Трифтазина гидрохлорид
Трифтазина гидрохлорид Uses, Dosage, Side Effects, Food Interaction and all others data.
Трифтазина гидрохлорид is one of the phenothiazine class of compounds and as such has many pharmacodynamic effects which relate to its therapeutic actions and side effects. The most notable action of phenothiazines is antagonism at dopamine receptors in the CNS. It is hypothesised that this action in the limbic system and associated areas of cerebral cortex is the basis of the antipsychotic action of phenothiazines, whilst in the medullary chemoreceptor trigger zone it appears to be responsible for the antiemetic effect of these agents.
Трифтазина гидрохлорид is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Трифтазина гидрохлорид has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Trade Name | Трифтазина гидрохлорид |
Availability | Prescription only |
Generic | Trifluoperazine |
Trifluoperazine Other Names | Trifluoperazina, Trifluoperazine, Trifluopérazine, Trifluoperazinum, Trifluoroperazine, Trifluperazine |
Related Drugs | escitalopram, alprazolam, duloxetine, Lexapro, Xanax, quetiapine, Abilify, Cymbalta, Seroquel, aripiprazole |
Type | |
Formula | C21H24F3N3S |
Weight | Average: 407.496 Monoisotopic: 407.164303088 |
Groups | Approved, Investigational |
Therapeutic Class | Phenothiazine drugs |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
![Трифтазина гидрохлорид Трифтазина гидрохлорид](https://www.medicinesfaq.com/media/png/triftazina-gidrohlorid.png)
Uses
Anxiety states: It controls excessive anxiety, tension, and agitation seen in neuroses or associated with somatic conditions. The treatment or prevention of nausea and vomiting of various causes. The management of psychotic disorders, such as acute or chronic catatonic, hebephrenic and paranoid schizophrenia; psychosis due to organic brain damage, toxic psychosis, and the manic phase of manic-depressive illness.
Трифтазина гидрохлорид is also used to associated treatment for these conditions: Agitation, Psychosis, Schizophrenia, Acute non-psychotic Anxiety
How Трифтазина гидрохлорид works
Трифтазина гидрохлорид blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Dosage
Трифтазина гидрохлорид dosage
Schizophrenia and other psychoses:
- Adults and child over 12 years: Recommended starting dose is 2-5 mg b.i.d, increased by 5 mg daily after 1 week then at interval of 3 days, according to response.
- Children (6-12 years): Dosage should be adjusted to the weight of the child and severity of the symptoms. The starting dosage is 1 mg b.i.d. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome. While it is usually not necessary to exceed dosages of 15 mg daily.
- Elderly: Reduce initial dose by at least half
Short-term management of severe anxiety:
- Adult and child over 12 years: 1-2 mg b.i.d, increased if necessary to 6 mg daily.
- Child (3-5 years): 1 mg daily
- Child (6-12 years): Up to 4 mg daily in divided dose.
- Elderly: Reduce initial dose by at least half
Antiemetic:
- Adult: 2-4 mg daily in divided doses; max. 6 mg daily;
- Child 3-5 years: up to 1 mg daily, 6-12 years up to 4 mg daily.
Side Effects
Common side effects are transient restlessness, dystonias or may resemble parkinsonism. Other CNS Reactions are drowsiness, dizziness, fatigue, blurred vision, seizures. Without these Peripheral oedema, blood dyscrasias, jaundice may occasionally occur. Tachycardia, constipation, urinary hesitancy and retention and hyperpyrexia have been reported very rarely.
Toxicity
Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Precaution
Care should be taken when treating elderly patients, and initial dosage should be reduced. Such patients can be specially sensitive, particularly to extra pyramidal and hypotensive effects. Patients with cardiovascular disease including arrhythmias should also be treated with caution. Care should be taken in patients with angina pectoris.
Interaction
Трифтазина гидрохлорид may diminish the effect of oral anticoagulants. Concomitant administration of propranolol with trifluoperazine results in increased plasma levels of both drugs. Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concurrently. Potentiation may occur if antipsychotic drugs are combined with CNS depressants such as alcohol. hypnotics and anticonvulsant.
Food Interaction
- Avoid excessive or chronic alcohol consumption. Ingesting alcohol may potentiate the sedative and CNS depressant effects of trifluoperazine.
Трифтазина гидрохлорид Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Трифтазина гидрохлорид Drug Interaction
Major: escitalopram, topiramateModerate: aripiprazole, amphetamine / dextroamphetamine, duloxetine, clonazepam, lamotrigine, lurasidone, lithium, pregabalin, metoprolol, brexpiprazole, quetiapine, valproic acidUnknown: aspirin, acetaminophen, vortioxetine, multivitamin, ascorbic acid, cholecalciferol
Трифтазина гидрохлорид Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injury, liver damageModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Half Life
10-20 hours
Pregnancy & Breastfeeding use
Pregnancy: Safety for the use of trifluoperazine during pregnancy has not been established. Therefore, it is not recommended that the drug be given to pregnant patients except when, in the judgement of the physician, it is essential. The potential benefits should clearly outweigh possible hazards. There are reported instances of prolonged jaundices, extrapyramidal signs, hyperreflexia or hypoflexia in newborn infants whose mother received phenothiazines.
