Tyloxapol Uses, Dosage, Side Effects and more
Tyloxapol is a non-ionic detergent often used as a surfactant.
It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Trade Name | Tyloxapol |
Generic | Tyloxapol |
Tyloxapol Other Names | Tyloxapol |
Type | |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | January 7, 2025 at 1:49 am |
Uses
Tyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
How Tyloxapol works
Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.
Toxicity
Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat.