Tplase IV Injection 5 mg/ml

Tplase IV Injection 5 mg/ml Uses, Dosage, Side Effects, Food Interaction and all others data.

Tplase IV Injection 5 mg/ml is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese Hamster Ovary cells). Tplase IV Injection 5 mg/ml is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain. Tenectaplase is a sterile, white to off-white, lyophilized powder for single intravenous (IV) bolus administration after reconstitution with Sterile Water for Injection (SWFI), USP. Each vial of Tenectaplase nominally contains 52.5 mg Tplase IV Injection 5 mg/ml, 0.55 g L-arginine, 0.17 g phosphoric acid, and 4.3 mg polysorbate 20, which includes a 5% overfill. Each vial will deliver 50 mg of Tplase IV Injection 5 mg/ml. Tplase IV Injection 5 mg/ml is a modified form of human tissue plasminogen activator (tPA) that binds to fibrin and converts plasminogen to plasmin. In the presence of fibrin, in vitro studies demonstrate that Tplase IV Injection 5 mg/ml conversion of plasminogen to plasmin is increased relative to its conversion in the absence of fibrin. This fibrin specificity decreases systemic activation of plasminogen and the resulting degradation of circulating fibrinogen as compared to a molecule lacking this property. Following administration of 30, 40, or 50 mg of Tplase IV Injection 5 mg/ml, there are decreases in circulating fibrinogen (4%-15%) and plasminogen (11%-24%). The clinical significance of fibrinspecificity on safety (e.g., bleeding) or efficacy has not been established. Biological potency is determined by an in vitro clot lysis assay and is expressed in Tplase IV Injection 5 mg/ml-specific units. The specific activity of Tplase IV Injection 5 mg/ml has been defined as 200 units/mg.

Tplase IV Injection 5 mg/ml is a fibrin-specific tissue-plasminogen activator. It binds to fibrin rich clots and cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.

Trade Name Tplase IV Injection 5 mg/ml
Availability Prescription only
Generic Tenecteplase
Tenecteplase Other Names Tenecteplasa, Tenecteplase, TNK-tPA
Related Drugs aspirin, lisinopril, metoprolol, propranolol, Plavix, Brilinta
Weight 5 mg/ml
Type IV Injection
Formula C2561H3919N747O781S40
Weight 58951.2 Da
Groups Approved
Therapeutic Class Fibrinolytics (Thrombolytics)
Manufacturer Healthcare Pharmaceuticals Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Tplase IV Injection 5 mg/ml
Tplase IV Injection 5 mg/ml

Uses

Tplase IV Injection 5 mg/ml is used for use in the reduction of mortality associated with acute myocardial infarction (AMI). Treatment should be initiated as soon as possible after the onset of acute myocardial infarction symptoms.
Pediatric Use: The safety and effectiveness of Tplase IV Injection 5 mg/ml in pediatric patients have not been established.

In elderly patients: The benefits of Tplase IV Injection 5 mg/ml on mortality should be carefully weighed against the risk of increased adverse events, including bleeding.

Tplase IV Injection 5 mg/ml is also used to associated treatment for these conditions: ST Elevation Myocardial Infarction (STEMI)

How Tplase IV Injection 5 mg/ml works

Tplase IV Injection 5 mg/ml binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

Dosage

Tplase IV Injection 5 mg/ml dosage

Tplase IV Injection 5 mg/ml is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight. A single bolus dose should be administered over 5 seconds based on patient weight. Treatment should be initiated as soon as possible after the onset of AMI symptoms.

  • Patient Weight <60 kg: 30 mg Tplase IV Injection 5 mg/ml 
  • Patient Weight ≥60 to <70 kg: 35 mg Tplase IV Injection 5 mg/ml 
  • Patient Weight ≥70 to <80 kg: 40 mg Tplase IV Injection 5 mg/ml 
  • Patient Weight ≥80 to <90 kg: 45 mg Tplase IV Injection 5 mg/ml 
  • Patient Weight ≥90 kg: 50 mg Tplase IV Injection 5 mg/ml

  1. The product should be visually inspected prior to administration for particulate matter and discoloration. Tplase IV Injection 5 mg/ml may be administered as reconstituted at 5 mg/mL.
  2. Precipitation may occur when Tplase IV Injection 5 mg/ml is administered in an IV line containing dextrose. Dextrose-containing lines should be flushed with a saline-containing solution prior to and following single bolus administration of Tplase IV Injection 5 mg/ml.
  3. Reconstituted Tplase IV Injection 5 mg/ml should be administered as a single IV bolus over 5 seconds.
  4. Because Tplase IV Injection 5 mg/ml contains no antibacterial preservatives, it should be reconstituted immediately before use. If the reconstituted Tplase IV Injection 5 mg/ml is not used immediately, refrigerate the Tplase IV Injection 5 mg/ml vial at 2-8°C and use within 8 hours.
  5. Although the supplied syringe is compatible with a conventional needle, this syringe is designed to be used with needleless IV systems. From the information below, follow the instructions applicable to the IV system in use.

