Uliv Tablet 150 mg

Uliv Tablet 150 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Uliv Tablet 150 mg is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Uliv Tablet 150 mg is achieved through a decrease in secretion of cholesterol in bile. Uliv Tablet 150 mg achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.

Therefore, alters bile composition from supersaturated to unsaturated. Uliv Tablet 150 mg also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Uliv Tablet 150 mg improves cholestatic liver diseases by-

Protecting cholangiocytes against cytotoxicity of hydrophobic bile acidsStimulating hepatobilliary secretionProtecting hepatocytes against bile acid-induced apoptosisUliv Tablet 150 mg is completely absorbed in the upper intestine. Time to peak serum concentration varies from 30 to 150 minutes. The rate of absorption ranges from 60-80%. After absorption Uliv Tablet 150 mg enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Uliv Tablet 150 mg appear in the circulation and very small amounts are excreted into urine. The biologic half life of Uliv Tablet 150 mg ranges from 3.5-5.8 days.

Ursodiol (commonly known as ursodeoxycholic acid) is a product of metabolism of bacteria in the intestine. It is considered a secondary bile acid. The other type of bile acid, primary bile acids, are produced hepatically and subsequently stored in the gallbladder. When primary bile acids are secreted into the large intestine, they can be broken down into secondary bile acids by bacteria present in the intestine. Both types of bile acids assist in the metabolism of dietary fat. Ursodeoxycholic acid regulates cholesterol levels by slowing the rate at which the intestine is able to absorb cholesterol and also acts to break down micelles, which contain cholesterol. Because of this property, ursodeoxycholic acid is used to treat gall stones non-surgically.

Trade Name Uliv Tablet 150 mg
Generic Ursodeoxycholic Acid
Ursodeoxycholic Acid Other Names Acide ursodesoxycholique, Acido ursodeossicolico, Acido ursodeoxicolico, Acidum ursodeoxycholicum, UDCA, Ursodeoxycholate, Ursodeoxycholic acid, Ursodiol
Weight 150 mg
Type Tablet
Formula C24H40O4
Weight Average: 392.572
Monoisotopic: 392.292659768
Groups Approved, Investigational
Therapeutic Class Anti-gallstones drugs: Bile Acids
Manufacturer ACME Laboratories Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Uliv Tablet 150 mg
Uliv Tablet 150 mg

Uses

Uliv Tablet 150 mg is used for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

Ursodeoxycholic acid is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones. The cholesterol saturation of bile is reduced by Ursodeoxycholic acid, allowing gradual solubilization of cholesterol gallstones. Cholesterol of secretion into bile is reduced and bile acid secretion rate is increased during Ursodeoxycholic acid treatment without a reduction in phospholipids.

Uliv Tablet 150 mg is also used to associated treatment for these conditions: Primary Biliary Cholangitis, Gallstone formation

How Uliv Tablet 150 mg works

Ursodeoxycholic acid reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells. The main mechanism if anticholelithic. Although the exact process of ursodiol's anticholelithic action is not completely understood, it is thought that the drug is concentrated in bile and decreases biliary cholesterol by suppressing hepatic synthesis and secretion of cholesterol and by inhibiting its intestinal absorption. The reduced cholesterol saturation permits the gradual solubilization of cholesterol from gallstones, resulting in their eventual dissolution.

Dosage

Uliv Tablet 150 mg dosage

Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses

PBC: 10-15 mg/kg/day in 2-4 divided doses

Acute Viral Hepatitis: 600 mg/day

Alcoholic Fatty Liver: 300 mg/day

PSC: 25-30 mg/kg/day

NASH: 13-15 mg/kg/day

Side Effects

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.

Toxicity

Neither accidental nor intentional overdosing with ursodeoxycholic acid has been reported. Doses of ursodeoxycholic acid in the range of 16-20 mg/kg/day have been tolerated for 6-37 months without symptoms by 7 patients. The LD50 for ursodeoxycholic acid in rats is over 5000 mg/kg given over 7-10 days and over 7500 mg/kg for mice. The most likely manifestation of severe overdose with ursodeoxycholic acid would probably be diarrhea, which should be treated symptomatically.

Precaution

It should be used cautiously in those with liver disease.

Interaction

Uliv Tablet 150 mg should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.

Food Interaction

  • Take with food.

Elimination Route

Only small quantities of ursodiol appear in the systemic circulation and very small amounts are excreted into urine. Eighty percent of lithocholic acid formed in the small bowel is excreted in the feces, but the 20% that is absorbed is sulfated at the 3-hydroxyl group in the liver to relatively insoluble lithocholyl conjugates which are excreted into bile and lost in feces.

