Topicort Lp

Topicort Lp Uses, Dosage, Side Effects, Food Interaction and all others data.

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Topicort Lp is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

Topicort Lp
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Topicort Lp
Generic	Desoximetasone
Desoximetasone Other Names	Deoxymethasone, Desoximetason, Desoximetasona, Désoximétasone, Desoximetasone, Desoximetasonum, Desoxymethasone
Weight	0.05%, 0.25%,
Type	Topical cream, topical gel, topical ointment, topical spray
Formula	C₂₂H₂₉FO₄
Weight	Average: 376.4617 Monoisotopic: 376.204987621
Protein binding	Bound to plasma proteins in varying degrees.
Groups	Approved
Therapeutic Class	Other Topical corticosteroids
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Topicort Lp Emollient Cream used for the relief of the inflammatory and pruritic manifestations of corticosteroid-inflammatory and pruritic manifestations of corticosteroid

Topicort Lp is also used to associated treatment for these conditions: Allergic Contact Dermatitis, Dermatitis, Eczematous, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Corticosteroid-responsive dermatoses

How Topicort Lp works

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A₂ inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂.

Dosage

Topicort Lp dosage

Apply a thin film of Topicort Lp Emollient Cream to the affected skin areas twice daily. Rub ingently

Toxicity

Topically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

Food Interaction

No interactions found.

Elimination Route

Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

Half Life

The half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.

Elimination Route

Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.Pharmacokinetic studies in men with Topicort Lp Cream USP, 0.25% with tagged desoximetasone showed a total of 5.2% ± 2.9% excretion in urine (4.1% ± 2.3%) and feces (1.1% ± 0.6%)