Uv Doux Sunscreen
Uv Doux Sunscreen Uses, Dosage, Side Effects, Food Interaction and all others data.
Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays. Compared to older broad-spectrum chemical agents, bemotrizinol is more more fat soluble (oil soluble in cosmetic oils) to aid in efficacy and broad-spectrum activity . It is claimed to be photostable, which increases its onset of action and its efficiency in providing protection against UV-rays upon topical application . Bemotrizinol is commonly marketed as Tinosorb S and Escalol S.
Findings from an immature rat uterotrophic competitive binding assay suggest that bemotrizinol does not display significant binding affinities towards estrogen and androgen receptors in vitro, thus lacking intrinsic estrogenic, antiestrogenic, androgenic and antiandrogenic activity . Bemotrizinol minimizes erythema and provides excellent anti-aging effects as well as protectant effects on the skin's antioxidant defense system . In a comparative study of individuals with a history of polymorphic light eruption (PLE) undergoing photoprovocation, treatment of bemotrinizol was effective in preventing the development of PLE .
Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium. It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.
Zinc oxide is used to treat or prevent minor skin irritations such as burns, cuts, poison ivy, poison oak, poison sumac, and diaper rash. It is also used as a sunscreen.
Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.
| Trade Name | Uv Doux Sunscreen |
| Generic | Bemotrizinol + Titanium Dioxide + Zinc Oxide |
| Type | Gel |
| Therapeutic Class | |
| Manufacturer | Brinton Pharmaceuticals Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Bemotrizinol is an ingredient used in sunscreen to block UVA and UVB radiation.
Indicated as an active sunscreen agent.
Titanium dioxide is a sunscreen agent found in sunscreens that absorbs UV rays.
Titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide.
Zinc Oxide helps to To treat or prevent skin irritations (e.g., burns, bed sore, cuts, poison ivy, diaper rash). Protects chafed skin due to diaper rash and helps seal out wetness.
Uv Doux Sunscreen is also used to associated treatment for these conditions: SunburnBlisters, Dermatitis, Eczematous, Sunburn, Wounds, Abrasions, Dry, cracked skin, UV protection therapyAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation
How Uv Doux Sunscreen works
By absorbing UV-A and UVB rays ranging from 280 to 400nm, bemotrizinol serves to prevent the formation of free radicals induced by UV radiation .
Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.
It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.
Dosage
Uv Doux Sunscreen dosage
Apply thin layer topically every 8 hourly. Change wet and soiled diapers, promptly cleans the diaper area, allow to dry and apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or any time when exposure to wet diapers may be prolonged.
Side Effects
Usually well tolerated. Extremely low frequency of hypersensitivity reaction.
Toxicity
Oral LD50 in rat is > 2000 mg/kg and dermal LD50 in rabbit is > 2000 mg/kg, respectively .
Rat - LD50 Intratracheal (>100ug/kg ) Effects: Structural or functional changes in bronchi and trachea. There is inadequate evidence in humans for the carcinogenicity of titanium dioxide. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of titanium dioxide. Overall evaluation: Titanium dioxide is possibly carcinogenic to humans (Group 2B).
Acute oral toxicity (LD50): 7950 mg/kg [Mouse].
Precaution
For external use only. Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away
Volume of Distribution
No pharmacokinetic data available.
Six hours after titanium dioxide was administered to rats through IV injection at 250 mg/kg body weight, the highest concentration appeared in the liver; after 24 hours, the highest concentration was detected in the celiac lymph nodes, which filter the lymph from the liver.
Intended for local use only, no systemic absorption.
Elimination Route
No pharmacokinetic data available.
When male and female rats were fed a diet containing titanium dioxide (100 g/kg) for a period of about 32 days, a significant retention of titanium of 0.06 and 0.11 mg/kg wet weight was found only in the muscles; no retention was observed in the liver, spleen, kidney, bone, plasma, or erythrocytes
No significant percutaneous absorption from topically applied zinc oxide.
Half Life
No pharmacokinetic data available.
The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days...The retention half-time was 14 days for the first clearance phase and 88 days thereafter.
Intended for local use only, no systemic absorption.
Clearance
No pharmacokinetic data available.
The clearance of titanium dioxide from the lungs was studied in rats after inhalation of 15 or 100 mg/cu m. The average median aerodynamic diameter of the titanium dioxide particles was 1.48 um. After a single exposure, about 40-45% of the deposited particles were cleared from the lung in 25 days. At 15 mg/cu m, 0.7% was found in the hilar lymph nodes indicating penetration of titanium dioxide particles from alveoli into the lymphatic system and partial clearance by the lymphatic route. The clearance rate was similar after intra-tracheal administration of titanium dioxide. At an exposure of 100 mg/cu m, the clearance rate decreased drastically. /Other researchers/ demonstrated the presence of titanium dioxide in the lymphatic systems of 3 workers employed in processing titanium dioxide pigments.
Intended for local use only, no systemic absorption.
Elimination Route
No pharmacokinetic data available.
The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days.The retention half-time was 14 days for the first clearance phase and 88 days thereafter.
Intended for local use only, no systemic absorption.
Pregnancy & Breastfeeding use
This medication should be used with precautions only if clearly needed during pregnancy or while breast feeding
Contraindication
Known hypersensitivity to any component of the preparation
Acute Overdose
No overdose related problem is yet reported.
Storage Condition
keep in a cool and dry place, away from light.
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