Lactation: Adequate human data are not available in case of lactation.
Contraindication
Do not use Трифтазина гидрохлорид in comatose patients, or in those with existing blood dyscrasias or known liver damage, or in those hypersensitive to the active ingredient or related compounds.
Acute Overdose
Signs and symptoms will be predominantly extrapyramidal; hypotension may occur. Treatment consists of gastric lavage together with supportive and symptomatic measures. Do not induce vomiting. Extra pyramidal symptoms may be treated with an anticholinergic, antiparkinsonism drug. Treat hypotension with fluid replacement; if severe or persistent. nor adrenaline may be considered. Adrenaline is contraindicated.
Storage Condition
It should be store at room temperature between 15-30° C away from light and moisture.
Innovators Monograph
You find simplified version here Трифтазина гидрохлорид
Трифтазина гидрохлорид contains Trifluoperazine see full prescribing information from innovator Трифтазина гидрохлорид Monograph, Трифтазина гидрохлорид MSDS, Трифтазина гидрохлорид FDA label
FAQ
What is Трифтазина гидрохлорид used for?
Трифтазина гидрохлорид is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).It is also used on a short-term basis to treat anxiety in people who have not been helped by other medications.
How safe is Трифтазина гидрохлорид?
This is the most serious warning from the Food and Drug Administration. A black box warning alerts doctors and patients about drug effects that may be dangerous.Трифтазина гидрохлорид can increase the risk of death in seniors with dementia-related psychosis.
What are the common side effects of Трифтазина гидрохлорид?
Трифтазина гидрохлорид may cause side effects are include.
- dizziness, feeling unsteady, or having trouble keeping your balance
- blurred vision
- dry mouth
- stuffed nose
- nausea
- difficulty urinating
- widening or narrowing of the pupils (black circles in the middle of the eyes)
- constipation
- changes in appetite
- weight gain
- blank facial expression
- shuffling walk
- agitation
- jitteriness
- unusual, slowed, or uncontrollable movements of any part of the body
- difficulty falling asleep or staying asleep
- headache
- extreme tiredness
- weakness
- breast enlargement
- breast milk production
- missed menstrual periods
- decreased sexual ability in men
Is Трифтазина гидрохлорид safe during pregnancy?
Not formally assigned to a pregnancy category. Risk Summary: Neonates exposed during the third trimester are at risk of developing severe and prolonged side effects.
Is Трифтазина гидрохлорид safe during breastfeeding?
A safety scoring system finds Трифтазина гидрохлорид to be not recommended during breastfeeding.Because there is little published experience with Трифтазина гидрохлорид during breastfeeding, other antipsychotic agents may be preferred, especially wile nursing an newborn or preterm infant.
Can I take alcohol with Трифтазина гидрохлорид?
Don't take Трифтазина гидрохлорид with alcohol, as it may increase side effects of Трифтазина гидрохлорид like drowsiness, dizziness and fatigue.
Can I drive after taking Трифтазина гидрохлорид?
Avoid driving or hazardous activity until you know how Трифтазина гидрохлорид will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
How long does it take for Трифтазина гидрохлорид to work?
Although you may notice some medication effects soon after starting, It may take 2 to 3 weeks before you get the full benefit of this drug.
Does Трифтазина гидрохлорид cause weight gain?
Трифтазина гидрохлорид is known to cause a range of adverse reactions including sedation and weight gain, but to a degree far less than other antipsychotics. Other adverse effects include postural hypotension, constipation, parkinsonism, priapism, and sexual dysfunction.
Does Трифтазина гидрохлорид make me sleepy?
Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid drinking alcohol. Avoid exposure to sunlight or tanning beds
Is Трифтазина гидрохлорид an antipsychotic?
Трифтазина гидрохлорид is in a group of medications called conventional antipsychotics.
How to use Трифтазина гидрохлорид?
Take Трифтазина гидрохлорид by mouth with or without food, usually once or twice daily or as directed by your doctor.
What is the half life of Трифтазина гидрохлорид?
The elimination of Трифтазина гидрохлорид from the blood is multiphasic with an α phase elimination half-life of about 3.6 hours and a terminal elimination half-life of about 22 hours.
Does Трифтазина гидрохлорид help with anxiety?
Clinical studies indicate that Трифтазина гидрохлорид produced clinically satisfactory improve- ment in the majority of patients suffering predominantly from anxiety; most of them were treated with only 0.5 mg. or less per day. Studies so far revealed minimal incidence of side effects.
How long does Трифтазина гидрохлорид stay in my system?
Трифтазина гидрохлорид has a half‐life of 6.8 to 9.6 days following IM administration.
How does Трифтазина гидрохлорид work in the body?
It works by affecting the balance of natural chemicals (neurotransmitters) in the brain.
How do I stop taking Трифтазина гидрохлорид?
Do not stop using Трифтазина гидрохлорид suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light.
What happen if I overdose on Трифтазина гидрохлорид?
If an overdose occurs call your doctor.You may need urgent medical care.