Uzide
Uzide Uses, Dosage, Side Effects, Food Interaction and all others data.
Uzide stimulates the release of insulin from pancreatic beta-cells by facilitating Ca++ transport across the beta-cell membranes. It lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Extrapancreatic effects also may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Two extrapancreatic effects shown to be important in the action of Uzide are an increase in insulin sensitivity and a decrease in hepatic glucose production. The anti-oxidant, platelet inhibiting and fibrinolytic actions of Uzide involve processes which have been implicated in the pathogenesis of vascular complications of type 2 diabetes.
Based on the pharmacological properties, gliclazide is a second generation sulphonylurea which acts as a hypoglycemic agent. It stimulates β cells of the islet of Langerhans in the pancreas to release insulin. It also enhances peripheral insulin sensitivity. Overall, it potentiates insulin release and improves insulin dynamics.
| Trade Name | Uzide |
| Generic | Gliclazide |
| Gliclazide Other Names | Gliclazida, Gliclazide, Gliclazidum |
| Weight | 80mg |
| Type | Tablet |
| Formula | C15H21N3O3S |
| Weight | Average: 323.41 Monoisotopic: 323.130362722 |
| Protein binding | 94%, highly bound to plasma proteins |
| Groups | Approved |
| Therapeutic Class | Sulfonylureas |
| Manufacturer | Union Pharmaceuticals Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Uzide is used for control of blood glucose in patients with non-insulin dependent diabetes mellitus (Type-II, maturity onset diabetes mellitus) whose hyperglycemia cannot be controlled by diet alone.
Uzide is also used to associated treatment for these conditions: Type 2 Diabetes Mellitus
How Uzide works
Uzide binds to the β cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.
Dosage
Uzide dosage
Adult: The usual initial dose of Uzideis 40 to 80 mg daily, gradually increased, if necessary up to 320 mg daily until adequate control is achieved. A single dose should not exceed 160 mg. When higher doses are required it should be taken twice daily, according to the main meals of the day. For extended release tablet the initial recommended dose is 30 mg daily, even in elderly patients (>65 years); the daily dose may vary from 30 to 120 mg taken orally, once daily.
Uzide extend release tablet should be taken with food because there is increased risk of hypoglycemia if a meal is taken late. It is recommended that the medication be taken at breakfast time. If a dose is forgotten, the dose taken on the next day should not be increased. Dose titration should be carried out in steps of 30 mg, according to the fasting blood glucose response. Each step should last for at least two weeks. Uzide extend release tabletshould be neither broken nor chewed. Uzide extend release tablet30 mg, can replace Uzide 80 mg tabletsfor doses of 1 to 4 tablets per day.
Elderly: Plasma clearance of Uzide is not altered in the elderly and steady state plasma levels are similar to those in adults under 65 years. Clinical experience in the elderly shows that it is effective and well tolerated.
Children: Uzide as with other sulfonylureas is not indicated for the treatment of juvenile onset diabetes mellitus.
Side Effects
Hypoglycemia may occur in concurrent conditions such as hepatic & renal diseases, alcohol intoxication and adrenal and pituitary insufficiency. Mild gastro-intestinal disturbances including nausea, dyspepsia, diarrhea, and constipation have been reported but these types of adverse reactions can be avoided if Uzide is taken during a meal. Allergic dermatological reactions including rash, prurits, erythema, bullous eruption have been reported during treatment with the drug but are not known to be directly attributable to it. More serious reactions like leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, hemolytic anemia, cholestatic jaundice, GI hemorrhage have not been reported with Uzide.
Toxicity
LD50=3000 mg/kg (orally in mice). Uzide and its metabolites may accumulate in those with severe hepatic and/or renal dysfunction. Symptoms of hypoglycemia include: dizziness, lack of energy, drowsiness, headache and sweating.
Precaution
Uzide should be used carefully in patients with hepatic impairment. If there is definite hepatic disease then gliclazide should not be used. Consucon (Uzide) can be used safely in patients with renal insufficiency as it is extensively metabolized. Consucon has less sudden hypoglycaemic episode than other sulfonylurea group of drugs.
Interaction
The hypoglycemic effect of Uzide may be potentiated by NSAID (in particular aspirin), phenylbutazone, sulfonamides, coumarin derivatives, MAOIs, beta-adrenergic blockers, tetracyclines, chloramphenicol, clofibrate, cimetidine and miconazole tablets. Ingestion of alcohol may also increase the hypoglycemic effect of Uzide. Some drugs may on the contrary, reduce its activity e.g. barbiturates, corticosteroides, thiazide diuretics, thyroid hormones, laxatives and oral contraceptives.
Food Interaction
- Avoid alcohol.
- Take with or without food. Consistent food intake reduces the risk of hypoglycemia.
