Triohep Forte
Triohep Forte Uses, Dosage, Side Effects, Food Interaction and all others data.
Silymarin possess hepatoprotective and antioxidant activity. The hepatoprotective effect is due to stimulation of synthesis of structural and functional proteins and phospholipids, as well as acceleration of the regeneration of hepatocytes.
Antioxidant effect is determined by interaction of bioflavones with free radicals in the liver and its detoxication. In such manner the process of peroxidation of the lipids is interupted and further liver destruction is prevented.
Clinically, these effects are manifested by improvement of the signs and symptoms and normalization of the liver variables (serum level of transaminases, gamma-globulins, and bilirubin).
Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and meat. The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections composed by cristalline amino acids.
The diet supplements containing taurine are formulated as a well-tolerated nitrogen source for nutritional support. Administration of diet supplements regulates the level of plasma amino acid concentration, nitrogen balance, weight and serum protein concentration to reach normal values, thus improving the nutritional status.
| Trade Name | Triohep Forte |
| Generic | Taurine + Metadoxine + L-ornithine L-aspartate + Silymarin + S-adenosyl + Myo-inositol / Inositol |
| Weight | 50mg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Amazone Pharmaceuticals Private Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Metadoxine is a medication used to increase the clearance of alcohol in patients with chronic alcohol dependancy.
For the treatment of jaundice, chronic inflammatory liver conditions, i.e. hepatitis, alcoholic liver damage and hepatic cirrhosis. It has anti-oxidant property.
Taurine is an ingredient found in mixture products indicated for nutritional support.
The use of diet supplements containing taurine is indicated for the nutritional support of infants and young pediatric patients requiring total parenteral nutrition via central or peripheral routes. The usage of diet supplements containing taurine prevents nitrogen and weight loss or to treat negative nitrogen balance in pediatric patients where the alimentary tract cannot be done through oral, gastrostomy or jejunostomy administration, there is impaired gastrointestinal absorption or protein requirements are substantially increased.
Triohep Forte is also used to associated treatment for these conditions: Alcohol IntoxicationTotal parenteral nutrition therapy
How Triohep Forte works
The diet supplements containing taurine function by replacing the missing nutriments in the body. Taurine, as a single agent, presents different functions like substrate for formation of bile salts, cell volume regulation, modulation of intracellular calcium, cytoprotection of central nervous system, etc.
Dosage
Triohep Forte dosage
70 mg or 140 mg or 500 mg capsule should be taken 3 times daily as per the instruction of a physician. The medication should be continued until the relief of the symptoms according to the advice of a physician.
Side Effects
A mild laxative effect has occasionally been observed.
Toxicity
The administration of taurine has been correlatefd to significant in the hypothalamus and the modification of neuroendocrine functions. Other than that, taurine administration in regular doses is reported by different articles and institutions to be safe.
Volume of Distribution
The distribution of taurine was studied under the two-compartment model and each one of the compartments gave a range for the volume of distribution of 299-353 ml/kg in compartment 1 and 4608-8374 ml/kg in compartment 2 in mice. Further studies in healthy indivudals gave a volume of distribution that ranged from 19.8 to 40.7 L.
Elimination Route
Oral administration of taurine was studied and it reported dose-dependent values of AUC, Cmax and tmax wherein a dose of 1-30 mg/kg ranged from 89-3452 mcg min/L, 2-15.7 mcg min/ml and 15 min respectively. Further studies in healthy individuals gave an AUC, Cmax and tmax in the range of 116-284.5 mg h/L, 59-112.6 mg/L and 1-2.5 h.
Half Life
Oral administration of taurine in healthy individuals gave a plasma elimination half-life that ranged from 0.7-1.4 h.
Clearance
The clearance rate of orally administered taurine was reported to be dose-dependent wherein a dose of 1 mg/kg it presents a clearance rate of 11.7 ml min/kg, 10 mg/kg generates a clearance rate of 18.7 ml min/kg and a dose of 30 mg/kg reports a clearance rate of 9.4 ml min/kg. Further studies in healthy individuals generate a clearance rate that ranged from 14 to 34.4 L/h.
Elimination Route
Taurine flows and gets distributed in veins and arteries and reports have observed the presence of a significant released of taurine in portally drained viscera, thus suggesting that the main elimination route of taurine is by the gut. This elimination route may be explained by the enterohepatic cycle of taurine.
Pregnancy & Breastfeeding use
No experience is available about the use of Silymarin 70 mg or 140 mg during pregnancy and lactation. Therefore, if needed Silymarin 70 mg or 140 mg should be taken with caution according to the physician’s advice.
Contraindication
No adequate data of investigations are available about the use of this drug in children. Therefore, it should be used in children under 12 years of age with caution under the direct supervision of a physician.
Storage Condition
To be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of reach of children.
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