Tolrestat

Tolrestat Uses, Dosage, Side Effects, Food Interaction and all others data.

Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. It was sold under the tradename Alredase but was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death.

Trade Name Tolrestat
Generic Tolrestat
Tolrestat Other Names Tolrestat
Type
Formula C16H14F3NO3S
Weight Average: 357.347
Monoisotopic: 357.064648624
Groups Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tolrestat
Tolrestat

Uses

For the pharmacological control of certain diabetic complications.

Toxicity

Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

Innovators Monograph

You find simplified version here Tolrestat

*** Taking medicines without doctor's advice can cause long-term problems.
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