Elimination Route
Rapidly and well absorbed but may have wide inter- and intra-individual variability. Peak plasma concentrations occur within 4-6 hours of oral administration.
Half Life
10.4 hours. Duration of action is 10-24 hours.
Elimination Route
Metabolites and conjugates are eliminated primarily by the kidneys (60-70%) and also in the feces (10-20%).
Pregnancy & Breastfeeding use
Pregnant Women: Uzide should not be used in pregnant women although animal studies of Uzide have not shown any teratogenic effect.
Nursing Mothers: This drug is contraindicated when breast feeding.
Contraindication
Hypersensitivity to sulfonylurea, diabetes complicated by ketoacidosis with coma, as a sole therapy of insulin-dependent (Type-1) diabetes mellitus, diabetes when complicated by pregnancy & breast-feeding.
Special Warning
Elderly: Plasma clearance of Uzide is not altered in the elderly and steady state plasma levels are similar to those in adults under 65 years. Clinical experience in the elderly shows that it is effective and well tolerated.
Children: Uzide as with other sulfonylureas is not indicated for the treatment of juvenile onset diabetes mellitus.
Acute Overdose
Symptoms: Hypoglycaemia with or without coma, convulsions or other neurological disorders.
Management: Carbohydrate intake, dosage adjustment and/or change of diet may be helpful. Admin rapid IV inj of concentrated glucose soln for hypoglycaemic coma.
Storage Condition
Store in a cool and dry place, below 30° C and away from light.
Innovators Monograph
You find simplified version here Uzide
Uzide contains Gliclazide see full prescribing information from innovator Uzide Monograph, Uzide MSDS, Uzide FDA label
FAQ
What is Uzide used for?
Uzide is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough.
How safe is Uzide?
Uzide is safe to take for a long time. There's no evidence it harms your pancreas or your general health. But Uzide may stop working properly after a while. Your doctor may then want to stop it or add a different medicine to help keep your blood sugar level stable.
How does Uzide work?
Uzide works by increasing the amount of insulin your body makes.
What are the common side effects of Uzide?
Common side effects of Uzide are include:
- stomach ache or indigestion.
- feeling sick (nausea)
- being sick (vomiting) or diarrhoea.
- constipation.
Is Uzide safe during pregnancy?
Uzide is not generally recommended in pregnancy and while breastfeeding. It's not clear whether Uzide harms an unborn baby. For safety, your doctor will probably change your medicine to insulin before you become pregnant or as soon as you find out you're pregnant.
Is Uzide safe during breastfeeding?
Uzide is not generally recommended in pregnancy and while breastfeeding.
Can I drink alcohol with Uzide?
Yes, you can drink alcohol while taking Uzide, but it's best for men and women to drink no more than 2 units a day. Drinking more than this can increase the risk of low blood sugar.
Can I drive after taking Uzide?
If your blood sugar levels are stable, your ability to drive, cycle or use machines or tools should not be affected by Uzide. But if your blood sugar levels become too low, this can reduce your concentration. If this happens to you, do not drive, cycle or use machines or tools until you feel better.
When should be taken of Uzide?
If you take Uzide once a day, it's best to take it in the morning with breakfast. Uzide can sometimes make your blood sugar level too low . Carry some sweets or fruit juice with you to help when this happens.
Can I take Uzide on an empty stomach?
Uzide tablets should be taken before food , either with breakfast or the first main meal of the day.
How long does Uzide take to work?
When taken 30 minutes before breakfast, Uzide produced a peak of IRI 30 minutes after the meal; taken immediately before or after, it took twice to three times as long to produce an IRI peak.
How long does Uzide last in the body?
Uzide is more effective when administered about 30 minutes before a meal. Blood sugar control persists for up to 24 hours following a single dose, even though levels of Uzide in the blood are barely detectable.
How often can I take Uzide?
For standard-release Uzide, the maximum daily dose is 320mg. If you need to take more than 160mg a day, take the tablets twice a day with your morning and evening meals.
Who should not take Uzide?
Uzide is only for adults. Do not give this medicine to children under 18 years.
What happen If I missed Uzide?
If you missed a dose of Uzide, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses together to make up for a missed dose.
What happen if I overdose of Uzide?
Never take more than the prescribed dose of Uzide. If you suspect that you might have taken an overdose of this medicine, go to the nearest emergency medical department/hospital.
Can Uzide affects my heart ?
If you have problems with the heart and blood vessels, use Uzide with caution as it can increase the risk of heart failure.
Will Uzide affect my fertility?
There's no firm evidence to suggest that taking Uzide will reduce fertility in either men or women.
Does Uzide affect kidney function?
Uzide can be considered in renal impairment if appropriate attention is paid to the dose.
Can Uzide cause liver damage?
This case strongly suggests that Uzide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis. In patients who show abnormal liver function tests, the immediate discontinuation of Uzide is recommended.
