Urate Oxidase Uses, Dosage, Side Effects and more

Urate Oxidase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.

Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.

Trade Name	Urate Oxidase
Availability	Prescription only
Generic	Rasburicase
Rasburicase Other Names	Rasburicasa, Rasburicase, Urate oxidase
Related Drugs	allopurinol, sodium bicarbonate, Zyloprim, Elitek, Aloprim
Type
Formula	C1521H2381N417O461S7
Weight	34109.5 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	January 7, 2025 at 1:49 am

Uses

Urate Oxidase is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.

For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)

Urate Oxidase is also used to associated treatment for these conditions: Hyperuricemia

How Urate Oxidase works

Urate Oxidase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).

Food Interaction

No interactions found.

Drug Interaction

Unknown: aripiprazole, papain/urea topical, charcoal, doxorubicin, oxymetazoline nasal, antihemophilic factor/von willebrand factor, darbepoetin alfa, azithromycin, sulfamethoxazole / trimethoprim, meperidine, fluorouracil topical, heparin, levocarnitine, phenazopyridine, vitamin a topical, bioflavonoids, sotalol, cyanocobalamin, cholecalciferol, ondansetron

Disease Interaction

Major: G6PD deficiency

Volume of Distribution

• 110 to 127 mL/kg [pediatric patients]
• 75.8 to 138 mL/kg [adult patients]

Half Life

18 hours

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