Torecan
Torecan Uses, Dosage, Side Effects, Food Interaction and all others data.
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Torecan, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, Torecan binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
| Trade Name | Torecan |
| Availability | Discontinued |
| Generic | Thiethylperazine |
| Thiethylperazine Other Names | Norzine, Thiethylperazin, Thiéthylpérazine, Thiethylperazine, Thiethylperazinum, Tietilperazina |
| Related Drugs | hydroxyzine, lorazepam, ondansetron, Zofran, meclizine, promethazine |
| Weight | 6.5mg/ml, |
| Type | Injection |
| Formula | C22H29N3S2 |
| Weight | Average: 399.616 Monoisotopic: 399.180289323 |
| Protein binding | 60% |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | Novartis Pharma (pak) Ltd, Novartis Pharma |
| Available Country | Pakistan, United States, Switzerland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Torecan is a drug used for the treatment of nausea and vomiting.
For the treatment or relief of nausea and vomiting.
Torecan is also used to associated treatment for these conditions: Nausea and vomiting
How Torecan works
Torecan is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Torecan's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Torecan does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with thiethylperazine.
Toxicity
Manifestations of acute overdosage of TORECAN (thiethylperazine) can be expected to reflect the CNS effects of the drug and include extrapyramidal symptoms (E.P.S), confusion and convulsions with reduced or absent reflexes, respiratory depression and hypotension.
Torecan Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Torecan Drug Interaction
Major: tramadolModerate: meperidine, ethanol, lithium, sotalolUnknown: amoxicillin / clavulanate, multivitamin, sulfamethoxazole / trimethoprim, ubiquinone, copper gluconate, glucose, glycerin, heparin, arginine, levocarnitine, cysteine, acetaminophen, bioflavonoids, vitamin a topical, bioflavonoids
Torecan Disease Interaction
Major: acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Elimination Route
Torecan is eliminated in the urine.
Innovators Monograph
You find simplified version here Torecan
