Trioxsalen

Trioxsalen Uses, Dosage, Side Effects, Food Interaction and all others data.

Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. The photoactivated form produces interstrand linkages in DNA resulting in cell apoptosis. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.

Trioxsalen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue.

Trioxsalen
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Trioxsalen
Availability	Discontinued
Generic	Trioxsalen
Trioxsalen Other Names	Trimethylpsoralen, Trioxisaleno, Trioxsalen, Trioxysalen, Trioxysalene, Trioxysalenum, Trisoralen
Related Drugs	Humira, Cosentyx, methotrexate, Remicade, Stelara, cyclosporine, infliximab
Type	Oral
Formula	C₁₄H₁₂O₃
Weight	Average: 228.2433 Monoisotopic: 228.07864425
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Trioxsalen is a psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.

Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.

How Trioxsalen works

After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Food Interaction

Avoid foods high in furanocoumarins. Eating these foods while you are taking trioxsalen may increase your skin's sensitivity to sunlight. Examples include limes, figs, parsley, parsnips, mustard, carrots, and celery.