Topcare Childrens Allergy Relief 24 Hour
Topcare Childrens Allergy Relief 24 Hour Uses, Dosage, Side Effects, Food Interaction and all others data.
Topcare Childrens Allergy Relief 24 Hour is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1-receptors on effector cells.
Like other 2nd generation antihistamines, loratadine is selective for peripheral H1 receptors. Topcare Childrens Allergy Relief 24 Hour does not penetrate effectively into the central nervous system and has poor affinity for CNS H1-receptors. These qualities result in a lack of CNS depressant effects such as drowsiness, sedation, and impaired psychomotor function.
| Trade Name | Topcare Childrens Allergy Relief 24 Hour |
| Availability | Rx and/or OTC |
| Generic | Loratadine |
| Loratadine Other Names | Loratadina, Loratadine, Loratadinum |
| Related Drugs | prednisone, hydroxyzine, cetirizine, fluticasone nasal, montelukast, promethazine, diphenhydramine, triamcinolone, Benadryl, Zyrtec |
| Type | Tablet, orally disintegrating |
| Formula | C22H23ClN2O2 |
| Weight | Average: 382.883 Monoisotopic: 382.144805697 |
| Protein binding | 97 - 99% of the loratadine is bound to plasma proteins. |
| Groups | Approved, Investigational |
| Therapeutic Class | Non-sedating antihistamines |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Topcare Childrens Allergy Relief 24 Hour provides faster relief from the symptoms of hay fever, allergic rhinitis such as sneezing, nasal discharge, itching, ocular itching and burning, nasal and ocular sign and symptoms are relieved rapidly after oral administration.
Topcare Childrens Allergy Relief 24 Hour is also effective in idiopathic chronic urticaria. In children over 2 years, Topcare Childrens Allergy Relief 24 Hour is used for the symptomatic relief of seasonal allergic rhinitis and allergic skin conditions such as urticaria nettle rash.
Topcare Childrens Allergy Relief 24 Hour is also used to associated treatment for these conditions: Allergic Dermatologic Disorders, Allergic Rhinitis (AR), Allergies, Chronic Urticaria, Common Cold, Eye pruritus, Fever, Nasal Congestion, Nasal Itching, Pain, Perennial Allergic Rhinitis (PAR), Perennial Rhinitis, Pollen Allergy, Pruritus, Rhinorrhoea, Seasonal Allergic Rhinitis, Sneezing, Sensation of burning in the eyes, Watery eyes, Watery itchy eyes
How Topcare Childrens Allergy Relief 24 Hour works
Histamine release is a key mediator in allergic rhinitis and urticaria. As a result, loratadine exerts it's effect by targeting H1 histamine receptors.
Topcare Childrens Allergy Relief 24 Hour binds to H1 histamine receptors found on the surface of epithelial cells, endothelial cells, eosinophils, neutrophils, airway cells, and vascular smooth muscle cells among others. H1 histamine receptors fall under the wider umbrella of G-protein coupled receptors, and exist in a state of equilibrium between the active and inactive forms. Histamine binding to the H1-receptor facilitates cross linking between transmembrane domains III and V, stabilizing the active form of the receptor. On the other hand, antihistamines bind to a different site on the H1 receptor favouring the inactive form.
Hence, loratadine can more accurately be classified as an "inverse agonist" as opposed to a "histamine antagonist", and can prevent or reduce the severity of histamine mediated symptoms.
Dosage
Topcare Childrens Allergy Relief 24 Hour dosage
Adult & children over 12 years of age: One Topcare Childrens Allergy Relief 24 Hour 10 mg tablet once daily (usually in the morning).
Children:
- 2-12 years (body weight more than 30 Kg): 10 mg Topcare Childrens Allergy Relief 24 Hour once daily.
- 2-12 years (body weight less than 30 Kg): 5 mg Topcare Childrens Allergy Relief 24 Hour once daily.
- Below 2 years of age: Safety and efficacy of Topcare Childrens Allergy Relief 24 Hour have not been established.
Liver & renal impairment: Patients with liver impairment and renal insufficiency (GFR <30 ml/min) should be given a lower initial dose (10 mg every other day).
Side Effects
Fatigue, nausea and headache were reported rarely. Scientific studies showed that Topcare Childrens Allergy Relief 24 Hour does not cause drowsiness. It does not affect performance and ability to drive or tasks requiring concentration.
Toxicity
Second generation antihistamines such as loratadine have very few adverse effects; however, insomnia, headache, fatigue, drowsiness and rash have been reported. Symptoms of loratadine overdose include gastrointestinal side effects, agitation, drowsiness, tachycardia, and headache. It is advised to obtain an ECG in the event of loratadine overdose.
Precaution
Patients with liver impairment and renal insufficiency (GFR <30 ml/min) should be given a lower initial dose (10 mg every other day).
Interaction
When administered concurrently with alcohol, Topcare Childrens Allergy Relief 24 Hour has no potentiating effect as measured by psychomotor performance studies. Interactions with other drugs have not been reported.
