Varucefa

Varucefa Uses, Dosage, Side Effects, Food Interaction and all others data.

A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Varucefa is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Varucefa
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Varucefa
Availability	Discontinued
Generic	Ceftizoxime
Ceftizoxime Other Names	Ceftizoxima, Ceftizoxime, Ceftizoximum
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Type
Formula	C₁₃H₁₃N₅O₅S₂
Weight	Average: 383.403 Monoisotopic: 383.035809931
Protein binding	30% protein-bound across the standard concentration range.
Groups	Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country	South Korea, Vietnam
Last Updated:	September 19, 2023 at 7:00 am

Uses

Varucefa is a third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea.

Cetizoxime was previously indicated for the treatment of infections due to susceptible strains of bacteria.

Varucefa is also used to associated treatment for these conditions: Bacterial Infections

How Varucefa works

Varucefa is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Varucefa, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that ceftizoxime interferes with an autolysin inhibitor.

Food Interaction

No interactions found.

Varucefa Hypertension interaction

[Moderate] Parenteral ceftizoxime sodium contains approximately 60 mg (2.6 mEq) of sodium per each gram of ceftizoxime activity.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.