Vah Md

Vah Md Uses, Dosage, Side Effects, Food Interaction and all others data.

Vah Md was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.

Vah Md, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Vah Md is used for its anti-inflammatory, analgesic, and antipyretic activities in the management of osteoarthritis (OA) and for the treatment of dysmenorrhea or acute pain. Unlike celecoxib, valdecoxib lacks a sulfonamide chain and does not require CYP450 enzymes for metabolism.

Trade Name Vah Md
Availability Discontinued
Generic Valdecoxib
Valdecoxib Other Names Valdecoxib
Related Drugs Humira, Buprenex, aspirin, prednisone, ibuprofen, acetaminophen, tramadol, meloxicam, naproxen, diclofenac
Weight 20mg
Type Tablet
Formula C16H14N2O3S
Weight Average: 314.359
Monoisotopic: 314.072513014
Protein binding

98%

Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer Abbott Healthcare Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Vah Md
Vah Md

Uses

Vah Md is a COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea.

For the treatment of osteoarthritis and dysmenorrhoea

Vah Md is also used to associated treatment for these conditions: Osteoarthritis (OA), Primary Dysmenorrhoea, Rheumatoid Arthritis

How Vah Md works

Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. Vah Md selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, important for the mediation of inflammation and pain. Unlike non-selective NSAIDs, valdecoxib does not inhibit platelet aggregation.

Toxicity

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare.

Food Interaction

  • Avoid alcohol. Ingesting alcohol may increase the risk of gastrointestinal bleeding.
  • Take with or without food.

Volume of Distribution

  • 86 L

Elimination Route

Oral bioavailability is 83%.

Half Life

8-11 hours

Clearance

  • oral cl=6 L/h
  • 6 – 7 L/h [In patients undergoing hemodialysis]
  • 6 – 7 L/h [healthy elderly subjects]

Elimination Route

Vah Md is eliminated predominantly via hepatic metabolism with less than 5% of the dose excreted unchanged in the urine and feces. About 70% of the dose is excreted in the urine as metabolites, and about 20% as valdecoxib N-glucuronide.

Innovators Monograph

You find simplified version here Vah Md

*** Taking medicines without doctor's advice can cause long-term problems.
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