Trimetasone

Trimetasone Uses, Dosage, Side Effects, Food Interaction and all others data.

Halometasone is a topical corticosteroid with glucocorticoid activity. It exhibits anti-inflammatory and immunosuppressive effects by inhibiting the release of various cytokines.

Triclosan, a chlorinated bisphenol antiseptic, is active against fungi, gram-positive and gram-negative bacteria.

Trade Name Trimetasone
Generic Halometasone + Triclosan
Weight 05%w/w, 1%w/w
Type Cream
Therapeutic Class Other Topical corticosteroids
Manufacturer Geofman Pharmaceuticals
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Trimetasone
Trimetasone

Uses

Acne vulgaris, Corticosteriod-responsive dermatoses

Trimetasone is also used to associated treatment for these conditions: Corticosteroid responsive, Inflammatory DermatosisAcne, Dental Cavity, Dermabrasion, Gingivitis, Oral Infection, Plaque, Dental, Skin Infections, Bacterial, Abrasions, Minor burns, Antibacterial therapy, Antibiotic pre-surgical prophylaxis

How Trimetasone works

Triclosan is a biocidal compound with multiple targets in the cytoplasm and membrane. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to enoyl-acyl carrier protein reductase enzyme (ENR). This complex has increased affinity for NAD+ and forms a ternary complex. This complex is unable to participate in fatty acid synthesis, weakening the cell membrane and causing cell death. Humans do not have an ENR enzyme, and thus are not affected.

Dosage

Trimetasone dosage

Apply on affected areas as directed.

Apply on affected areas as directed.

Side Effects

Contact dermatitis.

Toxicity

Oral LD50, Rat: 3700 mg/kg; Dermal LD50, Rabbit: 9300 mg/kg

Precaution

Risk of systemic absorption when applied to large areas, broken skin or under occlusive dressings.

Elimination Route

A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream. [PMID: 10722890] Triclosan is rapidly absorbed and distributed in the human body (Sandborgh-Englund et al., 2006). Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.

Half Life

The terminal plasma half life of triclosan is 21 h (Sandborgh-Englund et al., 2006).

Elimination Route

In one study, after in vivo topical application of a 64.5mM alcoholic solution of [(3)H]triclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application. [PMID: 10722890]

Pregnancy & Breastfeeding use

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category

Contraindication

Hypersensitivity.

Storage Condition

Should be stored in cool and dry place

Innovators Monograph

You find simplified version here Trimetasone


*** Taking medicines without doctor's advice can cause long-term problems.
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