Toplap
Toplap Uses, Dosage, Side Effects, Food Interaction and all others data.
A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
| Trade Name | Toplap |
| Generic | Prilocaine + Lidocaine / Lignocaine |
| Weight | 2.5% |
| Type | Cream, Gel |
| Therapeutic Class | |
| Manufacturer | Curatio Healthcare India Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Prilocaine is a local anesthetic used in dental procedures.
Used as a local anaesthetic and is often used in dentistry.
Toplap is also used to associated treatment for these conditions: Local anesthesia therapy
How Toplap works
Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Elimination Route
Prilocaine is metabolized in both the liver and the kidney and excreted via the kidney.
Innovators Monograph
You find simplified version here Toplap
