Venlafaxin Pfizer ER
Venlafaxin Pfizer ER Uses, Dosage, Side Effects, Food Interaction and all others data.
Venlafaxin Pfizer ER is the principal active metabolite of venlafaxine. The exact mechanism is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the CNS, through inhibition of their reuptake.
Venlafaxin Pfizer ER is a selective serotonin and norepinephrine reuptake inhibitor. It lacks significant activity on muscarinic-cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. Venlafaxin Pfizer ER does not appear to exert activity against calcium, chloride, potassium and sodium ion channels and also lacks monoamine oxidase (MAO) inhibitory activity. It was also shown to lack significant activity again the cardiac potassium channel, hERG, in vitro. Compared to other SNRIs, desvenlafaxine undergoes simple metabolism, has a low risk of drug-drug interactions and does not have to be extensively titrated to reach a therapeutic dose.
| Trade Name | Venlafaxin Pfizer ER |
| Availability | Prescription only |
| Generic | Desvenlafaxine |
| Desvenlafaxine Other Names | Desvenlafaxina, Desvenlafaxine |
| Related Drugs | Rexulti, sertraline, trazodone, Lexapro, Zoloft, citalopram, Cymbalta, Prozac |
| Type | |
| Formula | C16H25NO2 |
| Weight | Average: 263.3752 Monoisotopic: 263.188529049 |
| Protein binding | Protein binding is 30% and this is independent of drug concentration. |
| Groups | Approved, Investigational |
| Therapeutic Class | Serotonin-norepinephrine reuptake inhibitor (SNRI) |
| Manufacturer | |
| Available Country | Switzerland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Venlafaxin Pfizer ER, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used for the treatment of major depressive disorder (MDD). The efficacy of Venlafaxin Pfizer ER has been established in four short-term (8-week, placebo-controlled studies) and two maintenance studies in adult outpatients who met DSM-IV criteria for major depressive disorder.
Venlafaxin Pfizer ER is also used to associated treatment for these conditions: Hot Flushes, Major Depressive Disorder (MDD)
How Venlafaxin Pfizer ER works
Venlafaxin Pfizer ER, the active metabolite of venlafaxine, is a selective serotonin and norepinephrine reuptake inhibitor. Venlafaxin Pfizer ER inhibits neurotransmitter reuptake in serotonin, norepinephrine, and dopamine transporters. Venlafaxin Pfizer ER inhibits serotonin transporters with 10 times the affinity of norepinephrine transporters, and dopamine transporters with the lowest affinity. In vitro, desvenlafaxine has no inhibition of monoamine oxidase, and almost no affinity for muscarinic, cholinergic, H1-histaminergic, and alpha1-adrenergic receptors.
Dosage
Venlafaxin Pfizer ER dosage
The recommended dose for Venlafaxin Pfizer ERis 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. Venlafaxin Pfizer ER should be taken at approximately the same time each day. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.In clinical studies, doses of 10 mg to 400 mg per day were studied.
In clinical studies, doses of 50 mg to 400 mg per day were shown to be effective, although no additional benefit was demonstrated at doses greater than 50 mg per day and adverse reactions and discontinuations were more frequent at higher doses.
The 25 mg per day dose is intended for a gradual reduction in dose when discontinuing treatment. When discontinuing therapy, gradual dose reduction is recommended whenever possible to minimize discontinuation symptoms
Side Effects
Suicidal thinking/ behaviour, HTN, mydriasis, seizure, hyponatraemia, interstitial lung disease and eosinophilic pneumonia; nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, sexual function disorders in males (e.g. anorgasmia, decreased libido, abnormal orgasm, delayed ejaculation, erectile dysfunction, ejaculation disorder, ejaculation failure, sexual dysfunction).
Toxicity
Venlafaxin Pfizer ER is excreted in breast milk and as a result, nursing mothers must either stop the drug or stop breast feeding depending on the risks and benefit to mother and child.
Precaution
Patient with pre-existing HTN or other conditions that may be compromised by increased BP, raised intraocular pressure, personal or family history of mania or hypomania; CV, cerebrovascular or lipid metabolism disorders; seizure disorder. Avoid abrupt withdrawal. Renal and moderate to severe hepatic impairment. Pregnancy and lactation.
Interaction
Increased risk of bleeding with aspirin or other NSAIDs, warfarin and other anticoagulants.
Food Interaction
- Avoid alcohol.
- Avoid St. John's Wort.
- Take with or without food. The absorption is unaffected by food.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Venlafaxin Pfizer ER Hypertension interaction
[Moderate] Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure.
Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension.
Blood pressure should be assessed prior to initiating treatment and monitored regularly.
The dose should be reduced or discontinued if necessary.
Venlafaxin Pfizer ER Drug Interaction
Major: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, duloxetine, escitalopram, lithium, lisdexamfetamine, bupropion, sertralineModerate: aripiprazole, lamotrigine, lurasidone, pregabalin, quetiapine, alprazolam, cetirizineUnknown: omega-3 polyunsaturated fatty acids, metoprolol, cyanocobalamin, ascorbic acid, cholecalciferol
Venlafaxin Pfizer ER Disease Interaction
Major: depression, renal diseaseModerate: glaucoma, hypertension, hyponatremia, mania, seizures, urinary tract obstruction
Volume of Distribution
3.4L/kg.
