Urate Oxidase
Urate Oxidase Uses, Dosage, Side Effects, Food Interaction and all others data.
Urate Oxidase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.
Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.
Trade Name | Urate Oxidase |
Availability | Prescription only |
Generic | Rasburicase |
Rasburicase Other Names | Rasburicasa, Rasburicase, Urate oxidase |
Related Drugs | allopurinol, sodium bicarbonate, Zyloprim, Elitek, Aloprim |
Type | |
Formula | C1521H2381N417O461S7 |
Weight | 34109.5 Da |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Urate Oxidase is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)
Urate Oxidase is also used to associated treatment for these conditions: Hyperuricemia
How Urate Oxidase works
Urate Oxidase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).
Food Interaction
No interactions found.Urate Oxidase Drug Interaction
Unknown: aripiprazole, papain/urea topical, charcoal, doxorubicin, oxymetazoline nasal, antihemophilic factor/von willebrand factor, darbepoetin alfa, azithromycin, sulfamethoxazole / trimethoprim, meperidine, fluorouracil topical, heparin, levocarnitine, phenazopyridine, vitamin a topical, bioflavonoids, sotalol, cyanocobalamin, cholecalciferol, ondansetron
Urate Oxidase Disease Interaction
Volume of Distribution
- 110 to 127 mL/kg [pediatric patients]
- 75.8 to 138 mL/kg [adult patients]
Half Life
18 hours
Innovators Monograph
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