Tonocebrinon

Tonocebrinon Uses, Dosage, Side Effects, Food Interaction and all others data.

A peptide that is a homopolymer of glutamic acid.

In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.

Trade Name Tonocebrinon
Generic Glutamic acid
Glutamic acid Other Names ácido glutámico, Glutamic acid
Type
Formula C5H9NO4
Weight Average: 147.1293
Monoisotopic: 147.053157781
Groups Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country Georgia
Last Updated: September 19, 2023 at 7:00 am
Tonocebrinon
Tonocebrinon

Uses

Tonocebrinon is an amino acid commonly found as a component in total parenteral nutrition.

Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.

Tonocebrinon is also used to associated treatment for these conditions: Amino acid supplementation

How Tonocebrinon works

Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature.

Toxicity

Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.

Food Interaction

No interactions found.

Elimination Route

Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism.

Innovators Monograph

You find simplified version here Tonocebrinon

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000265
http://classyfire.wishartlab.com/tax_nodes/C0000013
http://classyfire.wishartlab.com/tax_nodes/C0004323
http://classyfire.wishartlab.com/tax_nodes/C0004146
http://classyfire.wishartlab.com/tax_nodes/C0000489
http://classyfire.wishartlab.com/tax_nodes/C0000346
http://classyfire.wishartlab.com/tax_nodes/C0004176
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16015
http://www.genome.jp/dbget-bin/www_bget?cpd:C00025
http://www.hmdb.ca/metabolites/HMDB0000148
http://www.genome.jp/dbget-bin/www_bget?drug:D00007
http://www.genome.jp/dbget-bin/www_bget?cpd:C00025
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=33032
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505816
https://www.chemspider.com/Chemical-Structure.30572.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17657
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=25916
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=16015
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL575060
https://zinc.docking.org/substances/ZINC000001482113
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000015
http://www.pharmgkb.org/drug/PA449776
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/GGL
https://en.wikipedia.org/wiki/Glutamic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
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