Uritro Oral Suspension 25 mg/5 ml
Uritro Oral Suspension 25 mg/5 ml Uses, Dosage, Side Effects, Food Interaction and all others data.
Uritro Oral Suspension 25 mg/5 ml interferes with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A. It is bactericidal to most gram-positive and gram-negative urinary tract pathogens.
Uritro Oral Suspension 25 mg/5 ml interferes with vital processes in bacteria, which leads to their death. Uritro Oral Suspension 25 mg/5 ml rapidly reaches therapeutic concentrations in the urine and is also cleared rapidly.
| Trade Name | Uritro Oral Suspension 25 mg/5 ml |
| Availability | Prescription only |
| Generic | Nitrofurantoin |
| Nitrofurantoin Other Names | 5-Nitrofurantoin, Nitrofurantoin, Nitrofurantoin macrocrystal, Nitrofurantoin macrocrystalline, nitrofurantoina, nitrofurantoine, nitrofurantoinum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, ceftriaxone, levofloxacin, Augmentin, Keflex, sulfamethoxazole / trimethoprim, Bactrim |
| Weight | 25 mg/5 ml |
| Type | Oral Suspension |
| Formula | C8H6N4O5 |
| Weight | Average: 238.159 Monoisotopic: 238.033819309 |
| Protein binding | Nitrofurantoin could be up to 90% protein bound in plasma. |
| Groups | Approved, Vet approved |
| Therapeutic Class | Systemic Urinary Anti- infective |
| Manufacturer | Team Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Uritro Oral Suspension 25 mg/5 ml is specifically used for the treatment & prophylaxis of urinary tract infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Uritro Oral Suspension 25 mg/5 ml is also used to associated treatment for these conditions: Acute Cystitis, Urinary Tract Infection
How Uritro Oral Suspension 25 mg/5 ml works
Uritro Oral Suspension 25 mg/5 ml is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.
Dosage
Uritro Oral Suspension 25 mg/5 ml dosage
Tablet:
- Adults: 50-100 mg four times a day - the lower dosage level is recommended for uncomplicated urinary tract infections.
- Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
- For long-term suppressive therapy in adults:a reduction of dosage to 50-100 mg at bedtime may be adequate. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
SR Capsule:
- Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days.
- Genito-urinary surgical prophylaxis: One capsule twice daily on day of procedure and for next 3 days.
Suspension:
Children: 5-7 mg/kg/day in four divided doses (contraindicated under 1 month of age). The average dose of Uritro Oral Suspension 25 mg/5 mlsuspension for pediatric patients can be calculated as follows:-
- For 7 to 11 kg Body Weight patient: ½ (2.5 ml) teaspoonfuls (4 times daily)
- For 12 to 21 kg Body Weight patient: 1 (5 ml) teaspoonfuls (4 times daily)
- For 22 to 30 kg Body Weight patient: 1 ½ (7.5 ml) teaspoonfuls (4 times daily)
- For 31 to 41 kg Body Weight patient: 2 (10 ml) teaspoonfuls (4 times daily)
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
Uritro Oral Suspension 25 mg/5 ml should be taken with food.
Side Effects
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness, drowsiness
Toxicity
Symptoms of overdose include vomiting. In case of overdose, induce vomiting if it has not already occurred and increase fluid intake to promote urination. In extreme cases, nitrofurantoin can be removed from circulation by dialysis.
Precaution
If acute, sub-acute, or chronic pulmonary reactions occur, Uritro Oral Suspension 25 mg/5 ml should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Uritro Oral Suspension 25 mg/5 ml
Interaction
Reduced excretion with probenecid or sulfinpyrazone. Absorption reduced by magnesium trisilicate. Antagonistic effects with quinolone antibacterials. Reduced effects with carbonic anhydrase inhibitors or urinary alkalinisers.
Food Interaction
- Take with food. Food decreases irritation and increases bioavailability.
