Urodilatin Ularitide

Urodilatin Ularitide Uses, Dosage, Side Effects, Food Interaction and all others data.

Urodilatin Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the systemic blood circulation. When injected into the blood, ularitide appears to cause diuresis (urine output) and natriuresis (sodium excretion), as well as vasodilation.Urodilatin Ularitide is currently in Phase 2 development as a potential treatment for patients with acute decompensated heart failure (ADHF).

Trade Name Urodilatin Ularitide
Generic Ularitide
Ularitide Other Names Ularitide, Urodilatin ularitide
Type
Formula C145H234N52O44S3
Weight Average: 3505.926
Monoisotopic: 3503.683361186
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Urodilatin Ularitide
Urodilatin Ularitide

Uses

Investigated for use/treatment in congestive heart failure.

How Urodilatin Ularitide works

Urodilatin Ularitide, a synthetic form of urodilatin, belongs to the family of natriuretic peptides. Urodilatin stimulates the intracellular guanylyl cyclase as the intracellular domain of the natriuretic peptide receptor A (NPR-A), the enzyme that catalyzes the conversion of GTP to cGMP [7]. Activation of cGMP-dependent protein kinase inhibits sodium reabsorption via an amiloride-sensitive channel and furthermore results in smooth muscle relaxation via a decrease in intracellular Ca2+ concentration. Thus, ularitide is an intrarenal paracrine regulator of sodium and water homeostasis.

Innovators Monograph

You find simplified version here Urodilatin Ularitide

*** Taking medicines without doctor's advice can cause long-term problems.
Share