Side Effects

The most frequent adverse reaction associated with Tplase IV Injection 5 mg/ml is bleeding. Should serious bleeding occur, concomitant heparin and antiplatelet therapy should be discontinued. Death or permanent disability can occur in patients who experience stroke or serious bleeding episodes. For Tplase IV Injection 5 mg/ml-treated patients in ASSENT-2, the incidence of intracranial hemorrhage was 0.9% and any stroke was 1.8%. The incidence of all strokes, including intracranial bleeding, increases with increasing age

Precaution

General: Standard management of myocardial infarction should be implemented concomitantly with Tplase IV Injection 5 mg/ml treatment. Arterial and venous punctures should be minimized. Noncompressible arterial puncture must be avoided and internal jugular and subclavian venous punctures should be avoided to minimize bleeding from the noncompressible sites. In the event of serious bleeding, heparin and antiplatelet agents should be discontinued immediately. Heparin effects can be reversed by protamine.

Readministration: Readministration of plasminogen activators, including Tplase IV Injection 5 mg/ml, to patients who have received prior plasminogen activator therapy has not been systematically studied. Three of 487 patients tested for antibody formation to Tplase IV Injection 5 mg/ml had a positive antibody titer at 30 days. The data reflect the percentage of patients whose test results were considered positive for antibodies to Tplase IV Injection 5 mg/ml in a radioimmunoprecipitation assay, and are highly dependent on the sensitivity and specificity of the assay. Additionally, the observed incidence of antibody positivity in an assay may be influenced by several factors including sample handling, concomitant medications, and underlying disease. For these reasons, comparison of the incidence of antibodies to Tplase IV Injection 5 mg/ml with the incidence of antibodies to other products may be misleading. Although sustained antibody formation in patients receiving one dose of Tplase IV Injection 5 mg/ml has not been documented, readministration should be undertaken with caution.

Hypersensitivity: Hypersensitivity, including urticarial / anaphylactic reactions, have been reported after administration of Tplase IV Injection 5 mg/ml (e.g., anaphylaxis, angioedema, laryngeal edema, rash, and urticaria). Monitor patients treated with Tplase IV Injection 5 mg/ml during and for several hours after infusion. If symptoms of hypersensitivity occur, appropriate therapy should be initiated.

Interaction

Formal interaction studies of Tenectaplase with other drugs have not been performed. Patients studied in clinical trials of Tplase IV Injection 5 mg/ml were routinely treated with heparin and aspirin. Anticoagulants (such as heparin and vitamin K antagonists) and drugs that alter platelet function. (such as acetylsalicylic acid, dipyridamole, and GP IIb/IIIa inhibitors) may increase the risk of bleeding if administered prior to, during, or after Tenectaplase therapy.

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Tplase IV Injection 5 mg/ml Hypertension interaction

[Major] The most common complication encountered during tenecteplase therapy is bleeding.

Tplase IV Injection 5 mg/ml therapy in patients with acute myocardial infarction is contraindicated in patients with active internal bleeding, history of cerebrovascular accident, intracranial or intraspinal surgery or trauma within 2 months, intracranial neoplasms, arteriovenous malformations or aneurysm, bleeding diathesis or severe uncontrolled hypertension, due to an increased risk of bleeding.

Each patient being considered for therapy should be carefully evaluated and anticipated benefits weighed against potential risks associated with therapy.

Tplase IV Injection 5 mg/ml Disease Interaction

Major: Tenecteplase -bleedingModerate: thromboembolism

Half Life

1.9 hours (mammalian reticulocytes, in vitro) >20 hours (yeast, in vivo) >10 hours (Escherichia coli, in vivo)

Clearance

  • 99 - 119 mL/min [acute myocardial infarction patients]

Pregnancy & Breastfeeding use

Pregnancy: Tenectaplase has been shown to elicit maternal and embryo toxicity in rabbits given multiple IV administrations. In rabbits administered 0.5, 1.5, and 5.0 mg/kg/day during organogenesis, vaginal hemorrhage resulted in maternal deaths. Subsequent embryonic deaths were secondary to maternal hemorrhage and no fetal anomalies were observed. Tenectaplase does not elicit maternal and embryo toxicity in rabbits following a single IV administration. Thus, in developmental toxicity studies conducted in rabbits, the no observable effect level (NOEL) of a single IV administration of Tenectaplase on maternal or developmental toxicity (5 mg/kg) was approximately 7 times human exposure (based on AUC) at the dose for AMI. There are no adequate and well controlled studies in pregnant women. Tenectaplase should be given to pregnant women only if the potential benefits justify the potential risk to the fetus.

Nursing Mothers: It is not known if Tenectaplase is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Tenectaplase is administered to a nursing woman.

Contraindication

Tplase IV Injection 5 mg/ml therapy in patients with acute myocardial infarction is contraindicated in the following situations because of an increased risk of bleeding:

  • Active internal bleeding
  • History of cerebrovascular accident
  • Intracranial or intraspinal surgery or trauma within 2 months
  • Intracranial neoplasm, arteriovenous malformation, or aneurysm
  • Known bleeding diathesis
  • Severe uncontrolled hypertension

Storage Condition

Store lyophilized Tplase IV Injection 5 mg/ml at controlled room temperature not to exceed 30°C or under refrigeration 2-8°C. Do not use beyond the expiration date stamped on the vial.

Innovators Monograph

You find simplified version here Tplase IV Injection 5 mg/ml

Tplase IV Injection 5 mg/ml contains Tenecteplase see full prescribing information from innovator Tplase IV Injection 5 mg/ml Monograph, Tplase IV Injection 5 mg/ml MSDS, Tplase IV Injection 5 mg/ml FDA label

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