Tris(2-hydroxyethyl)amine

Tris(2-hydroxyethyl)amine Uses, Dosage, Side Effects, Food Interaction and all others data.

Tris(2-hydroxyethyl)amine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Tris(2-hydroxyethyl)amine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats . It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products.

Acts as a surfactant or alkalizing agent to aid in emulsification and solubilizing of compounds or in raising the pH of a solution

Trade Name Tris(2-hydroxyethyl)amine
Generic Trolamine
Trolamine Other Names nitrilotriethanol, triethanolamine, tris(2-hydroxyethyl)amine, Trolamine
Type
Formula C6H15NO3
Weight Average: 149.1882
Monoisotopic: 149.105193351
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tris(2-hydroxyethyl)amine
Tris(2-hydroxyethyl)amine

Uses

Tris(2-hydroxyethyl)amine is used as an alkalizing agent, surfactant, and counter-ion in cosmetic and pharmaceutical formulations . It is not considered to be an active pharmacological ingredient and so has no official indication.

Tris(2-hydroxyethyl)amine is also used to associated treatment for these conditions: Soreness, Muscle

How Tris(2-hydroxyethyl)amine works

As an amine, trolamine is capable of accepting a hydrogen to form hydroxide and a conjugate acid. This raises the pH of the solution. As a surfactant, it can lower the interfacial tension in a mixture or solution to prevent separation of emulsions or precipitation of a compound out of solution.

Toxicity

Tris(2-hydroxyethyl)amine produced mild erythema and edema in rabbits with dermally administered doses of 2 g/kg under occlusion . The oral LD50 was found to be 8 g/kg in guinea pigs and 4.19-11.26 g/kg in rats. Repeated oral administration in rats and guinea pigs produced hepatic and renal damage with deaths occurring in rats at doses >0.3 g/kg/day. When inhaled trolamine produced edema and inflammation in rats at doses over 100 mg/m³ after 5 days and at doses over 4.7 mg/m³ after 90 days. There is some evidence of carcinogenicity at high dermal doses (1000 mg/kg/day) in mice. Tris(2-hydroxyethyl)amine is not classified as a carcinogen in humans.

Food Interaction

No interactions found.

Elimination Route

Dermal absorption of trolamine increases with the dose . This has been found to range from 19-28% in rats with doses of 68-276 mg/kg in 190 μL of acetone without occlusion and from 60-80% in mice with doses of 79-1120 mg/kg in the same volume of acetone.

Elimination Route

When orally administered to rats, the 53% of the trolamine dose was found to be excreted in the urine and 20% in the feces . 98% was excreted in the urine with intravenous administration.

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