Tygacil 50 mg/vial IV Infusion

Uses

Tygacil 50 mg/vial IV Infusion is used for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:

Complicated Skin and Skin structure Infections: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes, Enterobacter cloacae, Klebsiella pneumoniae and Bacteroides fragilis.

Complicated Intra-Abdominal Infections: Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.

Community-Acquired Bacterial Pneumonia: Community-acquired bacterial pneumonia caused by Streptococcus pneumoniae (penicillin-susceptible isolates), including cases with concurrent bacteremia, Haemophilus influenzae (beta-lactamase negative isolates), and Legionella pneumophila.

Tygacil 50 mg/vial IV Infusion is also used to associated treatment for these conditions: Bacterial Infections, Community Acquired Pneumonia (CAP), Complicated Intra-Abdominal Infections, Complicated Skin and Skin Structure Infection

How Tygacil 50 mg/vial IV Infusion works

Tygacil 50 mg/vial IV Infusion, a glycylcycline, inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. Tygacil 50 mg/vial IV Infusion carries a glycylamido moiety attached to the 9-position of minocycline. The substitution pattern is not present in any naturally occurring or semisynthetic tetracycline and imparts certain microbiologic properties to tigecycline. Tygacil 50 mg/vial IV Infusion is not affected by the two major tetracycline resistance mechanisms, ribosomal protection and efflux. Accordingly, tigecycline has demonstrated in vitro and in vivo activity against a broad spectrum of bacterial pathogens. There has been no cross resistance observed between tigecycline and other antibiotics. Tygacil 50 mg/vial IV Infusion is not affected by resistance mechanisms such as beta-lactamases (including extended spectrum beta-lactamases), target site modifications, macrolide efflux pumps or enzyme target changes (e.g. gyrase/topoisomerase). In vitro studies have not demonstrated antagonism between tigecycline and other commonly used antibacterial drugs. In general, tigecycline is considered bacteriostatic.

Dosage

Tygacil 50 mg/vial IV Infusion dosage

The duration of therapy should be guided by the severity and site of the infection and the patient's clinical and bacteriological progress. The recommended duration of treatment with Tygacil 50 mg/vial IV Infusion for complicated skin and skin structure infections or for complicated intra-abdominal infections is 5 to 14 days and for community-acquired bacterial pneumonia is 7 to 14 days. The recommended daily dose is as follows:

Adults: The recommended dosage regimen for Tygacil 50 mg/vial IV Infusion is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous (IV) infusions of Tygacil 50 mg/vial IV Infusion should be administered over approximately 30 to 60 minutes every 12 hours.

Pediatric use: Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Geriatric use: No unexpected overall differences in safety or effectiveness were observed between these subjects and younger subjects.

Each vial of Tygacil 50 mg/vial IV Infusion should be reconstituted with 5.3 ml of 0.9% Sodium Chloride Injection to achieve a concentration of 10 mg/ml of Tygacil 50 mg/vial IV Infusion. The vial should be gently swirled until the drug dissolves. Withdraw 5 ml of the reconstituted solution from the vial and add to a 100 ml intravenous bag of 0.9% Sodium Chloride or 5% Dextrose for infusion (for a 100 mg dose, reconstitute two vials; for a 50 mg dose, reconstitute one vial). The maximum concentration of IV solution should be 1 mg/ml. If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of Tygacil 50 mg/vial IV Infusion with either 0.9% Sodium Chloride Injection or 5% Dextrose Injection. Tygacil 50 mg/vial IV Infusion is compatible with the following IV fluid: 0.9% Sodium Chloride Injection, 5% Dextrose Injection, Lactated Ringer’s Injection.

Side Effects

The most common treatment-emergent adverse events are nausea and vomiting which generally occurre during the first 1-2 days of therapy.

The following drug-related adverse events are reported infrequently in patients receiving Tygacil 50 mg/vial IV Infusion: Injection site inflammation & pain, septic shock, allergic reaction, chills, thrombophlebitis, bradycardia, tachycardia, vasodilatation, anorexia, dry mouth, hypoglycemia, hyponatremia, prolonged prothrombin time, eosinophilia, thrombocytopenia, vaginal moniliasis, vaginitis, leukorrhea.

Toxicity

Since glycylcyclines are similar to tetracyclines, they share many of the same side effects and contraindications as tetracyclines. These side effects may include nausea/vomiting, headache, photosensitivity, discoloration of growing teeth, and fetal damage.

Precaution

Tygacil 50 mg/vial IV Infusion is structurally similar to Tetracycline-class antibiotics and should be administered with caution in patients with known hypersensitivity to Tetracycline-class antibiotics

Interaction

Drug interaction of Tygacil 50 mg/vial IV Infusion with Digoxin and Warfarin is observed.

Food Interaction

Tygacil 50 mg/vial IV Infusion Drug Interaction

Unknown: aspirin, epinephrine, albumin human, spironolactone, RHO Immunoglobulin , calcium / vitamin d, sulfamethoxazole / trimethoprim, albuterol / ipratropium, meperidine, metronidazole, heparin, clonazepam, micafungin, acetaminophen, procaine penicillin, penicillin v potassium, phenytoin, pantoprazole, valproic acid, cyanocobalamin

Tygacil 50 mg/vial IV Infusion Disease Interaction

Major: colitisModerate: liver disease

Half Life

27-43 hours

Pregnancy & Breastfeeding use

Pregnancy: Tygacil 50 mg/vial IV Infusion should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: Caution should be exercised when Tygacil 50 mg/vial IV Infusion is administered to a nursing woman.

Contraindication

Tygacil 50 mg/vial IV Infusion is contraindicated for use in patients who have known hypersensitivity to Tygacil 50 mg/vial IV Infusion.

Acute Overdose

No specific information is available on the treatment of overdosage with Tygacil 50 mg/vial IV Infusion. Intravenous administration of Tygacil 50 mg/vial IV Infusion at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting.

Storage Condition

Prior to reconstitution, Tygacil 50 mg/vial IV Infusion should be stored at 20°C to 25°C. Once reconstituted, Tygacil 50 mg/vial IV Infusion may be stored at room temperature for up to 24 hours (up to 6 hours in the vial and the remaining time in the intravenous bag). Reconstituted solution may be stored refrigerated at 2°C to 8°C for up to 48 hours following immediate transfer of reconstituted solution into the intravenous bag.

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