Tositumomab

Tositumomab Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).

Tositumomab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.

Table Of contents

• Tositumomab
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Tositumomab
Availability	Prescription only
Generic	Tositumomab
Tositumomab Other Names	Tositumomab
Related Drugs	methotrexate, rituximab, glucagon, Rituxan, cyclophosphamide, mannitol, vincristine, Imbruvica, Tubersol
Type
Formula	C6416H9874N1688O1987S44
Weight	143859.7 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Tositumomab is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)

How Tositumomab works

Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.

Half Life

0.8 hours (mammalian reticulocytes, in vitro)

Clearance

• 68.2 mg/hr [patients with NHL]

Elimination Route

Elimination of Iodine-131 occurs by decay and excretion in the urine.

Innovators Monograph

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