Tonocebrinon
Tonocebrinon Uses, Dosage, Side Effects, Food Interaction and all others data.
A peptide that is a homopolymer of glutamic acid.
In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.
| Trade Name | Tonocebrinon |
| Generic | Glutamic acid |
| Glutamic acid Other Names | ácido glutámico, Glutamic acid |
| Type | |
| Formula | C5H9NO4 |
| Weight | Average: 147.1293 Monoisotopic: 147.053157781 |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Georgia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tonocebrinon is an amino acid commonly found as a component in total parenteral nutrition.
Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Tonocebrinon is also used to associated treatment for these conditions: Amino acid supplementation
How Tonocebrinon works
Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature.
Toxicity
Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.
Food Interaction
No interactions found.Elimination Route
Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism.
Innovators Monograph
You find simplified version here Tonocebrinon