Food Interaction
No interactions found.[Minor] Theoretically, grapefruit juice may increase the plasma concentrations of loratadine as it does other drugs that are substrates of the CYP450 3A4 enzymatic pathway.
The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.
The clinical significance of this potential interaction is unknown.
Reported interactions with potent CYP450 3A4 inhibitors like clarithromycin, erythromycin and ketoconazole have produced substantial increases in the area under the plasma concentration-time curve (AUC) of loratadine and its active metabolite, descarboethoxyloratadine, without associated changes in the overall safety profile of the drug.
Topcare Childrens Allergy Relief 24 Hour Drug Interaction
Unknown: fluticasone / salmeterol, aspirin, aspirin, diphenhydramine, ubiquinone, duloxetine, omega-3 polyunsaturated fatty acids, fluticasone nasal, pregabalin, metoprolol, metoprolol, polyethylene glycol 3350, albuterol, montelukast, budesonide / formoterol, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol
Topcare Childrens Allergy Relief 24 Hour Disease Interaction
Volume of Distribution
The volume of distribution of loratadine is 120 L/Kg.
Elimination Route
Topcare Childrens Allergy Relief 24 Hour is rapidly absorbed and achieves peak plasma concentration in 1-2 hours, while it's main metabolite achieves peak plasma concentration in 3-4 hours.
In the rapid dissolve formulation, the pharmacokinetic parameters of loratadine are as follows: Cmax = 2.56 ng/ml, Tmax = 1.14 hrs, AUC = 6.14 ng x hr/ml.
In the rapid dissolve formulation, the pharmacokinetic parameters of descarboethoxyloratadine are as follows: Cmax = 3.72 ng/ml, Tmax = 1.97 hr, AUC = 49.1 ng x hr/ml.
In the conventional formulation, the pharmacokinetic parameters of loratadine are as follows: Cmax = 2.11 ng/ml, Tmax = 1.00 hr, AUC = 4.64 ng x hr/ml
In the conventional formulation, the pharmacokinetic parameters of descarboethoxyloratadine are as follows: Cmax = 3.66 ng/ml, Tmax = 1.97 hr, AUC = 48.4 ng x hr/ml
Half Life
The elimination half life is approximately 10 hours for loratadine and 20 hours for descarboethoxyloratadine.
Clearance
The clearance of loratadine after single oral doses of 20 mg and 40 mg are 12 L/h/kg and 9 L/h/kg respectively. P-glycoprotein is involved in the clearance of many 2nd generation antihistamines, including loratadine, from the central nervous system. 1st generation antihistamines are not cleared by P-glycoprotein, which may help explain why they have a different central nervous system adverse effect profile compared to their 2nd generation counterparts. It appears that an antihistamine with higher affinity for p-glycoprotein will have a lower incidence of CNS adverse effects.
Elimination Route
Over a 10 day period, 40% of loratadine is excreted in the urine, and 42% is eliminated in the faeces.
Pregnancy & Breastfeeding use
Use in pregnancy: There is no experience of the use of Topcare Childrens Allergy Relief 24 Hour in human pregnancy, hence it should not be used during pregnancy.
Use in lactation: Topcare Childrens Allergy Relief 24 Hour is excreted in breast milk, so it should not be administered to lactating mother.
Contraindication
Topcare Childrens Allergy Relief 24 Hour is contraindicated in patients who have shown hypersensitivity or idiosyncracy to their components.
Acute Overdose
Symptoms: Somnolence, tachycardia headache, drowsiness, extrapyramidal manifestations and palpitations.
Management: Symptomatic and supportive treatment. Immediately empty stomach by inducing emesis with ipecac syrup. Admin of activated charcoal after emesis may be useful. If induction of vomiting is unsuccessful or contraindicated (e.g. patient is comatose, having seizures or lacks gag reflex), gastric lavage with NaCl 0.9% soln may be performed to prevent aspiration of gastric contents. Saline cathartics may be useful to rapidly dilute bowel contents.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Topcare Childrens Allergy Relief 24 Hour
Topcare Childrens Allergy Relief 24 Hour contains Loratadine see full prescribing information from innovator Topcare Childrens Allergy Relief 24 Hour Monograph, Topcare Childrens Allergy Relief 24 Hour MSDS, Topcare Childrens Allergy Relief 24 Hour FDA label
FAQ
What is Topcare Childrens Allergy Relief 24 Hour used for?
Topcare Childrens Allergy Relief 24 Hour is used to treat sneezing, runny nose, watery eyes, hives, skin rash, hay fever, itching, and other cold or allergy symptoms. It's also used to treat hay fever.
How safe is Topcare Childrens Allergy Relief 24 Hour?
Generally, it's considered safe to use Topcare Childrens Allergy Relief 24 Hour for a long time, but you should only take it if you need it.Depending on your condition, you may only need to use Topcare Childrens Allergy Relief 24 Hour for a short period of time, or you might need to take it longer to treat stubborn allergies.
How does Topcare Childrens Allergy Relief 24 Hour work?
Topcare Childrens Allergy Relief 24 Hour works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
What are the common side effects of Topcare Childrens Allergy Relief 24 Hour?
