Top Np
Top Np Uses, Dosage, Side Effects, Food Interaction and all others data.
Top Np is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
| Trade Name | Top Np |
| Generic | Nimesulide |
| Nimesulide Other Names | Nimesulida, Nimesulide, Nimesulidum |
| Weight | 100mg |
| Type | Tablet |
| Formula | C13H12N2O5S |
| Weight | Average: 308.31 Monoisotopic: 308.046692194 |
| Protein binding | >97.5% |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Henry Pharmaceuticals |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Top Np is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea
Top Np is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs
How Top Np works
The therapeutic effects of Top Np are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Dosage
Top Np dosage
100 mg twice daily.Should be taken with food. Take after meals.
Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Precaution
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Interaction
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
1.8–4.7 hours
Elimination Route
Renal (50%), fecal (29%)
Pregnancy & Breastfeeding use
Category not classified
Contraindication
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Acute Overdose
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage Condition
Protect from heat and humidity; store at <25°C.
Innovators Monograph
You find simplified version here Top Np
FAQ
What is Top Np used for?
Top Np is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.
how safe Top Np is?
It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.
What are the common side effect of Top Np ?
Top Np is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Is Top Np bad for liver?
Top Np must be withdrawn worldwide due to serious liver damage.Top Np exposes patients to fatal liver damage.
How quickly does Top Np work?
Top Np works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.
Is Top Np safe during pregnancy?
Our study suggests that the use of Top Np in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.
Can I take Top Np while breastfeeding?
The action of Top Np on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that Top Np is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.
Can I take Top Np safe with alcohol?
Avoid consuming alcohol while taking Top Np as it can increase your risk of stomach problems.
Does bnrand increase blood pressure?
Our results indicate no difference between Top Np and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Can Top Np be taken empty stomach?
Do not take it on an empty stomach.Always take Top Np together with food or immediately after a meal.
Is Top Np safe for kidneys?
This observation indicates that Top Np can provoke acute renal failure as a result of an obstructive crystalline nephropathy.
Can heart patients take Top Np?
Top Np should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.
Is Top Np good for headache?
Top Np with Paracetamol is used for pain relief.
Is Top Np used for migraine?
Top Np has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.
Can Top Np I take in periods?
Top Np reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.
Can Top Np use for ear pain?
Top Np indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.
Can Top Np cause sleepiness?
Top Np suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy.
Can Top Np be used for throat pain?
Top Np which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.
Is Top Np safe for adults?
Top Np may safe for adult if Top Np recommended dose in 100 mg twice daily for no more than 15 days.
How bad is bnand?
Top Np must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.
Can I take Top Np for a long time?
Top Np is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.
Can I drive after taking Top Np?
Top Np may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.
