U40
U40 Uses, Dosage, Side Effects, Food Interaction and all others data.
U40 is an osmotic diuretic similar to mannitol but more irritant. It induces diuresis by increasing osmotic pressure of the glomerular filtrate and increasing excretion of sodium, potassium and chloride ions. Its osmotic effect also draws water from cells e.g. brain, CSF and anterior chamber of the eye, thereby decreasing intracranial or intraocular pressure. Unlike mannitol, urea penetrates the eye and causes a rebound increase in intraocular pressure if the plasma concentration of the drug is less than that in the vitreous humour. Applied topically, urea promotes hydration of keratin and mild keratolysis in dry skin. It increases water uptake by the stratum corneum and has an antipruritic effect.
As a humectant, urea draws water into the striatum corneum.
| Trade Name | U40 |
| Availability | Rx and/or OTC |
| Generic | Urea |
| Urea Other Names | Carbamide, Carbonyldiamide, Harnstoff, Karbamid, Urea, Urée |
| Related Drugs | tolvaptan, Samsca, sodium acetate, ure-Na |
| Type | Aerosol, Foam, Topical Cream, Topical Emulsion, Topical Foam, Topical Gel, Topical Kit, Topical Lotion, Topical Ointment, Topical Paste, Topical Shampoo, Topical Solution, Topical Stick, Topical Suspension |
| Formula | CH4N2O |
| Weight | Average: 60.0553 Monoisotopic: 60.03236276 |
| Groups | Approved, Investigational |
| Therapeutic Class | Topical urea preparations |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
U40 25% cream is used for the treatment of dry, cracked skin and hyperkeratosis on the soles of the feet including the heels. Suitable for general and diabetic foot care.
U40 is also used to associated treatment for these conditions: Dermatitis, Dermatitis, Contact, Dermatitis, Eczematous, Dry Eyes, Dry Skin, Dry Skin; Eczema, Eczema, Dyshidrotic, Eye pruritus, Helicobacter Pylori Infection, Insect Bites, Lichen Planus (LP), Neurodermatitis, Nummular Dermatitis, Psoriasis, Seborrheic Dermatitis, Sunburn, Allergic skin manifestations, Anal eczema, Calluses, Moisturizing
Dosage
U40 dosage
Apply a small amount twice daily to the skin after washing or bathing.
In extreme cases, before bed you may choose to cover the feet with plastic wrap and then put socks over the plastic wrap to increase the hydration rate.
Recommended for use on adults and children over 12 years.
After use, wear sandals or slippers to avoid staining carpets.
Side Effects
May irritate inflamed skin or exudative lesions. Transient stinging may occur in deep cracks. Discontinue use if local irritation or rash occurs during use.
Food Interaction
No interactions found.U40 Drug Interaction
Moderate: glycerin, escitalopramUnknown: aspirin, aspirin, sulfamethoxazole / trimethoprim, ubiquinone, copper gluconate, meperidine, omega-3 polyunsaturated fatty acids, pregabalin, metoprolol, acetaminophen / hydrocodone, bioflavonoids, montelukast, levothyroxine, cyanocobalamin, ascorbic acid, ergocalciferol, cholecalciferol, cetirizine
U40 Disease Interaction
Pregnancy & Breastfeeding use
U40 cream can be used during pregnancy and lactation.
Contraindication
For use only on the soles of the feet and heels unless otherwise directed by the prescriber. Pregnant women should consult their Healthcare Professional before use. For External Use Only. Avoid contact with eyes. Keep out of reach of children. Always replace cap after use. Do not use if tube seal is broken or appears tampered with.
Storage Condition
Store between 10° – 30° C in a dry place. Keep lid tightly closed.
Innovators Monograph
You find simplified version here U40
FAQ
What is U40 used for?
U40 is used to treat dry skin conditions (e.g., eczema, psoriasis, corns, callus) and some nail problems (e.g., ingrown nails). It may also be used to help remove dead tissue in some wounds to help wound healing.
How safe urea is?
U40 can be toxic if fed at too high a level so it's important not to overfeed and mixing thoroughly is vital. The level of U40 required is low, a maximum level of 0.7% of the overall feed dry matter is advised.
What are the common side effect of U40?
Common side effects of U40 include:
- Local irritation (burning, itching, redness)
- Temporary stinging.
- Rash.
What does U40 do to the body?
U40 is known as a keratolytic agent. This means it breaks down the protein keratin in the outer layer of your skin. U40 can help reduce dead skin buildup and get rid of flaking or scaling skin.
Is U40 safe during pregnancy?
It is not known whether urea topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
Is U40 safe during breastfeeding?
It is not known whether urea topical passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.
Can I drink alcohol with U40?
The presence of U40 decreases the hydrophobic effect of a monovalent alcohol, strongly at low temperatures, to a lesser degree at high temperatures . Consequently, urea hinders the interhydrophobic interactions by affecting the water molecules.
What does U40 do in the kidney?
The urea travels from your liver to your kidneys through your bloodstream.Healthy kidneys filter U40 and remove other waste products from your blood.
How does U40 help skin?
U40 providing hydration to smooth your skin's texture, and by helping to reduce the buildup of dead skin cells.
Can I use U40 on hands?
Wash your hands before and after use.Do not take U40 cream and ointment by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
Is U40 in skincare urine?
The U40 used in skin care products is made synthetically in a lab, but U40 is also naturally found on your skin and is excreted in urine.
Is U40 cream made from urine?
The U40 used in skin care products is made synthetically in a lab, but U40 is also naturally found on your skin and is excreted in urine.
How often should I use U40?
U40 usually taken 1 to 3 times a day or as directed by your doctor. Rub in well until absorbed.
What are the advantages of U40 fertilizer?
U40 has several advantages, including cost per pound of nitrogen, higher nutrient density and good handling and storage properties.
How does U40 cream work?
U40 can breaks down the protein keratin in the outer layer of your skin. This action can help reduce dead skin buildup and get rid of flaking or scaling skin.
How long does U40 fertilizer take to work?
This can occur in two to four days and happens more quickly on high pH soils.
Is U40 a toxin?
U40 exerts both direct and indirect toxic effects on several organs in the body.
What role U40 plays in liver?
Two of these are the control of amino acid concentration and detoxification.U40 is produced in the liver and is a metabolite of amino acids. Ammonium ions are formed in the breakdown of amino acids.
