Trihydroxypropane
Trihydroxypropane Uses, Dosage, Side Effects, Food Interaction and all others data.
Trihydroxypropane is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.
Trihydroxypropane is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Trihydroxypropane suppositories usually work within 15 to 30 minutes.
| Trade Name | Trihydroxypropane |
| Availability | Rx and/or OTC |
| Generic | Glycerin |
| Glycerin Other Names | Glycerin, Glycerine, glycérine, Glycerinum, Glycerol, glycérol, Glyzerin, Monoctanoin component D, Ölsüß, Propanetriol, Trihydroxypropane |
| Related Drugs | diphenhydramine, Benadryl, benzonatate, MiraLAX, guaifenesin, Colace, docusate, codeine, Linzess, dextromethorphan |
| Type | |
| Formula | C3H8O3 |
| Weight | Average: 92.0938 Monoisotopic: 92.047344122 |
| Groups | Approved, Investigational |
| Therapeutic Class | Osmotic purgatives |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the relief of occasional constipation
Trihydroxypropane is also used to associated treatment for these conditions: Cold Sore, Constipation, Dry Mouth, Dry Skin, Dry throat, Edema of the cerebrum, Hypertension Intracranial, Occasional Constipation, Ocular Discomfort, Ocular Hypertension, Ocular Irritation, Skin Infections, Sore Throat, Mouth soreness, Ocular burning, Bowel preparation therapy, Topical Antisepsis, Skin protection
How Trihydroxypropane works
When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Trihydroxypropane decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.
Dosage
Trihydroxypropane dosage
Children under 2 years: Consult a physician.
Children (2 to 6 years): only 1 Trihydroxypropane 1.15 suppository per 24 hours or as directed by a physician.
Adults and Children (From 6 years): only 1 Trihydroxypropane 2.30 suppository per 24 hours or as directed by a physician
Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.
Side Effects
Trihydroxypropane when used rectally may cause rectal discomfort or a burning sensation
Toxicity
Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg
Food Interaction
No interactions found.Trihydroxypropane Drug Interaction
Unknown: diphenhydramine, menthol/zinc oxide topical, loratadine, docusate, ubiquinone, omega-3 polyunsaturated fatty acids, sodium biphosphate / sodium phosphate, levetiracetam, clonazepam, levocarnitine, magnesium hydroxide, polyethylene glycol 3350, acetaminophen, bifidobacterium infantis / lactobacillus acidophilus, sodium chloride nasal, acetaminophen, cyanocobalamin, pyridoxine, ascorbic acid, cholecalciferol
Trihydroxypropane Disease Interaction
Major: inflammatory bowel disease, intestinal obstruction disorders
Volume of Distribution
Trihydroxypropane is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.
Elimination Route
Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach
Half Life
30 - 45 minutes
Elimination Route
Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.
Pregnancy & Breastfeeding use
Pregnancy category C. There are no controlled data in human pregnancy
Contraindication
Sensitivity to the ingredients. Do not use unless the patient to be treated is, in fact, constipated.
Storage Condition
Store below 25° C. Protect from moisture.
Innovators Monograph
You find simplified version here Trihydroxypropane
FAQ
What is Trihydroxypropane used for?
Trihydroxypropane is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations.
How safe is Trihydroxypropane?
Since Trihydroxypropane is a form of sugar alcohol that your body cannot fully absorb, consuming too much either alone or through foods may also lead to gas and diarrhea. Vegetable glycerin is generally considered safe.
How does Trihydroxypropane work?
Trihydroxypropane works by causing the intestines to hold more water, which softens the stool.
What are the common side effects of Trihydroxypropane?
Common side effects of brad are include:
- Excessive bowel activity.
- Cramping.
- Rectal irritation.
- Cramping rectal pain.
Can I mix alcohol and Trihydroxypropane?
Mix 12 fluid ounces of alcohol with 2 teaspoons of Trihydroxypropane.
What happens if I drink Trihydroxypropane?
When ingested, vegetable Trihydroxypropane may cause headaches, dizziness, nausea, vomiting and excessive thirst in some people.
Is Trihydroxypropane safe during pregnancy?
Trihydroxypropane is only recommended for use during pregnancy when benefit outweighs risk.
Is Trihydroxypropane safe during breastfeeding?
It is not known whether Trihydroxypropane enters breast milk. It is most likely compatible with breastfeeding.
How do I take Trihydroxypropane?
Use your finger or the applicator provided to insert the suppository. Lie on your left side with your lower leg straight and your upper leg bent. Gently insert the suppository pointed tip first into your rectum, about 1/2 inch for a child or 1 inch for an adult. For best results, stay lying down for a few minutes.
How long should Trihydroxypropane take to work?
Trihydroxypropane belongs to a class of drugs known as hyperosmotic laxatives. This effect usually results in a bowel movement within 15 to 60 minutes. For adults, the normal frequency of bowel movements varies from once daily to 1 to 2 times weekly.
When should I take Trihydroxypropane?
For better muscle pumps, take 10–30 grams of Trihydroxypropane with 20–32 ounces of water about one hour before workouts. Also be sure to take creatine with your pre- and postworkout shakes for a synergistic effect.
How often can I take Trihydroxypropane?
Since this medicine is usually given only once as needed, you will not be on a dosing schedule. Do not use Trihydroxypropane rectal more than once in a 24-hour period.
Who should not use Trihydroxypropane?
Stop using glycerin rectal and call your doctor at once if you have: severe stomach pain or cramping; rectal bleeding; or. no bowel movement within 1 hour after use.
Does Trihydroxypropane affect blood pressure?
Trihydroxypropane is used as a peroral treatment of increased intraocular and intracranial pressure due to its osmotic effect despite the potential increase in blood pressure and blood glucose.
Is Trihydroxypropane bad for kidneys?
Trihydroxypropane administration caused severe renal dysfunction, which included marked renal oxidative stress, significantly increased blood urea nitrogen (BUN) and serum creatinine levels.
What happens if I miss a dose?
If you use this medicine on a regular basis, use a missed dose as soon as you think about it.
If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
Do not use 2 doses at the same time or extra doses.
What happens if I overdose?
An overdose of Trihydroxypropane rectal is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.
Can Trihydroxypropane bad for skin?
Trihydroxypropane is typically safe to use on the skin, and many people use cosmetic products containing this ingredient without issue.
Can Trihydroxypropane remove pimples?
Trihydroxypropane cleanses the skin pores and removes dirt. It keeps the skin healthy. Trihydroxypropane reduces acne and keeps the skin pores clean.
Is Trihydroxypropane good for health?
Due to its ability to retain moisture, Trihydroxypropane may be beneficial for skin health, digestive health, and improving athletic performance.
Does Trihydroxypropane darken skin?
No, Trihydroxypropane does not darken your skin. Trihydroxypropane is an ingredient that is actually found in some whitening products.
Does Trihydroxypropane expire?
100% pure Vegetable Trihydroxypropane does not oxidize or go bad, given that it is stored in a none transparent container in a cool, dry place away from sunlight and covered by an airtight lid.
Is Trihydroxypropane good for my hair?
It moisturizes and is known to prevent breakage, especially on hair that isn't chemically treated. Since it helps draw moisture from the air onto your hair and is easily soluble in water, Trihydroxypropane can serve as a great deep conditione.
