemia or red cell aplasia. Iron chelates with tetracycline and absorption may be impaired

Interaction

Carbonyl iron: Antacids may decrease the absorption of carbonyl iron.

Folic acid: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.

Volume of Distribution

Tetrahydrofolic acid derivatives are distributed to all body tissues but are stored primarily in the liver.

Elimination Route

Folic acid is absorbed rapidly from the small intestine, primarily from the proximal portion. Naturally occurring conjugated folates are reduced enzymatically to folic acid in the gastrointestinal tract prior to absorption. Folic acid appears in the plasma approximately 15 to 30 minutes after an oral dose; peak levels are generally reached within 1 hour.

Elimination Route

After a single oral dose of 100 mcg of folic acid in a limited number of normal adults, only a trace amount of the drug appeared in the urine. An oral dose of 5 mg in 1 study and a dose of 40 mcg/kg of body weight in another study resulted in approximately 50% of the dose appearing in the urine. After a single oral dose of 15 mg, up to 90% of the dose was recovered in the urine. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Small amounts of orally administered folic acid have also been recovered in the feces. Folic acid is also excreted in the milk of lactating mothers.

Pregnancy & Breastfeeding use

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Lactation: Excreted in breast milk

Contraindication

Tofe Ci is contraindicated in patients with a known hypersensitivity to any of the ingredients

Storage Condition

Store at 15-30° C.

Innovators Monograph

You find simplified version here Tofe Ci


*** Taking medicines without doctor's advice can cause long-term problems.
Share