Common side effects of Topcare Childrens Allergy Relief 24 Hour are include:
- headache
- dry mouth
- nosebleed
- sore throat
- mouth sores
- difficulty falling asleep or staying asleep
- nervousness
- weakness
- stomach pain
- diarrhea
- red or itchy eyes
Is Topcare Childrens Allergy Relief 24 Hour safe during pregnancy?
Topcare Childrens Allergy Relief 24 Hour can be taken in pregnancy. There is no good evidence that it can harm your baby.
Is Topcare Childrens Allergy Relief 24 Hour safe during breastfeeding?
Considering the minimal exposure of a nursing infant to the drugs through breast milk, maternal use of Topcare Childrens Allergy Relief 24 Hour in a standard therapeutic dose is unlikely to result in adverse effects in nursing infants and is considered to be compatible with breastfeeding.
Can I drink alcohol with Topcare Childrens Allergy Relief 24 Hour?
If you take an allergy medication like Topcare Childrens Allergy Relief 24 Hour, you may be at risk of drowsiness and confusion if you drink alcohol.
Can I drive after taking Topcare Childrens Allergy Relief 24 Hour?
Topcare Childrens Allergy Relief 24 Hour is classed as a non-drowsy antihistamine but it's still possible to feel sleepy after taking it. If this happens to you, do not drive a car or ride a bike until you feel better.
When is the best time to take Topcare Childrens Allergy Relief 24 Hour?
Take Topcare Childrens Allergy Relief 24 Hour once a day at the same time each day, either in the morning or in the evening. You can take Topcare Childrens Allergy Relief 24 Hour with or without food.
Is it safe to take Topcare Childrens Allergy Relief 24 Hour every day?
Topcare Childrens Allergy Relief 24 Hour is safe to take daily.
Can I take Topcare Childrens Allergy Relief 24 Hour on an empty stomach?
You may take Topcare Childrens Allergy Relief 24 Hour with food or on an empty stomach.
How long does Topcare Childrens Allergy Relief 24 Hour take to work?
Usually, Topcare Childrens Allergy Relief 24 Hour tablets start to work within 30 minutes after being taken and tend to be most effective within 1-2 hours after being taken.
How long does Topcare Childrens Allergy Relief 24 Hour stay in my system?
The elimination half-life of Topcare Childrens Allergy Relief 24 Hour is 8–14 hours and that of its metabolite is 17–24 hours, which accounts for the 24-hour duration of action of the drug. Wheal inhibition is detected at 1.5 hours after administration, reaches a peak at 4–6 hours, and may last 36–48 hours.
Can I take Topcare Childrens Allergy Relief 24 Hour for a long time?
Yes, you can take Topcare Childrens Allergy Relief 24 Hour daily and long term. Topcare Childrens Allergy Relief 24 Hour is an antihistamine used to treat for allergy symptoms. If your symptoms are year round then it is able to be taken long term. If your symptoms are seasonal or you have allergy symptoms occasionally, then it is taken daily when required.
Who should not take Topcare Childrens Allergy Relief 24 Hour?
You should not take Topcare Childrens Allergy Relief 24 Hour if you have any symptom of bellow:
- liver failure.
- liver problems.
- moderate to severe kidney impairment.
What happens if I miss a dose?
Topcare Childrens Allergy Relief 24 Hour is used when needed. Do not use Topcare Childrens Allergy Relief 24 Hour more than once in a 24-hour period. Do not use two doses at one time.
What happens if I overdose on Topcare Childrens Allergy Relief 24 Hour?
Overdose symptoms may include headache, drowsiness, and fast or pounding heartbeat.Seek emergency medical attention.
How quickly does Topcare Childrens Allergy Relief 24 Hour work?
Topcare Childrens Allergy Relief 24 Hour reaches peak plasma concentration in 1-2 hours; the metabolite does so in 3-4 hours. Their respective elimination half-lives are about 10 and 20 hours. Onset of action is within 1 hour and duration is at least 24 hour.
Can Topcare Childrens Allergy Relief 24 Hour affect fertility?
They found Topcare Childrens Allergy Relief 24 Hour could have negative long-term side effects for male fertility.
Is Topcare Childrens Allergy Relief 24 Hour safe for heart patients?
Newer Topcare Childrens Allergy Relief 24 Hour like Topcare Childrens Allergy Relief 24 Hour are all fairly safe for the heart, with fexofenadine seeming to be the absolute safest if you are at risk of arrythmia.
Does Topcare Childrens Allergy Relief 24 Hour affect blood pressure?
Topcare Childrens Allergy Relief 24 Hour increase your blood pressure and heart rate.
Can Topcare Childrens Allergy Relief 24 Hour affects my liver?
Patients with liver disease may be at greater risk for adverse effects from Topcare Childrens Allergy Relief 24 Hour due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function.
Can I just stop taking Topcare Childrens Allergy Relief 24 Hour?
Exposure to substances such as pollen, pet fur, house dust or insect bites can cause your body to produce allergic symptoms. Cells in the lining of your nose and eyes release histamine when they come into contact with these substances.