Uritro Oral Suspension 25 mg/5 ml Drug Interaction
Moderate: bifidobacterium infantis / lactobacillus acidophilusUnknown: aspirin, diphenhydramine, ubiquinone, duloxetine, apixaban, omega-3 polyunsaturated fatty acids, fluticasone nasal, pregabalin, metoprolol, polyethylene glycol 3350, mirabegron, acetaminophen / hydrocodone, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, alprazolam, cetirizine
Uritro Oral Suspension 25 mg/5 ml Disease Interaction
Major: colitis, G-6-PD deficiency, hepatotoxicity, renal dysfunctionModerate: peripheral neuropathy, respiratory
Volume of Distribution
Data regarding the volume of distribution in humans is scarce but it has been reported as 0.46L/kg in dogs.
Elimination Route
Uritro Oral Suspension 25 mg/5 ml reaches a Cmax of 0.875-0.963mg/L with an AUC of 2.21-2.42mg*h/L. It is 38.8-44.3% bioavailable. Taking nitrofurantoin with food increases the absorption and duration of therapeutic concentrations in the urine.
Half Life
The half life of nitrofurantoin is 0.72-0.78h.
Clearance
The clearance of nitrofurantoin is 16.7-19.4L/h.
Elimination Route
27-50% of an oral dose is excreted in the urine as unchanged nitrofurantoin. 90% of the total dose is eliminated in the urine.
Pregnancy & Breastfeeding use
Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.
Uritro Oral Suspension 25 mg/5 ml has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Uritro Oral Suspension 25 mg/5 ml in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Contraindication
Anuria, oliguria, or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Uritro Oral Suspension 25 mg/5 ml is also contraindicated in those patients with known hypersensitivity to Uritro Oral Suspension 25 mg/5 ml
Acute Overdose
Occasional incidents of acute overdosage of Uritro Oral Suspension 25 mg/5 ml have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended
Storage Condition
Store at 15-30° C
Innovators Monograph
You find simplified version here Uritro Oral Suspension 25 mg/5 ml
Uritro Oral Suspension 25 mg/5 ml contains Nitrofurantoin see full prescribing information from innovator Uritro Oral Suspension 25 mg/5 ml Monograph, Uritro Oral Suspension 25 mg/5 ml MSDS, Uritro Oral Suspension 25 mg/5 ml FDA label
FAQ
What is Uritro Oral Suspension 25 mg/5 ml used for?
Uritro Oral Suspension 25 mg/5 ml is an antibacterial medication used to treat bladder infections, but is not as effective for kidney infections. Uritro Oral Suspension 25 mg/5 ml is used to treat urinary tract infections.
How safe is Uritro Oral Suspension 25 mg/5 ml?
Uritro Oral Suspension 25 mg/5 ml is not suitable for everyone. To make sure it's safe for you, tell your doctor if you have: ever had an allergic reaction to nitrofurantoin or any other medicines in the past. Uritro Oral Suspension 25 mg/5 ml is effective in the prevention of UTI. Its use may be associated with increased non-severe adverse effects; severe adverse effects occur infrequently. The risk of severe toxicity seems to increase with the duration of Uritro Oral Suspension 25 mg/5 ml prophylaxis.
How does Uritro Oral Suspension 25 mg/5 ml work?
Uritro Oral Suspension 25 mg/5 ml works by killing bacteria or preventing their growth. Uritro Oral Suspension 25 mg/5 ml kills the bacteria by entering their cells and damaging their genetic material.
What are the common side effects of Uritro Oral Suspension 25 mg/5 ml?
Common side effects of Uritro Oral Suspension 25 mg/5 ml are include:
- feeling sick (nausea)
- being sick (vomiting) and diarrhoea.
- loss of appetite.
- headaches.
- dizziness or feeling sleepy.
Is Uritro Oral Suspension 25 mg/5 ml safe during pregnancy?
It's usually safe to take Uritro Oral Suspension 25 mg/5 ml during pregnancy . It's very unlikely that Uritro Oral Suspension 25 mg/5 ml is harmful during pregnancy. It goes straight into your pee, so very little of the medicine passes through to the unborn baby.
Is Uritro Oral Suspension 25 mg/5 ml safe during breastfeeding?
