Vegacal Plus
Vegacal Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone
Zinc is an essential trace mineral, which means that it must be obtained from the diet since the body cannot make enough. Next to iron, zinc is the most abundant trace mineral in the body. Stored primarily in muscle, zinc is also found in high concentrations in red and white blood cells, the retina of the eye, bones, skin, kidneys, liver, and pancreas. Some of the symptoms of zinc deficiency include loss of appetite, poor growth, weight loss, impaired taste or smell, poor wound healing, skin abnormalities (such as acne, atopic dermatitis and psoriasis), hair loss, night blindness, hypogonadism and delayed sexual maturation, white spots on the fingernails and feelings of depression.
Trade Name | Vegacal Plus |
Generic | Calcium Citrate + Magnesium Hydroxide / Milk Of Magnesia + Zinc Sulphate Monohydrate + Vitamin D3 / Cholecalciferol |
Weight | 1000mg |
Type | Tablet |
Therapeutic Class | |
Manufacturer | Olamic Healthcare |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Calcium citrate is an ingredient found in a variety of supplements and vitamins.
For use as an over the counter calcium supplement.
Zinc Sulphate is used for Recurrent Respiratory Tract Infections; Diarrhoea; Loss of appetite; Severe growth retardation; Deformed bone formation; Impaired immunological response; Acrodermatitis enteropathica; Parakeratatic skin lesions; Defective and delayed wound healing; Anaemia; Night blindness; Mental disturbances
Vegacal Plus is also used to associated treatment for these conditions: Calcium Deficiency, Deficiency of Vitamin D3, Deficiency, Vitamin D, Folate deficiency, Hypocalcemia, Iron Deficiency (ID), Osteoporosis
How Vegacal Plus works
Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
Dosage
Vegacal Plus dosage
Syrup-
- Children under 10 kg: One teaspoonful 2 times daily.
- Children within 10 to 30 kg: Two teaspoonful 1-3 times daily.
- Adults and children over 30 kg body weight: Four teaspoonful 1-3 times daily.
Tablet-In the treatment of Diarrhoea Zinc should be given as soon as diarrhoea starts:
- For infants between 2 to 6 months of age: 10 mg Zinc once daily for 10-14 days.
- For children between 6 months to 5 years of age: 20 mg Zinc once daily for 10-14 days.
For other indications:
- The recommended dose for children: 2 to 2.5 mg/kg/day.
- Children under 10 kg: 10 mg Zinc 2 times daily.
- Children within 10 to 30 kg: 20 mg Zinc 1-3 times daily.
- Adults and children over 30 kg body weight: 40 mg Zinc 1-3 times daily.
Dispersible Tablet-
- Place the tablet in a teaspoon
- Add adequate amount of water
- Let the tablet dissolve completely
- Give the entire spoonful solution
Side Effects
In case of zinc mild side effects such as gastric ulcer, nausea, vomiting, metallic taste, headache, drowsiness have been observed.
Toxicity
Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis . Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence .
Precaution
Concurrent administration of Zinc salt with penicillamine might diminish the effect of Penicillamine. The absorption of Zinc, although poor, may be decreased by various compounds including some foods. Chelation may occur with tetracyclines.
Interaction
Zinc may inhibit the absorption of concurrently administered tetracyclines, when both are being given an interval of at least 3 hours.
Elimination Route
The percentage of calcium absorbed varies inversely with intake . Tmax of about 3.5-5h varying with formulation .
Elimination Route
Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions .
Pregnancy & Breastfeeding use
Pregnant women and nursing mothers should avoid zinc doses higher than RDA amounts.
Contraindication
It is contraindicated in patients with hypersensitivity to Zinc.
Acute Overdose
Zinc sulphate is corrosive in overdose. Symptoms are corrosion and inflammation of the mucous membrane of the mouth and stomach; ulceration of the stomach followed by perforation may occur. Gastric lavage and emesis should be avoided. Demulcents such as milk should be given. Chelating agents such as sodium edetate may be useful.
Storage Condition
Store in a cool place. The syrup should be protected from light.
Innovators Monograph
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