Topdom

Topdom Uses, Dosage, Side Effects, Food Interaction and all others data.

Topdom is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Topdom is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Trade Name Topdom
Generic Domperidone
Domperidone Other Names Domperidona, Domperidone, Domperidonum
Type Capsule
Formula C22H24ClN5O2
Weight Average: 425.911
Monoisotopic: 425.161852744
Protein binding

91%-93%

Groups Approved, Investigational, Vet approved
Therapeutic Class Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer Cachet Pharmaceuticals Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Topdom
Topdom

Uses

Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Topdom is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders

How Topdom works

Topdom acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Topdom facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting

Dosage

Topdom dosage

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Topdom tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.

Side Effects

Topdom may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Toxicity

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Precaution

Topdom should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Interaction

Topdom may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Topdom on gastrointestinal function.

Food Interaction

  • Take before a meal. Take 15-30 minutes before meals.

Half Life

7 hours

Pregnancy & Breastfeeding use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Topdom may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Contraindication

Topdom is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

Innovators Monograph

You find simplified version here Topdom

Topdom contains Domperidone see full prescribing information from innovator Topdom Monograph, Topdom MSDS, Topdom FDA label

FAQ

What is Topdom used for?

Topdom help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Topdom is sometimes used to increase milk supply.

Is Topdom safe to take?

For most people, taking Topdom is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.

What are the side effects of Topdom?

Common side effects of Topdom are include:

  • swelling of the ankles/feet.
  • unusual tiredness.
  • mental/mood changes (e.g., nervousness, irritability)
  • hot flashes.
  • breast swelling/pain.
  • unusual leakage of milk from the breast.
  • changes in menstrual periods.
  • decreased sexual ability.

Is Topdomsafe during pregnancy?

Topdom is not usually recommended in pregnancy.

Why Topdom is not safe in pregnancy?

Topdom is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.

Is Topdom safe during breastfeeding?

A very small amount of the Topdom you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Topdom.

Can I drink alcohol with Topdom?

It is best to avoid alcohol when taking Topdom. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.

How long does Topdom take to work?

Topdom often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.

Can I take Topdom before bed?

Topdom is best taken 15 to 30 minutes before meals and id necessary at bedtime.

Is Topdom good for acid reflux?

It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.

Can I take Topdom after eating?

Topdom is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Topdom after a meal, it will still work, but it may take longer to have an effect.

Is Topdom good for gastritis?

Topdom has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Topdom is a kind of drug to strengthen gastric motility.

What does Topdom do to your body?

Topdom is a medicine that increases the movements or contractions of the stomach and bowel. Topdom is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Is Topdom safe for kidneys?

Topdom are not significantly renally cleared and can be used in CKD.

Does Topdom help anxiety?

Topdom is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.

Does Topdom raise blood pressure?

Topdom increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Topdom a narcotic?

Topdom is not a controlled substance e.g. sleeping pills, valium, narcotics.

Does Topdom cause depression?

Topdom can cause central nervous system side effects such as fatigue, irritability, or depression.

Can I take Topdom for a long time?

You should usually take Topdom for up to a week.Because Topdom can cause an irregular heartbeat if you take it for longer or at a high dose.

What happens when I stop taking Topdom?

Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Topdom slowly.

*** Taking medicines without doctor's advice can cause long-term problems.
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