The use of Uritro Oral Suspension 25 mg/5 ml in breastfeeding mothers is generally safe, as only small amounts transfer into the breast milk.
Can I drink alcohol with Uritro Oral Suspension 25 mg/5 ml?
Yes, you can drink alcohol with Uritro Oral Suspension 25 mg/5 ml.
Can I drive after taking Uritro Oral Suspension 25 mg/5 ml?
Uritro Oral Suspension 25 mg/5 ml may cause you to become drowsy, so you should avoid driving when you are taking it. You should also stay away from operating heavy machinery.
When should be taken of Uritro Oral Suspension 25 mg/5 ml?
Uritro Oral Suspension 25 mg/5 ml take usually be first thing in the morning, at about midday, late in the afternoon, and at bedtime.
How many time can I take Uritro Oral Suspension 25 mg/5 ml daily?
Uritro Oral Suspension 25 mg/5 ml taken twice a day or 50mg taken 4 times a day.
How much Uritro Oral Suspension 25 mg/5 ml can I take daily?
The usual dose of Uritro Oral Suspension 25 mg/5 ml to: treat a urinary tract infection is either 100mg taken twice a day or 50mg taken 4 times a day. Severe infections may need a higher dose of 100mg taken 4 times a day.
How long does Uritro Oral Suspension 25 mg/5 ml take to work?
Uritro Oral Suspension 25 mg/5 ml should start working within three to five days, although it may take up to a week for symptoms to clear. Be sure to complete the full course of medication.
How long does Uritro Oral Suspension 25 mg/5 ml stay in my system?
Maximum urinary excretion usually occurs 4-5 hours after administration of macrocrystalline Uritro Oral Suspension 25 mg/5 ml. Uritro Oral Suspension 25 mg/5 ml has an elimination half-life of about 30 minutes or less.
Can I take Uritro Oral Suspension 25 mg/5 ml for a long time?
The Uritro Oral Suspension 25 mg/5 ml works as well as other long-term antibiotics for preventing recurrent urinary tract infections in women. However gastrointestinal side effects were more common in people on Uritro Oral Suspension 25 mg/5 ml.
Who should not take Uritro Oral Suspension 25 mg/5 ml?
You should not take Uritro Oral Suspension 25 mg/5 ml if you have severe kidney disease, urination problems, or a history of jaundice or liver problems caused by Uritro Oral Suspension 25 mg/5 ml You also should not take Uritro Oral Suspension 25 mg/5 ml if you are allergic to it, or if you have, severe kidney disease; a history of jaundice or liver problems caused by taking nitrofurantoin; if you are urinating less than usual or not at all; or if you are in the last 2 to 4 weeks of pregnancy.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happen If I stop taking Uritro Oral Suspension 25 mg/5 ml?
If you stop taking the Uritro Oral Suspension 25 mg/5 ml suddenly or don't take it at all: Your urinary tract infection may not go away and may get worse. If you stop taking this Uritro Oral Suspension 25 mg/5 ml suddenly, the bacteria that caused your urinary tract infection could become resistant to this drug. That means it won't work for you anymore.
What happen If I suddenly stop taking Uritro Oral Suspension 25 mg/5 ml?
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include: nausea. vomiting.
Can Uritro Oral Suspension 25 mg/5 ml affects my heart ?
Elderly patients are more likely to have age-related heart, which may require caution in patients receiving Uritro Oral Suspension 25 mg/5 ml.
Can Uritro Oral Suspension 25 mg/5 ml affect my kidneys?
Uritro Oral Suspension 25 mg/5 ml is a well-known cause of acute renal impairment from acute interstitial nephritis
Can Uritro Oral Suspension 25 mg/5 ml affects my liver?
Uritro Oral Suspension 25 mg/5 ml is currently one of the most common causes of drug induced liver injury. Liver injury from Uritro Oral Suspension 25 mg/5 ml can cause either an acute or chronic hepatitis-like syndrome.
What happens if I take Uritro Oral Suspension 25 mg/5 ml on an empty stomach?
If taken on an empty stomach, it may cause stomach upset.
