Trimakal
Trimakal Uses, Dosage, Side Effects, Food Interaction and all others data.
Calcium is used to prevent or treat negative calcium balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways.
Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively .
| Trade Name | Trimakal |
| Generic | Calcium Lactate |
| Calcium Lactate Other Names | Calcio lactato, Calcium dilactate, Calcium lactate, Hemicalcium L-lactate |
| Weight | 500mg |
| Type | Caplet |
| Formula | C6H10CaO6 |
| Weight | Average: 218.218 Monoisotopic: 218.0103289 |
| Protein binding | No pharmacokinetic data available. |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Minerals in bone formation, Specific mineral preparations |
| Manufacturer | PT Triman |
| Available Country | Indonesia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Trimakal is used for heartburn, calcium supplement, calcium deficiencies.
Trimakal is also used to associated treatment for these conditions: Calcium Deficiency
How Trimakal works
In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways . Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis .
Dosage
Trimakal dosage
19-50 year: 1,000 mg elemental Trimakal per day.
>50 year: 1,200 mg elemental Trimakal per day.
Side Effects
Gl discomfort e.g. nausea, vomiting, constipation; bradycardia, arrhythmias. Dry mouth, increased thirst or increased urination. Mental confusion, milk-alkali syndrome.
Toxicity
The LDLo of calcium lactate pentahydrate following intravenous administration in mouse is 140 mg/kg .
Precaution
Sarcoidosis; history of nephrolithiasis. Avoid IV admin of calcium in patients on cardiac glycosides. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients receiving high doses of vitamin D. Caution when used in patients with history of kidney stones. Patients should be advised to administer vitamin D concurrently to optimise calcium absorption. Pregnancy.
Interaction
May reduce the efficacy of calcium-channel blockers. Concurrent admin of IV calcium salt with cardiac glycosides may lead to serious adverse events. Increased risk of hypercalcaemia when used with thiazide diuretics. May reduce absorption of tetracycline, alendronate, atenolol, iron, quinolone antibiotics, sodium fluoride and zinc.
Food Interaction
No interactions found.Volume of Distribution
The majority of calcium absorbed (99%) is stored in the skeleton and teeth for structural integrity .
Elimination Route
In order to be absorbed, calcium must be in its freely soluble form (Ca2+) or bound to a soluble organic molecule. Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins . The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport .
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
Following oral administration to a human volunteer, 20 to 30% of a dose of lactic acid of up to 3000 mg was excreted via the urine during a period of 14 hours .
Pregnancy & Breastfeeding use
Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Contraindication
Conditions associated with hypercalcaemia and hypercalciuria.
Innovators Monograph
You find simplified version here Trimakal
FAQ
What is Trimakal used for?
Trimakal is used to treat or prevent low blood calcium levels (hypocalcemia) in people who do not get enough calcium from food. Calcium lactate is also used in the treatment of conditions such as osteoporosis, disorders of the parathyroid gland, or certain muscle problems. Indicated for the treatment of Trimakal deficiency states as a therapeutic supplement in pregnancy, lactation, osteoporosis, post-gastrectomy malabsorption, osteomalacia and rickets.
How safe is Trimakal?
According to the Food and Drug Administration (FDA), calcium lactate is generally recognized as safe (GRAS) and may be added to all foods except infant foods and formulas (2).Trimakal is considered a safe source of calcium in calcium supplements.
What are the common side effects of Trimakal?
Common side effects occur: nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, bone/muscle pain, headache, increased thirst/urination, weakness, unusual tiredness.
Is Trimakal safe during pregnancy?
Trimakal should only be given during pregnancy when benefit outweighs risk.
Is Trimakal safe during breastfeeding?
There are no data on the excretion of calcium lactate into human milk. Trimakal is a normal nutritional component of human milk.
Can I drink alcohol with Trimakal?
excessive alcohol interferes with the balance of Trimakal, an essential nutrient for healthy bones. Trimakal balance may be further disrupted by alcohol's ability to interfere with the production of vitamin D, a vitamin essential for Trimakal absorption.
When is the best time to take Trimakal?
Trimakal can make it harder for your body to absorb certain medicines. Trimakal works best if you take it with food.
How many time can I take Trimakal daily?
Trimakal takes 2 to 3 times a day before meals.
How much Trimakal can I take daily?
Trimakal tablets BP should not be taken for long periods without medical advice. Adults including elderly: 1-2 tablets (300-600mg) daily. Pregnant women: (During the third trimester and also during lactation) 3-4 tablets (0.9-1.2g) daily. Children over 3 years: One tablet (300mg) daily.
Can I take Trimakal on an empty stomach?
Take this medication by mouth with food.
Can I take too much Trimakal?
Trimakal is generally considered a safe food preservative. As a supplement, calcium lactate may interact with some medications. Excess intakes of calcium lactate supplements may cause hypercalcemia.
Who should not take Trimakal?
You should not take Trimakal if you have kidney disease, kidney stones; heart problems; a lung disorder called sarcoidosis; a pancreas disorder.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention. Overdose may cause nausea, vomiting, decreased appetite, headache, tiredness, or mood changes.
Can Trimakal be taken long term?
Trimakal may not be safe because it could have an adverse effect on cardiovascular outcomes.
Is Trimakal bad for my heart?
Trimakal may raise the risk of plaque buildup in arteries and heart damage.
Can Trimakal supplements cause kidney stones?
Trimakal supplements are taken, it increases the chances of kidney stones.
Does Trimakal raise blood pressure?
There is evidence that calcium may contribute to elevated blood pressure.
Does Trimakal help me to sleep?
Trimakal with the tryptophan you've eaten to create more melatonin, 3 a sleep-inducing hormone that your body also produces naturally.
Does Trimakal make me grow?
Trimakal is very important for bone growth.
Can I stop taking Trimakal ?
Do not stop taking your calcium channel blocker suddenly as it may bring on an angina attack.