Pregnancy & Breastfeeding use

Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.

Contraindication

Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.

Storage Condition

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.

Innovators Monograph

You find simplified version here Uliv Tablet 150 mg

FAQ

What is Uliv Tablet 150 mg used for?

Uliv Tablet 150 mg usued to prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. It has a role as a human metabolite and a mouse metabolite.

How safe is Uliv Tablet 150 mg?

Uliv Tablet 150 mg appears to be a safe and effective alternative to surgery in selected patients with gallstones. Uliv Tablet 150 mg use to safe if you are not allergic to it.

What are the common side effects Uliv Tablet 150 mg ?

Common side effects of Uliv Tablet 150 mg are include:

Stomach upset, nausea, diarrhea, dizziness, back pain, hair loss, or cough may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What does Uliv Tablet 150 mg do to my body?

Uliv Tablet 150 mg works by reducing the amount of cholesterol released by your liver and by slowly dispersing the cholesterol.

How long should Uliv Tablet 150 mg be taken?

For the first 3 months of treatment Uliv Tablet 150 mg should be taken divided over the day. The use of Uliv Tablet 150 mg capsules in PBC may be continued indefinitely.

Is Uliv Tablet 150 mg safe during pregnancy?

Uliv Tablet 150 mg is effective and safe in patients with intrahepatic cholestasis of pregnancy of early onset, attenuating pruritus and correcting some biochemical abnormalities in the mothers.

Is Uliv Tablet 150 mg safe during breastfeeding?

Because of the low levels of Uliv Tablet 150 mg in breastmilk, amounts ingested by the infant are small and are not expected to cause any adverse effects in breastfed infants.No special precautions are required.

Can I drink alcohol with Uliv Tablet 150 mg?

Avoid alcoholic drinks when taking Uliv Tablet 150 mg. Alcohol may change how the drug is released in your body. This may cause more side effects or cause the drug to become less effective

When is the best time to take Uliv Tablet 150 mg?

Uliv Tablet 150 mg is usually taken once daily at bedtime. Sometimes your doctor may suggest you take two doses each day, in which case, take your last dose of the day at bedtime. If you are taking Uliv Tablet 150 mg for primary biliary cholangitis, it is likely that you will be asked to take 2-4 doses daily.

How long does it take for Uliv Tablet 150 mg to work?

Uliv Tablet 150 mg take for up to two years for the treatment of gallstones. Once the gallstones have dissolved, your doctor may continue your treatment for three to four months to ensure that they have completely cleared up.

Does Uliv Tablet 150 mg cause weight gain?

People gain an average of 2.3kg during the first year of taking Uliv Tablet 150 mg, although there's not usually any more weight gain after this.

Can Uliv Tablet 150 mg cause kidney problems?

Uliv Tablet 150 mg may reduces albuminuria and prevent progression of kidney damage.

When should I take Uliv Tablet 150 mg?

It is best to take Uliv Tablet 150 mg with meals, unless otherwise directed by your doctor. Take this medicine for the full time of treatment, even if you begin to feel better.

Is Uliv Tablet 150 mg a steroid?

Uliv Tablet 150 mg  is a steroid bile acid approved for primary biliary cirrhosis.

Will Uliv Tablet 150 mg affect my fertility ?

Uliv Tablet 150 mg could help achieve conception in infertile women with primary biliary cirrhosis.

Will Uliv Tablet 150 mg affect my contraception?

Uliv Tablet 150 mg does not affect ethinylestradiol bioavailability in women taking oral contraceptives.

What are the indications of Uliv Tablet 150 mg?

Uliv Tablet 150 mg is indicated in the treatment of primary biliary cirrhosis (PBC) and for the dissolution of radiolucent gallstones in patients with a functioning gall bladder. 

Where does Uliv Tablet 150 mg come from?

Produced in humans and most other species from metabolism by intestinal bacteria.

Who should not take Uliv Tablet 150 mg?

You should not use if you are allergic to it or have an obstruction in your liver or gallbladder.

What happens if I stop taking Uliv Tablet 150 mg?

If you stop taking Uliv Tablet 150 mg too soon, the gallstones may not dissolve as fast or may not dissolve at all. It is thought that body weight and the kind of diet the patient follows may affect how fast the stones dissolve and whether new stones will form.

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*** Taking medicines without doctor's advice can cause long-term problems.
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