Elimination Route
Oral bioavailability is approximately 80% and is unaffected by food. Peak plasma concentration is reached in 7.5 hours.
Half Life
The mean terminal half life is 11.1 hours and may be prolonged in patients with renal and/or moderate to severe hepatic impairment.
Elimination Route
Venlafaxin Pfizer ER is mainly excreted in the urine. 45% of the dose is unchanged in the urine, 19% is excreted as a glucuronide metabolite, and 4. No dosage adjustment is necessary for gender, ethnicity, food, or combination with other psychotropics.
Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Contraindication
Concurrent use or within 14 days of discontinuing MAOIs (e.g. linezolid, IV methylene blue). Initiation of MAOI at least 7 days after discontinuing desvenlafaxine.
Special Warning
Hepatic impairment (Moderate to severe): 50 mg daily. Max: 100 mg once daily.
Renal Impairment:
- CrCl <30 or ESRD: 25 mg daily or 50 mg every other day. Supplemental doses should not be given after dialysis.
- CrCl (30-50): Max 50 mg once daily.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Venlafaxin Pfizer ER
Venlafaxin Pfizer ER contains Desvenlafaxine see full prescribing information from innovator Venlafaxin Pfizer ER Monograph, Venlafaxin Pfizer ER MSDS, Venlafaxin Pfizer ER FDA label
FAQ
What is Venlafaxin Pfizer ER used for?
Venlafaxin Pfizer ER is used to treat depression. Venlafaxin Pfizer ER is in a class of medications called selective serotonin and Venlafaxin Pfizer ER is a medication used to treat depression. It is recommended that the need for further treatment be occasionally reassessed.
How safe is Venlafaxin Pfizer ER?
Safety results indicate that Venlafaxin Pfizer ER treatment is generally safe and well tolerated.
How does Venlafaxin Pfizer ER work?
Venlafaxin Pfizer ER works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.
What are the common side effects of Venlafaxin Pfizer ER?
Common side effects of Venlafaxin Pfizer ER are include:
Drowsiness, dizziness, nausea, dry mouth, constipation, loss of appetite, weight loss, blurred vision, nervousness, trouble sleeping, or excessive sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Is Venlafaxin Pfizer ER safe during pregnancy?
Venlafaxin Pfizer ER should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. A pregnancy exposure registry is available.
Is Venlafaxin Pfizer ER safe during breastfeeding?
Modest doses of Venlafaxin Pfizer ER are excreted into breastmilk, but serum drug levels of breastfed infants are less than 10% of simultaneous maternal levels. Total Venlafaxin Pfizer ER exposure of breastfed infants is about half of that experienced by breastfed infants whose mothers are taking Venlafaxin Pfizer ER.
Can I drink alcohol with Venlafaxin Pfizer ER?
You should avoid or limit the use of alcohol while being treated with Venlafaxin Pfizer ER.
Can I drive after taking Venlafaxin Pfizer ER ?
You should avoid driving a car or operating machinery.
When is the best time to take Venlafaxin Pfizer ER?
Venlafaxin Pfizer ER is usually taken once a day with or without food. Take Venlafaxin Pfizer ER at around the same time every day.
How long does Venlafaxin Pfizer ER take to work ?
Venlafaxin Pfizer ER may show some improvement within the first 1-2 weeks.
Can I take Venlafaxin Pfizer ER for a long time?
There are no known problems associated with long term use of Venlafaxin Pfizer ER. It is a safe and effective medication when used as directed.
How long can I take Venlafaxin Pfizer ER?
Clinical guidelines for depression treatment recommend that you keep taking your antidepressant for 4 to 9 months after your depression symptoms improve.
Who should not take Venlafaxin Pfizer ER?
You should not use Venlafaxin Pfizer ER if you are allergic to Venlafaxin Pfizer ER. Do not use Venlafaxin Pfizer ER within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Can I overdose on Venlafaxin Pfizer ER ?
Venlafaxin Pfizer ER can cause delayed onset seizures. There is also a risk of serotonin toxicity in overdose. There are active metabolites, so symptoms can be prolonged.
Does Venlafaxin Pfizer ER affect fertility?
While Venlafaxin Pfizer ER may or may not affect fertility for the woman, it is important to note that antidepressants typically reduce sex drive.
Does Venlafaxin Pfizer ER cause high blood pressure?
Venlafaxin Pfizer ER may increase blood pressure. Your blood pressure should be checked regularly while you are taking this medication.
Is Venlafaxin Pfizer ER good for anxiety?
Venlafaxin Pfizer ER is not FDA approved to treat anxiety.
Can Venlafaxin Pfizer ER affect my kidneys?
Any medication, if taken without consultation with your physician, can cause kidney damage.
