Valamin

Valamin Uses, Dosage, Side Effects, Food Interaction and all others data.

1000 ml contains: L-Isoleucine: 10.40 gm L-Leucine: 13.09 gm L-Lysine monoacetate: 9.71 gm L-Lysine 6.88 gm L-Methionine 1.1 gm Acetylcysteine 0.70 gm L-Cysteine 0.52 gm L-Phenylalanine 0.88 gm L-Threonine 4.40 gm L-Tryptophan 0.70 gm L-Valine 10.08 gm Arginine 10.72 gm L-Histidine 2.80 gm Aminoacetic acid 5.82 gm L-Alanine 4.64 gm L-Proline 5.73 gm L-Serine 2.24 gm Glacial acetic acid 4.42 gm Water for Injections q.s.

Glycine irrigation solution contains glycine which is an amino acid and a non-electrolyte. It is therefore non-conductive and suitable for irrigation purpose. Glycine Irrigation Solution minimizes the risk of intravascular haemolysis which can occur from absorption of plain water. Glycine Irrigation Solution is rapidly degraded in the liver by glycine oxidase.

Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.

Valamin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Valamin
Generic	Amino acid + D-sorbitol + L-arginine HCl + L-histidine HCl monohydrate + L-isoleucine + L-leucine + L-lysine HCl + L-methionine + L-phenylalanine + L-valine + Glycine + Osmolarity: + Energy:
Type	Injection
Therapeutic Class
Manufacturer	Sanbe Farma
Available Country	Indonesia,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Parenteral amino acid supply in severe forms of hepatic failure (liver insufficiency) with and without encephalopathy. For supply of amino acids as part of a parenteral nutrition regimen when oral or enteral nutrition is impossible or insufficient or contraindicated.

This is used for irrigating fluid of choice in:

Transurethral resection of prostate.
Endoscopic procedures within the urinary tract.
Urinary bladder surgery etc.

Valamin is also used to associated treatment for these conditions: Coronary vascular graft occlusion, Deep Vein Thrombosis, Myocardial Infarction, Stroke, Transient Ischemic Attack, Vascular Occlusion, Bladder distension, Bladder irrigation therapy, Irrigation therapy, Recovery, Amino acid supplementation

How Valamin works

In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.

Dosage

Valamin dosage

For intravenous infusion. Usual dose: 1.0 to 1.25 ml/kg/hour. Max. dosage: 1.5 g amino acids/kg/day = 1300 ml/day at 70 kg body weight. Constant checking of serum electrolytes, fluid balance and acid-base balance is mandatory. Amino Acid 8% is used as long as required by therapy.

The total volume of solution used for irrigation depends on the judgment of the attending surgeon. Height from the operating table of 60 cm (approx. 2ft) is likely to cause increased intravascular absorption of glycine.

Check infusion set and infusion solution prior to use
Pull moderately to tear off the protective cover of the Eurohead
Hold lightly the Eurohead but not the bag
Open the flow regulator fully and hold the giving set on the top white area, but not the membrane venting region
Insert the spike of the administration set to the Eurohead and fit the connector of the administration set firmly to the needle
Gradually allow the fluid to flow down to the needle tip and close
Remove the protective cover of the needle
Locate the veinpuncture site and clean the site with an antiseptic solution, and then insert the needle
Securely tape the puncture site
Securely tape the wings and tubing
Start infusion while adjusting drip speed

Side Effects

Due to the special composition of this preparation, use in indications other than those recommended may result in amino acid imbalances and severe metabolic disorders.

Large intravenous doses of glycine are known to cause nausea and salivation. Other consequences of systemic absorption of glycine include electrolyte loss, diuresis, edaema, thirst, dehydration, cardiovascular and pulmonary disorders.

Toxicity

ORL-RAT LD₅₀ 7930 mg/kg, SCU-RAT LD₅₀ 5200 mg/kg, IVN-RAT LD₅₀ 2600 mg/kg, ORL-MUS LD₅₀ 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.

Precaution

Precautions: Patients with cardiovascular disease should be evaluated after transurethral resection of prostate using glycine. Care should be exercised if the liver or kidney is impaired.

Warning: Aseptic technique is essential while using glycine. Unused portion should be discarded. Do not use if the bottle is leaking, solution is cloudy, contains particles or after expiry date.

Interaction

Because of the increased risk of microbiological contamination and incompatibilities, amino acid solutions should not be mixed with other drugs. Should it become necessary to add other nutrients like carbohydrates, lipid emulsions, electrolytes, vitamins or trace elements to Amino Acid 8% for complete nutrition, care should be given to hygienic admixing, good blending and, in particular, to compatibility.

Additives may be incompatible. When introducing additives, use aseptic technique, mix thoroughly and do not store.

Elimination Route

Absorbed from the small intestine via an active transport mechanism.

Contraindication

Disturbance of amino acid metabolism, metabolic acidosis, fluid overload, hyponatremia, hypokalemia, renal insufficiency, decompensated cardiac insufficiency, shock, hypoxia. No specific studies have been performed to assess the safety of Amino Acid 8% in pregnancy and lactation.

Glycine Irrigation Solution is not for injection in any route. It is contraindicated in patients with anuria.

Storage Condition

Amino Acid 8% should not be stored after the addition of other components. Do not store above 25°C. Do not freeze. Shelf Life: 36 months. Do not use Amino Acid after the expiry date. Do not use if the solution is cloudy or if the container is damaged. Keep out of the reach of children.

Store at controlled room temperature, protect from light and heat