Tropex 18 mcg Inhalation Capsule
Tropex 18 mcg Inhalation Capsule Uses, Dosage, Side Effects, Food Interaction and all others data.
Tropex 18 mcg Inhalation Capsule is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3-receptors at the smooth muscle leading to bronchodilation. The bronchodilation following inhalation of Tropex 18 mcg Inhalation Capsule is predominantly a site-specific effect.
Tropex 18 mcg Inhalation Capsule is a long acting antimuscarinic that causes bronchodilation. The effects of tiotropium last over 24 hours and there is a wide therapeutic index as overdoses are uncommon even at doses well above the recommended maximum.
| Trade Name | Tropex 18 mcg Inhalation Capsule |
| Availability | Prescription only |
| Generic | Tiotropium |
| Related Drugs | Dupixent, Xolair, ProAir Digihaler, Symbicort, Breo Ellipta, Ventolin, Xopenex, Ventolin HFA, Spiriva |
| Weight | 18 mcg |
| Type | Inhalation Capsule |
| Formula | C19H22NO4S2 |
| Weight | Average: 392.512 Monoisotopic: 392.099024577 |
| Protein binding | Tiotropium is 72% protein bound in plasma. |
| Groups | Approved |
| Therapeutic Class | Anticholinergic bronchodilators |
| Manufacturer | Incepta Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | September 24, 2024 at 5:38 am |
Uses
Tropex 18 mcg Inhalation Capsule is used for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Tropex 18 mcg Inhalation Capsule is also used to associated treatment for these conditions: Asthma, Bronchitis, Bronchoconstriction, Chronic Bronchitis, Chronic Obstructive Airways Disease Exacerbated, Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Respiratory Diseases, Emphysema
How Tropex 18 mcg Inhalation Capsule works
Tropex 18 mcg Inhalation Capsule is an antagonist of muscarinic receptors M1 to M5. Inhibition of the M3 receptor in the smooth muscle of the lungs leads to relaxation of smooth muscle and bronchodilation.
Dosage
Tropex 18 mcg Inhalation Capsule dosage
Adults and adolescents 12 years and older: The recommended dosage of Tropex 18 mcg Inhalation Capsule bromide is the inhalation of 2 puffsonce daily.
Side Effects
The most commonly reported adverse drug reaction was dry mouth. Dry mouth was usually mild and often resolved during continued treatment. Other reactions reported in individual patients and consistent with possible anticholinergic effects included constipation, increased heart rate, blurred vision, glaucoma, urinary difficulty, and urinary retention.
Toxicity
Symptoms of overdose include altered mental status, tremors, abdominal pain, and severe constipation. However, doses of up to 282µg did not lead to systemic anticholinergic effects in a trial of 6 patients. In case of overdose, stop tiotropium and being symptomatic and supportive therapy.
Precaution
As an anticholinergic drug, Tropex 18 mcg Inhalation Capsule may potentially worsen symptoms and signs associated with narrow angle glaucoma, prostatic hyperplasia or bladder-neck obstruction and should be used with caution in patients with any of these conditions. As a predominantly renally excreted drug, patients with moderate to severe renal impairment treated with Tropex 18 mcg Inhalation Capsule should be monitored closely.
Eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema may be signs of acute narrow angle glaucoma. Should any of these signs and symptoms develop, consult a physician immediately. Miotic eye drops alone are not considered to be effective treatment.
Interaction
Tropex 18 mcg Inhalation Capsule has been used concomitantly with other drugs commonly used in COPD without increases in adverse drug reactions. These include sympathomimetic bronchodilators, methylxanthines, and oral and inhaled steroids. However, the co-administration of Tropex 18 mcg Inhalation Capsule with other anticholinergic-containing drugs (e.g., ipratropium) has not been studied and is therefore not recommended.
Food Interaction
- Take with or without food. Food is not expected to interfere with absorption.
Tropex 18 mcg Inhalation Capsule Drug Interaction
Moderate: albuterol / ipratropium, albuterol / ipratropiumUnknown: fluticasone / salmeterol, aspirin, aspirin, omega-3 polyunsaturated fatty acids, fluticasone nasal, furosemide, metoprolol, metoprolol, polyethylene glycol 3350, nitroglycerin, acetaminophen, albuterol, budesonide / formoterol, albuterol, albuterol, cyanocobalamin, ascorbic acid, cholecalciferol
Tropex 18 mcg Inhalation Capsule Disease Interaction
Moderate: angioedema, anticholinergic effects, tachycardia, liver, renal dysfunction
Volume of Distribution
The volume of distribution of tiotropium is 32L/kg.
Elimination Route
33% of an inhaled solution reaches systemic circulation, while oral solutions have a bioavailability of 2-3%. A dry powder for inhalation is 19.5% bioavailable. Tropex 18 mcg Inhalation Capsule metered spray for inhalation reaches a maximum concentration in 5-7 minutes.
Half Life
The terminal half life of tiotropium is 24 hours in patients with COPD and 44 hours in patients with asthma.
Clearance
The total clearance of tiotropium is 880mL/min in healthy subjects receiving 5µg daily. The renal clearance of tiotropium was 669mL/min. Patients 2 This decreased clearance is not associated with increased AUC or Cmax.
