Tricuran

Tricuran Uses, Dosage, Side Effects, Food Interaction and all others data.

Gallamine triethiodide is a benzylisoquinolinium competitive neuromuscular blocker. It is used to produce muscle relaxation in general anaesthesia during surgical procedures and to aid controlled ventilation.

Tricuran is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.

Tricuran
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Tricuran
Generic	Gallamine Triethiodide
Gallamine Triethiodide Other Names	Gallamin triethiodid, Gallamine triethiodide, Gallamini Triethiodidum, Triéthiodure de Gallamine, Trietioduro de galamina
Type
Formula	C₃₀H₆₀I₃N₃O₃
Weight	Average: 891.5291 Monoisotopic: 891.176873061
Groups	Approved
Therapeutic Class	Non depolarizing muscle relaxants
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Aid controlled ventilation, Anaesthesia, General anaesthesia, Muscle relaxant

How Tricuran works

It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.

Dosage

Tricuran dosage

Aid controlled ventilation, Muscle relaxant in general anaesthesia:

Adult:Test dose: 20 mg may be given before anesth to determine drug sensitivity. Initially, 80-120 mg via IV inj, further doses of 20-40 mg may be given as required.
Child:1.5 mg/kg. Neonates: 600 mcg/kg.

Side Effects

Tachycardia, increased BP.

Precaution

Careful dose titration and monitoring of the degree of block are required to prevent overdosage.

Interaction

Lidocaine, procainamide, quinidine, and verapamil may enhance the block. Clindamycin can prolong the action of muscle relaxants. Apnoea may be prolonged when used with polymyxins. Anticholinesterases or long-term treatment with corticosteroids may antagonise the action of gallamine.