Topifuran 0.2%

Topifuran 0.2% Uses, Dosage, Side Effects, Food Interaction and all others data.

A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis.

Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.

Trade Name Topifuran 0.2%
Generic Nitrofural
Nitrofural Other Names Furacilin, Nitrofural
Type
Formula C6H6N4O4
Weight Average: 198.1362
Monoisotopic: 198.0389047
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country Egypt
Last Updated: September 19, 2023 at 7:00 am
Topifuran 0.2%
Topifuran 0.2%

Uses

Topifuran 0.2% is a topical antibacterial for the prevention and treatment of bacterial infections of the skin.

For the treatment of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.

Topifuran 0.2% is also used to associated treatment for these conditions: Skin Infections

How Topifuran 0.2% works

The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.

Toxicity

Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.

Elimination Route

Well absorbed.

Half Life

5 hours

Innovators Monograph

You find simplified version here Topifuran 0.2%

*** Taking medicines without doctor's advice can cause long-term problems.
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