Elimination Route
74% of intravenous tiotropium was excreted unchanged in urine. 14% of a dry powder inhalation dose was excreted unchanged in the urine. 24 hour urinary excretion after 21 days of 5µg once daily inhalation in patients with COPD is 18.6% and in patients with asthma is 12.8%.
Pregnancy & Breastfeeding use
Pregnancy Category C. Tropex 18 mcg Inhalation Capsule should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in Labor and Delivery: The safety and effectiveness of Tropex 18 mcg Inhalation Capsule has not been studied during labor and delivery.
Nursing Mothers: Clinical data from nursing women exposed to Tropex 18 mcg Inhalation Capsule are not available. caution should be exercised if administered to a nursing woman.
Contraindication
Tropex 18 mcg Inhalation Capsule is contraindicated in patients with a history of hypersensitivity to atropine or its derivatives, including ipratropium, or to any component of this product.
Special Warning
Pediatric Use: The safety and effectiveness of Tropex 18 mcg Inhalation Capsule in pediatric patients have not been established.
Geriatric use: No adjustment of Tropex 18 mcg Inhalation Capsule dosage in geriatric patients is warranted.
Acute Overdose
High doses of Tropex 18 mcg Inhalation Capsule may lead to anticholinergic signs and symptoms. Acute intoxication by inadvertent oral ingestion of Tropex 18 mcg Inhalation Capsule Bromide unlikely since it is not well-absorbed systemically.
Storage Condition
The inhaler should be stored in a dry, cool place away from direct sunlight and heat. The canister should not be broken, punctured or burnt, even when apparently empty. Keep away from eyes. Keep out of reach of children.
Innovators Monograph
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FAQ
What is Tropex 18 mcg Inhalation Capsule used for?
Tropex 18 mcg Inhalation Capsule is used to prevent wheezing, shortness of breath, coughing, and chest tightness in patients with chronic obstructive pulmonary disease.
How safe is Tropex 18 mcg Inhalation Capsule?
Tropex 18 mcg Inhalation Capsule appears to be efficacious, safe, and well tolerated in patients with asthma and COPD. Dose escalation beyond 5 μg has not been shown to improve spirometric or clinical outcomes, and in asthma, it has been associated with a small increase in adverse events.
What are the common side effects of Tropex 18 mcg Inhalation Capsule?
The common side effects of Tropex 18 mcg Inhalation Capsule are include:
- dry mouth
- constipation
- stomach pain
- vomiting
- indigestion
- muscle pain
- nosebleed
- runny nose
- sneezing
- painful white patches in mouth
How should Tropex 18 mcg Inhalation Capsule be used?
Tropex 18 mcg Inhalation Capsule is usually inhaled once a day in the morning or evening. To help you remember to inhale tiotropium, inhale it around the same time every day.
Is Tropex 18 mcg Inhalation Capsule safe during pregnancy?
The manufacturer makes no recommendation regarding use during pregnancy.The limited data available on use in pregnant women are insufficient to know this drugs risks, including the risk of fetal harm or reproductive effects.
Is Tropex 18 mcg Inhalation Capsule safe during breastfeeding?
The manufacturer makes no recommendation regarding use during lactation.There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.
Can I drink alcohol with Tropex 18 mcg Inhalation Capsule?
Alcohol is known to interact with a number of medications, many people taking this medication are wondering whether it is safe to consume alcohol while on Tropex 18 mcg Inhalation Capsule treatment.
Can I drive after taking Tropex 18 mcg Inhalation Capsule ?
This Tropex 18 mcg Inhalation Capsule can cause dizziness. Use extreme caution when driving a vehicle or using machinery if you take this Tropex 18 mcg Inhalation Capsule.
Can Tropex 18 mcg Inhalation Capsule be used in asthma?
Tropex 18 mcg Inhalation Capsule is only licensed for use in asthma when delivered using the solution for inhalation device, Respimat.
When is the best time to take Tropex 18 mcg Inhalation Capsule?
Tropex 18 mcg Inhalation Capsule is usually inhaled once a day in the morning or evening. To help you remember to inhale Tropex 18 mcg Inhalation Capsule, inhale it around the same time every day.
How long does it take Tropex 18 mcg Inhalation Capsule to work?
Tropex 18 mcg Inhalation Capsule may take 4 to 8 weeks before you get the full benefit of this drug.
How often should I use Tropex 18 mcg Inhalation Capsule?
Tropex 18 mcg Inhalation Capsule is an asthma maintenance medicine taken 1 time each day. You should take 2 puffs 1 time each day,
Does Tropex 18 mcg Inhalation Capsule reduce inflammation?
Tropex 18 mcg Inhalation Capsule exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction.
Does Tropex 18 mcg Inhalation Capsule stop coughing?
Tropex 18 mcg Inhalation Capsule can actually make the cough reflex more sensitive.
What happen If I missed Tropex 18 mcg Inhalation Capsule?
If you miss doses or don’t take the drug on schedule,Your medication may not work as well or may stop working completely.Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once.
What happens If I stop taking Tropex 18 mcg Inhalation Capsule?
If you stop taking the drug or don’t take it at all,You may have worsened shortness of breath or other breathing problems.
What happens if I overdose?
If you take overdose or too much,You could have dangerous levels of the drug in your body. If you think you’ve taken too much of this drug, call your doctor or local poison control center.
