Triptofano
Triptofano Uses, Dosage, Side Effects, Food Interaction and all others data.
An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
Triptofano is critical for the production of the body's proteins, enzymes and muscle tissue. It is also essential for the production of niacin, the synthesis of the neurotransmitter serotonin and melatonin. Triptofano supplements can be used as natural relaxants to help relieve insomnia. Triptofano can also reduce anxiety and depression and has been shown to reduce the intensity of migraine headaches. Other promising indications include the relief of chronic pain, reduction of impulsivity or mania and the treatment of obsessive or compulsive disorders. Triptofano also appears to help the immune system and can reduce the risk of cardiac spasms. Triptofano deficiencies may lead to coronary artery spasms. Triptofano is used as an essential nutrient in infant formulas and intravenous feeding. Triptofano is marketed as a prescription drug (Tryptan) for those who do not seem to respond well to conventional antidepressants. It may also be used to treat those afflicted with seasonal affective disorder (a winter-onset depression). Tryptopan serves as the precursor for the synthesis of serotonin (5-hydroxytryptamine, 5-HT) and melatonin (N-acetyl-5-methoxytryptamine).
Trade Name | Triptofano |
Availability | Over the counter |
Generic | Tryptophan |
Tryptophan Other Names | (S)-Tryptophan, L-Tryptophan, Triptofano, Tryptophan, Tryptophane, Tryptophanum |
Related Drugs | turmeric, Ginkgo Biloba, saw palmetto |
Type | |
Formula | C11H12N2O2 |
Weight | Average: 204.2252 Monoisotopic: 204.089877638 |
Groups | Approved, Nutraceutical, Withdrawn |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Triptofano is an amino acid commonly found as a component of total parenteral nutrition.
Triptofano may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.
Triptofano is also used to associated treatment for these conditions: Acute Renal Failure (ARF), Chronic Renal Failure (CRF), Depression, Dialysis therapy, Dietary and Nutritional Therapies, Amino acid supplementation
How Triptofano works
A number of important side reactions occur during the catabolism of tryptophan on the pathway to acetoacetate. The first enzyme of the catabolic pathway is an iron porphyrin oxygenase that opens the indole ring. The latter enzyme is highly inducible, its concentration rising almost 10-fold on a diet high in tryptophan. Kynurenine is the first key branch point intermediate in the pathway. Kynurenine undergoes deamniation in a standard transamination reaction yielding kynurenic acid. Kynurenic acid and metabolites have been shown to act as antiexcitotoxics and anticonvulsives. A second side branch reaction produces anthranilic acid plus alanine. Another equivalent of alanine is produced further along the main catabolic pathway, and it is the production of these alanine residues that allows tryptophan to be classified among the glucogenic and ketogenic amino acids. The second important branch point converts kynurenine into 2-amino-3-carboxymuconic semialdehyde, which has two fates. The main flow of carbon elements from this intermediate is to glutarate. An important side reaction in liver is a transamination and several rearrangements to produce limited amounts of nicotinic acid, which leads to production of a small amount of NAD+ and NADP+.
Toxicity
Oral rat LD50: > 16 gm/kg. Investigated as a tumorigen, mutagen, reproductive effector. Symptoms of overdose include agitation, confusion, diarrhea, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, talking or acting with excitement you cannot control, trembling or shaking, twitching, and vomiting.
Food Interaction
No interactions found.Triptofano Drug Interaction
Major: 5-hydroxytryptophan, duloxetine, sertralineUnknown: amphetamine / dextroamphetamine, naproxen, diphenhydramine, ubiquinone, ubiquinone, omega-3 polyunsaturated fatty acids, levocarnitine, omega-3 polyunsaturated fatty acids, levothyroxine, acetaminophen, valerian, cyanocobalamin, pyridoxine, ascorbic acid, cholecalciferol, alprazolam, cetirizine
Triptofano Disease Interaction
Innovators Monograph
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