Ultravist 370
Ultravist 370 Uses, Dosage, Side Effects, Food Interaction and all others data.
Ultravist 370 is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.
Available as the FDA-approved product Ultravist, iopromide is used in radiographic studies such as intra-arterial digital subtraction angiography (IA-DSA), cerebral and peripheral arteriography, peripheral venography, excretory urography, brain computer tomography (CT), coronary arteriography, left ventriculography, visceral angiography, and aortography.
Trade Name | Ultravist 370 |
Availability | Prescription only |
Generic | Iopromide |
Iopromide Other Names | Iopromida, Iopromide |
Related Drugs | iohexol, barium sulfate, Omnipaque 350, Omnipaque 300, ioversol, Ultravist, iodixanol, Visipaque, Omnipaque 240, DaTscan |
Weight | 0.769g/ml |
Type | Injection |
Formula | C18H24I3N3O8 |
Weight | Average: 791.1119 Monoisotopic: 790.869745019 |
Protein binding | Plasma protein binding of iopromide is 1%. |
Groups | Approved |
Therapeutic Class | |
Manufacturer | Bayer Schering Pharma Ag |
Available Country | Germany, Nigeria |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ultravist 370 is an X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests.
Ultravist 370, as the product Iovist, is indicated for use as an X-ray contrast agent in the following procedures: Intra-arterial digital subtraction angiography (IA-DSA) (150 mg I/mL) Cerebral arteriography and peripheral arteriography (300 mg I/mL) Coronary arteriography and left ventriculography, visceral angiography and aortography (370 mg I/mL) Peripheral venography (240 mg I/mL) Excretory urography (300 mg I/mL) Contrast computed tomography (CT) imaging of head and body (300 mg I/mL and 370 mg I/mL)
Ultravist 370 is also used to associated treatment for these conditions: Neoplastic lesion, Non-neoplastic lesion
How Ultravist 370 works
Ultravist 370 is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.
Toxicity
Most common adverse reactions (>1%) are headache, nausea, injection site and infusion site reactions, vasodilatation, vomiting, back pain, urinary urgency, chest pain, pain, dysgeusia, and abnormal vision. Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema.
Food Interaction
No interactions found.Ultravist 370 Drug Interaction
Unknown: aspirin, aspirin, charcoal, charcoal, epinephrine, epinephrine, amoxicillin, amoxicillin, heparin, heparin, sodium iodide, sodium iodide, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, pyridoxine, pyridoxine, phytonadione, phytonadione
Ultravist 370 Disease Interaction
Volume of Distribution
16 L
Elimination Route
Following administration, the degree of contrast enhancement is directly related to the iodine content in the administered dose; peak iodine plasma levels occur immediately following rapid intravenous injection. Iodine plasma levels fall rapidly within 5 to 10 minutes, which can be accounted for by the dilution in the vascular and extravascular fluid compartments. Contrast enhancement appears to be greatest immediately after bolus injections (15 seconds to 120 seconds). Thus, greatest enhancement may be detected by a series of consecutive two-to-three second scans performed within 30 to 90 seconds after injection (that is, dynamic computed tomographic imaging). Injection may be visualized in the renal parenchyma within 30–60 seconds following rapid intravenous injection. Opacification of the calyces and pelves in patients with normal renal function becomes apparent within 1–3 minutes, with optimum contrast occurring within 5–15 minutes.
Half Life
After intravenous administration to healthy young volunteers, plasma iopromide concentration time profile shows an initial distribution phase with a half-life of 0.24 hour; a main elimination phase with a half-life of 2 hours; and a terminal elimination phase with a half-life of 6.2 hours.
Clearance
The mean total and renal clearances are 107 mL/min and 104 mL/min, respectively.
Elimination Route
The amounts excreted unchanged in urine represent 97% of the dose in young healthy subjects. Only 2% of the dose is recovered in the feces. Similar recoveries in urine and feces are observed in middle-aged and elderly patients. This finding suggests that, compared to the renal route, biliary and/or gastrointestinal excretion is not important for iopromide. During the slower terminal phase only 3% of the dose is eliminated; 97% of the dose is disposed of during the earlier phases, the largest part of which occurs during the main elimination phase.
Innovators Monograph
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