Truxazole

Truxazole Uses, Dosage, Side Effects, Food Interaction and all others data.

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Truxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name Truxazole
Availability Discontinued
Generic Sulfisoxazole
Sulfisoxazole Other Names Sulfadimethylisoxazole, Sulfafurazol, Sulfafurazole, Sulfafurazolum, Sulfaisoxazole, Sulfasoxazole, Sulfisonazole, Sulfisoxasole, Sulfisoxazol, Sulfisoxazole, Sulfofurazole, Sulphadimethylisoxazole, Sulphafurazol, Sulphafurazole, Sulphaisoxazole, Sulphisoxazol, Sulphofurazole
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, dexamethasone, levofloxacin
Type Oral
Formula C11H13N3O3S
Weight Average: 267.304
Monoisotopic: 267.067761987
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Truxazole
Truxazole

Uses

Truxazole is a sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.

For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Truxazole is also used to associated treatment for these conditions: Acute Otitis Media

How Truxazole works

Truxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Toxicity

LD50=6800 mg/kg (Orally in mice)

Food Interaction

No interactions found.

Elimination Route

The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is intact drug, with the remaining as the N4-acetylated metabolite. It is excreted in human milk.

Innovators Monograph

You find simplified version here Truxazole

*** Taking medicines without doctor's advice can cause long-term problems.
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