Urate Oxidase

Urate Oxidase Uses, Dosage, Side Effects, Food Interaction and all others data.

Urate Oxidase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.

Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.

Trade Name Urate Oxidase
Availability Prescription only
Generic Rasburicase
Rasburicase Other Names Rasburicasa, Rasburicase, Urate oxidase
Related Drugs allopurinol, sodium bicarbonate, Zyloprim, Elitek, Aloprim
Type
Formula C1521H2381N417O461S7
Weight 34109.5 Da
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Urate Oxidase
Urate Oxidase

Uses

Urate Oxidase is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.

For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)

Urate Oxidase is also used to associated treatment for these conditions: Hyperuricemia

How Urate Oxidase works

Urate Oxidase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).

Food Interaction

No interactions found.

Urate Oxidase Disease Interaction

Major: G6PD deficiency

Volume of Distribution

  • 110 to 127 mL/kg [pediatric patients]
  • 75.8 to 138 mL/kg [adult patients]

Half Life

18 hours

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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