Typhoid conjugate vaccine

Typhoid conjugate vaccine Uses, Dosage, Side Effects, Food Interaction and all others data.

Typhoid conjugate vaccine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Typhoid conjugate vaccine
Generic	Typhoid conjugate vaccine
Type
Therapeutic Class	Vaccines, Anti-sera & Immunoglobulin
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Uses

Typhoid Conjugate Vaccine is indicated for active immunization against infection caused by Salmonella typhi in infants, children, adolescents and adults aged >6 months to <45 years.

Dosage

Typhoid conjugate vaccine dosage

A single 0.5 mL dose of the vaccine should be administered intramuscularly in the deltoid muscle of upper arm if muscle mass is adequate for children 2 years and above, adolescents and adults. For infants and toddlers aged >6 months to <2 years of age, the vaccine should be administered intramuscularly in the vastus lateralis muscle on anterolateral aspect of thigh. This vaccine should not be injected into the gluteal area or in any areas where there may be a nerve trunk.

Side Effects

The most frequently reported local adverse events after administration of Biological E's Typhoid Vi Conjugate vaccine were Injection Site Pain (4.50%), Injection Site erythema (0.64%) and Injection site Swelling (0.32%). These usually occurred within first 48 hours and disappeared within 2-3 days. The most frequently reported systemic adverse events were Pyrexia (2.25%), Vomiting (0.96%), Headache (0.64%), Fatigue (0.64%), Arthralgia (0.32%) and Rash (0.32%). No vaccine-related serious adverse events (SAEs) were reported in the clinical trial.

Precaution

Do not administer intravenously, intradermally or subcutaneously.Typhoid conjugate vaccine protects against typhoid fever caused by Salmonella typhi. Protection is not conferred against Salmonella paratyphi and other non typhoidal Salmonellae.Adrenaline (epinephrine) injection, 1:1000 (1 mg/mL) must be immediately available in case of an acute anaphylactic reaction or any allergic reaction occurs due to any component of the vaccine. The vaccinee should remain under medical supervision for not less than 30 minutes after vaccination. Like all other vaccines, supervision and appropriate medical treatment should always be available to treat any anaphylactic reactions following immunization.

Interaction

As on date there is no clinical data on co-administration of this vaccine. Hence, Biological E's Typhoid Vi conjugate vaccine should not be mixed with any other vaccine or medicinal product. For concomitant administration use different injection sites and separate syringes.

Pregnancy & Breastfeeding use

Safety and effectiveness have not been established in pregnant women and in nursing mothers. It is not known whether the vaccine is excreted in human milk.